Porphyromonas gingivalis survival skills: Immune evasion

2021 ◽  
Author(s):  
Shaowen Zheng ◽  
Shiwen Yu ◽  
Xiaomiao Fan ◽  
Yonghuan Zhang ◽  
Yangyang Sun ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Immune Evasion ◽  
Survival Skills

scholarly journals Proteolysis of CD14 on Human Gingival Fibroblasts by Arginine-Specific Cysteine Proteinases from Porphyromonas gingivalis Leading to Down-Regulation of Lipopolysaccharide-Induced Interleukin-8 Production

2002 ◽  
Vol 70 (6) ◽  
pp. 3304-3307 ◽  
Author(s):  
Hiroyuki Tada ◽  
Shunji Sugawara ◽  
Eiji Nemoto ◽  
Nobuhiro Takahashi ◽  
Takahisa Imamura ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Porphyromonas Gingivalis ◽  
Immune Evasion ◽  
Interleukin 8 ◽  
Human Gingival Fibroblasts ◽  
Cysteine Proteinases ◽  
Gingival Fibroblasts ◽  
Down Regulation ◽  
Periodontal Tissues ◽  
Recognition Receptor

ABSTRACT Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.

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