Evaluation of factors in a primary care setting which may cause failure to respond to oral iron treatment in iron deficiency anaemia patients

2016 ◽  
Vol 8 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Linda Tahaineh ◽  
Nehad M. Ayoub ◽  
Adi H. Khassawneh
Keyword(s):  
Primary Care ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Care Setting ◽  
Primary Care Setting ◽  
Oral Iron ◽  
Deficiency Anaemia ◽  
Iron Treatment

scholarly journals Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hafid O. Al-Hassi ◽  
Oliver Ng ◽  
Rayko Evstatiev ◽  
Manel Mangalika ◽  
Natalie Worton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Metabolism ◽  
Iron Deficiency Anaemia ◽  
Iron Transport ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Loading ◽  
Deficiency Anaemia ◽  
Iron Treatment

AbstractOral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.

Comparison of the effects of oral iron treatment every day and every other day in female patients with iron deficiency anaemia

2020 ◽  
Vol 50 (7) ◽  
pp. 854-858
Author(s):  
Nur Düzen Oflas ◽  
Sinan Demircioğlu ◽  
Narin Yıldırım Doğan ◽  
Elife Eker ◽  
Ali Kutlucan ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Oral Iron ◽  
Deficiency Anaemia ◽  
Female Patients ◽  
Iron Treatment

Simple test for ingested iron

1966 ◽  
Vol 4 (25) ◽  
pp. 100-100
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Oral Iron ◽  
Confirmatory Test ◽  
Simple Test ◽  
Deficiency Anaemia ◽  
Experienced Observer

A surprisingly high proportion of patients do not take the drugs prescribed for them,1 and failure of iron deficiency anaemia to respond to oral iron is often due to failure to take the medication. An experienced observer can often tell from the appearance of the stools whether a patient is taking iron, but a simple objective confirmatory test may be needed. Such a test has recently been described.2

scholarly journals Intravenous versus oral iron therapy in treatment of postpartum anaemia

2017 ◽  
Vol 6 (8) ◽  
pp. 3454
Author(s):  
Neelima Agarwal ◽  
Preeti Sharma
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Hemoglobin Level ◽  
Oral Iron ◽  
Chi Square ◽  
Deficiency Anaemia ◽  
Significant Difference ◽  
Red Cell Indices

Background: Postpartum iron deficiency anaemia (IDA) is common in women. Most women are treated with either oral iron supplementation or blood transfusion. Hence, the aim of our study was to compare the effect of treatment with either oral ferrous sulphate or intravenous ferrous sucrose on postpartum IDA.Methods: 100 postpartum women with proven iron deficiency anaemia with hemoglobin <9gm/dl and serum ferritin <15 µgm/l were included in the study. They were randomized to receive either oral ferrous sulphate 200 mg twice daily for 6 weeks (group 1) or intravenous ferrous sucrose 200 mg, two to three doses given on alternate days (group 2). Total iron deficit was calculated using a standard formula. Target hemoglobin was 11 gm/dl. Results were analysed by the students t-test and chi-square test. Hemoglobin, hematocrit, red cell indices and ferritin were measured on day 2-3, 1-2 weeks and 6 weeks postpartumResults: By 1-2 weeks, hemoglobin level in women treated with intravenous iron had risen from 7.81±0.849 to 9.88±0.760 gm/dl which was more than those treated with oral iron (p<0.01); although by 6 weeks, there was no significant difference between the two groups. Ferritin levels rose rapidly in those treated with intravenous iron and remained significantly higher than in those treated with oral iron (p<0.01).Conclusions: Intravenous iron sucrose increases the hemoglobin level more rapidly than oral ferrous sulphate in women with postpartum IDA. It also replenishes iron stores more rapidly. 

Intravenous or oral iron for treating iron deficiency anaemia during pregnancy: systematic review and meta‐analysis

2019 ◽  
Vol 211 (8) ◽  
pp. 367-373 ◽  
Author(s):  
Alaa Qassim ◽  
Rosalie M Grivell ◽  
Amanda Henry ◽  
Giselle Kidson‐Gerber ◽  
Antonia Shand ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Meta Analysis ◽  
Oral Iron ◽  
Deficiency Anaemia

Epidemiology of iron deficiency anaemia in four European countries: a population-based study in primary care

2016 ◽  
Vol 97 (6) ◽  
pp. 583-593 ◽  
Author(s):  
Miriam Levi ◽  
Matteo Rosselli ◽  
Monica Simonetti ◽  
Ovidio Brignoli ◽  
Maurizio Cancian ◽  
...  
Keyword(s):  
Primary Care ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Population Based ◽  
European Countries ◽  
Population Based Study ◽  
Deficiency Anaemia
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