Mangiferin amelioratesPorphyromonas gingivalis-induced experimental periodontitis by inhibiting phosphorylation of nuclear factor-κB and Janus kinase 1-signal transducer and activator of transcription signaling pathways

2016 ◽  
Vol 52 (1) ◽  
pp. 1-7 ◽  
Author(s):  
H. Li ◽  
Q. Wang ◽  
Y. Ding ◽  
C. Bao ◽  
W. Li
Keyword(s):  
Signaling Pathways ◽  
Nuclear Factor Κb ◽  
Janus Kinase ◽  
Nuclear Factor ◽  
Signal Transducer ◽  
Janus Kinase 1 ◽  
Experimental Periodontitis

scholarly journals Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma

Blood ◽  
2008 ◽  
Vol 111 (7) ◽  
pp. 3701-3713 ◽  
Author(s):  
Lloyd T. Lam ◽  
George Wright ◽  
R. Eric Davis ◽  
Georg Lenz ◽  
Pedro Farinha ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Gene Expression Signature ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Janus Kinase ◽  
Nuclear Factor ◽  
Signal Transducer ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract The activated B cell–like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL) is characterized by constitutive activation of the nuclear factor-κB (NF-κB) pathway. In this study, we showed that the NF-κB pathway induced the expression of the cytokines interleukin (IL)-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of total and phosphorylated signal transducer and activator of transcription (STAT) 3 protein, suggesting autocrine signaling. Using RNA interference for STAT3, we defined a gene expression signature of IL-6 and IL-10 signaling through STAT3. Based on this signature, we constructed a molecular predictor of STAT3 signaling that defined a subset of ABC DLBCL tumors with high expression of STAT3, IL-6, and/or IL-10 and their downstream targets. Although the STAT3-high and STAT3-low subsets had equivalent expression of genes that distinguish ABC DLBCL from germinal center B cell–like DLBCL, STAT3-high ABC DLBCLs had higher expression of signatures that reflected NF-κB activity, proliferation, and glycolysis. A small-molecule inhibitor of Janus kinase signaling, which blocked STAT3 signature expression, was toxic only for ABC DLBCL lines and synergized with an inhibitor of NF-κB signaling. These findings suggest that the biological interplay between the STAT3 and NF-κB pathways may be exploited for the treatments of a subset of ABC DLBCLs.

scholarly journals Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-κB and STAT3

Tumor Biology ◽  
2018 ◽  
Vol 40 (1) ◽  
pp. 101042831773136 ◽  
Author(s):  
Jing Ma ◽  
Wei Gong ◽  
Su Liu ◽  
Qian Li ◽  
Mengzheng Guo ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Tyrosine Kinase ◽  
Signaling Pathways ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Potential Treatment ◽  
Signal Transducer ◽  
Bruton's Tyrosine Kinase ◽  
Myeloma Cells ◽  
Transcription 3

The oncogenic microRNA-21 contributes to the pathogenesis of multiple myeloma. Ibrutinib (also referred to as PCI-32765), an inhibitor of Bruton’s tyrosine kinase, while its effects on multiple myeloma have not been well described. Here, we show that microRNA-21 is an oncogenic marker closely linked with progression of multiple myeloma. Moreover, ibrutinib attenuates microRNA-21 expression in multiple myeloma cells by inhibiting nuclear factor-κB and signal transducer and activator of transcription 3 signaling pathways. Taken together, our results suggest that ibrutinib is a promising potential treatment for multiple myeloma. Further investigation of mechanisms of ibrutinib function in multiple myeloma will be necessary to evaluate its use as a novel multiple myeloma treatment.

scholarly journals Reprogramming Tumor Associated Macrophage Phenotype by a Polysaccharide from Ilex asprella for Sarcoma Immunotherapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3816 ◽  
Author(s):  
Qiu Li ◽  
Zhihui Hao ◽  
Yeting Hong ◽  
Wei He ◽  
Wenwen Zhao
Keyword(s):  
Survival Rate ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Signal Transducer ◽  
Macrophage Phenotype ◽  
Therapeutic Tool ◽  
Acidic Polysaccharide ◽  
Tumor Associated Macrophage ◽  
Animal Survival ◽  
Anti Tumor Activity

We report here the discovery of an acidic polysaccharide, namely IAPS-2, from the root of Ilex asprella, with anti-tumor activity via a repolarizing tumor associated macrophages (TAMs) phenotype. We obtained IAPS-2 polysaccharide from this herb based on acidity and found that IAPS-2 expressed the activity of promoting the secretion of anti-tumor cytokines in macrophages. Furthermore, we evaluated its anti-tumor effect on TAM cells, through the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription (STAT) signaling. In particular, in the tumor murine model, IAPS-2 demonstrated that it could significantly inhibit the growth of tumors via modulating the function of TAMs and increase the animal survival rate. In summary, IAPS-2, with a clearly illustrated chemical composition, potent anti-tumor activity, and a solid mechanism of action, may be developed into a valuable therapeutic tool for cancer immunotherapy.

scholarly journals Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris

2019 ◽  
Vol Volume 12 ◽  
pp. 497-508
Author(s):  
Azza Gaber Antar Farag ◽  
Rehab Samaka ◽  
Eman Nabil Elshafey ◽  
Wafaa Ahmed Shehata ◽  
Eman Gamal El Sherbiny ◽  
...  
Keyword(s):  
Psoriasis Vulgaris ◽  
Immunohistochemical Study ◽  
Janus Kinase ◽  
Signal Transducer ◽  
Janus Kinase 1 ◽  
Transcription 3
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