Melatonin, given at the time of reperfusion, prevents ventricular arrhythmias in isolated hearts from fructose-fed rats and spontaneously hypertensive rats

2013 ◽  
Vol 55 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Emiliano Raúl Diez ◽  
Nicolás Federico Renna ◽  
Natalia Jorgelina Prado ◽  
Carina Lembo ◽  
Amira Zulma Ponce Zumino ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Isolated Hearts

Age-related increase in the incidence of ventricular arrhythmias in isolated hearts from spontaneously hypertensive rats

1989 ◽  
Vol 3 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Marco Pahor ◽  
Pietro Lo Giudice ◽  
Roberto Bernabei ◽  
Marco Di Gennaro ◽  
Licia Pacifici ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Isolated Hearts ◽  
Age Related ◽  
Related Increase

scholarly journals Cardiac Tolerance to Ischemia in Neonatal Spontaneously Hypertensive Rats

2012 ◽  
pp. S145-S153 ◽  
Author(s):  
Z. CHARVÁTOVÁ ◽  
I. OŠŤÁDALOVÁ ◽  
J. ZICHA ◽  
J. KUNEŠ ◽  
H. MAXOVÁ ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Global Ischemia ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Isolated Hearts ◽  
Baseline Values ◽  
The Difference ◽  
Wistar Kyoto

Hypertension is the risk factor of serious cardiovascular diseases, such as ischemic heart disease and atherosclerosis. The aim of the present study was to analyze the development of cardiac tolerance to ischemia in neonatal spontaneously hypertensive rats (SHR) and possible protective effect of ischemic preconditioning (IP) or adaptation to intermittent high-altitude hypoxia (IHAH). For this purpose we used 1- and 10-day-old pups of SHR and their normotensive control Wistar Kyoto rats (WKY). Isolated hearts were perfused in the Langendorff mode with Krebs-Henseleit solution at constant pressure, temperature and rate. Cardiac tolerance to ischemia was expressed as a percentage of baseline values of developed force (DF) after global ischemia. IP was induced by three 3-min periods of global ischemia, each separated by 5-min periods of reperfusion. IHAH was simulated in barochamber (8 h/day, 5000 m) from postnatal day 1 to 10. Cardiac tolerance to ischemia in 1-day-old SHR was higher than in WKY. In both strains tolerance decreased after birth, and the difference disappeared. The high cardiac resistance in 1- and 10-day-old SHR and WKY could not be further increased by both IP and adaptation to IHAH. It may be concluded that hearts from newborn SHR are more tolerant to ischemia/reperfusion injury as compared to age-matched WKY; cardiac resistance decreased in both strains during the first ten days, similarly as in Wistar rats.

scholarly journals Gsk-3βInhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Luisa F. González Arbeláez ◽  
Ignacio A. Pérez Núñez ◽  
Susana M. Mosca
Keyword(s):  
Lipid Peroxidation ◽  
Infarct Size ◽  
Lithium Chloride ◽  
Spontaneously Hypertensive Rats ◽  
Partial Recovery ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Mitochondrial Permeability ◽  
Isolated Hearts ◽  
Mnsod Activity

The aim of this study was to examine the effects of GSK-3βinhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia (GI) and 1-hour reperfusion (R); PRE: a cycle of 5 min GI and 10 minutes of R prior to 45 min GI; POS: three cycles of 30 sec GI/30 sec R at the start of R. Other hearts received lithium chloride (LiCl) or indirubin-3′-monoxime,5-iodo-(IMI) as GSK-3βinhibitors. All interventions reduced the infarct size observed in IC group. The expressions of P-GSK-3βand P-Akt decreased in IC and were restored after PRE, POS, and GSK-3βinhibitors treatments. An increase of cytosolic MnSOD activity and lipid peroxidation and a decrease of GSH content observed in IC hearts were attenuated in PRE, POS, and LiCl or IMI treatments. An increase of P-GSK-3β/VDAC physical association and a partial recovery of mitochondrial permeability were also detected after interventions. These data show that, in SHR hearts, GSK-3βinhibitors mimic the cardioprotection afforded by PRE and POS and suggest that a decrease in mitochondrial permeability mediated by P-GSK-3β/VDAC interaction is a crucial event.

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