Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

2017 ◽  
Vol 69 (11) ◽  
pp. 1477-1484 ◽  
Author(s):  
Anna Justina Svagan ◽  
Anette Müllertz ◽  
Korbinian Löbmann
Keyword(s):  
Sustained Release ◽  
Soluble Model ◽  
Poorly Soluble ◽  
Model Drug

Precipitation of a Poorly Soluble Model Drug during In Vitro Lipolysis: Characterization and Dissolution of the Precipitate

2010 ◽  
Vol 99 (12) ◽  
pp. 4982-4991 ◽  
Author(s):  
Philip J. Sassene ◽  
Matthias M. Knopp ◽  
Janne Z. Hesselkilde ◽  
Vishal Koradia ◽  
Anne Larsen ◽  
...  
Keyword(s):  
In Vitro Lipolysis ◽  
Soluble Model ◽  
Poorly Soluble ◽  
Model Drug

scholarly journals Stabilization benefits of single and multi-layer self-nanoemulsifying pellets: A poorly-water soluble model drug with hydrolytic susceptibility

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0198469
Author(s):  
Ahmad Abdul-Wahhab Shahba ◽  
Fars Kaed Alanazi ◽  
Sayed Ibrahim Abdel-Rahman
Keyword(s):  
Water Soluble ◽  
Soluble Model ◽  
Poorly Water Soluble ◽  
Model Drug

Polylactic Acid–Graphene Oxide-based Materials for Loading and Sustained Release of Poorly Soluble Pesticides

Langmuir ◽  
2020 ◽  
Vol 36 (41) ◽  
pp. 12336-12345
Author(s):  
Ya Wang ◽  
Chaonan Li ◽  
Ting Wang ◽  
Xinwen Li ◽  
Xiaogang Li
Keyword(s):  
Graphene Oxide ◽  
Sustained Release ◽  
Polylactic Acid ◽  
Poorly Soluble

scholarly journals Low-Surfactant Microemulsions for Enhanced Topical Delivery of Poorly Soluble Drugs

2011 ◽  
Vol 14 (3) ◽  
pp. 315 ◽  
Author(s):  
Alireza Shalviri ◽  
Avinash C Sharma ◽  
Dipak Patel ◽  
Amyn Sayani
Keyword(s):  
Drug Release ◽  
Xanthan Gum ◽  
Colloidal Silica ◽  
Topical Delivery ◽  
Silica Gels ◽  
Poorly Soluble Drugs ◽  
Release Rates ◽  
Significant Difference ◽  
Poorly Soluble ◽  
Model Drug

Purpose: To develop and characterize low-surfactant microemulsion (ME) gels to enhance topical delivery of poorly soluble drugs. Method: Five low surfactant ME formulations were manufactured following the construction of pseudo-ternary phase diagrams. The MEs were screened for their ability to dissolve a poorly soluble new chemical entity (Model Drug X). Various viscosity imparting agents like Carbopol 934, Colloidal Silica, HPMC K100M, Lubrajel NP, and Xanthan Gum were evaluated for the manufacture of these ME gels. Each ME gel was then further evaluated for physical stability, including assessing rheological profiles. In vitro release profiles were also determined and compared to a conventional ointment. Results: Three of the five low surfactant MEs developed (ME1, ME4 and ME5) were capable of dissolving Model Drug X up to 14 fold higher than the conventional ointment formulation. ME1 and ME4 gels comprising Xanthan gum or Carbopol 934 were physically stable, while ME5 gel was stable only with Colloidal Silica. The ME5 gel with Colloidal Silica showed an irreversible increase in its elastic modulus when exposed to high temperature, indicating that the formulation would be less suitable for commercial use. The Xanthan Gum and Colloidal Silica gels yielded significantly higher release rates (8 - 10 fold) compared to a conventional ointment and formulations containing Carbopol 934. The significant difference in drug release rates between Xanthan Gum and Carbopol 934 indicated that choice of viscosity imparting agent played an important role in governing drug release from ME gels. Conclusion: ME gels were developed with low surfactant concentrations and improved formulation characteristics, which increased the solubility and subsequent release of a poorly soluble drug. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation

2018 ◽  
Vol 8 (6-s) ◽  
pp. 5-8 ◽  
Author(s):  
Rinshi Agrawal ◽  
RK Maheshwari
Keyword(s):  
Drug Loading ◽  
Research Work ◽  
Water Soluble ◽  
Dsc Studies ◽  
Water Soluble Drug ◽  
Poorly Soluble ◽  
Poorly Water Soluble ◽  
Poorly Soluble Drug ◽  
Model Drug ◽  
Poorly Water Soluble Drug

Application of mixed solvency has been employed in the present research work to develop a liquisolid system (Powder formulation) of poorly water soluble drug, cefixime (as model drug). Material and Methods: For poorly water soluble drug cefixime, combination of solubilizers such as sodium acetate, sodium caprylate and propylene glycol as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility and thereby resulting in enhanced drug loading capacity of cefixime. The procured sample of cefixime was characterized by melting point, IR, UV and DSC studies. Stability studies of liquisolid system of cefixime were performed for two months at room temperature, 30˚C and 40˚C. All the formulations were physically, chemically, and microbiologically stable. Conclusion: Mixed solvency concept has been successfully employed for enhancing the drug loading of poorly water soluble drug, cefixime. Keywords: Solubility, cefixime, liquisolid system, mixed solvency concept.

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