Use of Core-Cross-Linked Polymeric Micelles Induced by the Selective Detection of Cu(II) Ions for the Sustained Release of a Model Drug

2019 ◽  
Vol 11 (15) ◽  
pp. 14368-14375 ◽  
Author(s):  
Jae Min Bak ◽  
Hyung-il Lee
Keyword(s):  
Sustained Release ◽  
Polymeric Micelles ◽  
Selective Detection ◽  
Model Drug

The development of unimolecular conjugated polymeric micelles for the highly selective detection and recovery of gold from electronic waste

2019 ◽  
Vol 43 (30) ◽  
pp. 11811-11815 ◽  
Author(s):  
Jilin Liu ◽  
Ting Yang ◽  
Zhiru Hu ◽  
Guodong Feng
Keyword(s):  
Carbon Dioxide ◽  
Sustainable Development ◽  
Development Strategy ◽  
Conjugated Polymer ◽  
Carbon Dioxide Emissions ◽  
Polymeric Micelles ◽  
Electronic Waste ◽  
Selective Detection

Gold recycling is a sustainable development strategy that will save a large amount of carbon dioxide emissions. In this work, we have developed a conjugated polymer, that can not only detect Au content in e-waste but also extract Au from e-waste.

Fluorescent Polymeric Micelles with Tetraphenylethylene Moieties and Their Application for the Selective Detection of Glucose

2012 ◽  
Vol 12 (11) ◽  
pp. 1583-1590 ◽  
Author(s):  
Xiang Shen ◽  
Yi Shi ◽  
Bo Peng ◽  
Kan Li ◽  
Junfeng Xiang ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Selective Detection

Polymeric micelles based on photocleavable linkers tethered with a model drug

Polymer ◽  
2014 ◽  
Vol 55 (6) ◽  
pp. 1436-1442 ◽  
Author(s):  
Ji-Eun Lee ◽  
Eungjin Ahn ◽  
Jae Min Bak ◽  
Seo-Hyun Jung ◽  
Jong Mok Park ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Model Drug

scholarly journals Inulin-Grafted Stearate (In-g-St) as the Effective Self-Assembling Polymeric Micelle: Synthesis and Evaluation for the Delivery of Betamethasone

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Gholamabbas Chehardoli ◽  
Parham Norouzian ◽  
Farzin Firozian
Keyword(s):  
Zeta Potential ◽  
Sustained Release ◽  
Targeted Delivery ◽  
Encapsulation Efficiency ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Polymeric Micelle ◽  
Water Soluble ◽  
Burst Release ◽  
Potential Measurement

Background. Betamethasone as a corticosteroid drug is commonly used for the treatment of rheumatoid arthritis. Unfortunately, betamethasone is a low water-soluble drug and its efficacy is low. So an attractive strategy is the targeted delivery of betamethasone to the damaged joint using polymeric micelle-based carriers. Methods. Inulin-grafted stearate (In-g-St) was synthesized via the reaction of stearoyl chloride and inulin, then characterized by FT-IR and H-NMR. In-g-St forms micelles in the presence of betamethasone. The prepared polymeric micelles were characterized for size, zeta potential, drug loading, particles’ morphology, critical micelle concentration (CMC), and encapsulation efficiency. So sustained release polymeric micelles of betamethasone were developed by employing In-g-St. Results. The measurement of particle size showed a mean diameter of 60 and 130 nm for 10% and 20% drug-loaded micelles, respectively, and SEM showed that the particle’s morphologies are spherical. Zeta potential measurement for the drug-containing micelles showed a value of -11.8 mV. Drug loading efficiency and the encapsulation efficiency were 6.36% and 63.6%, as well as 18.97% and 94.88% for 10% and 20%, respectively. 20% drug-loaded polymer showed a small burst release of betamethasone at the first 3 h which was followed by sustained release in the next 24 h. Furthermore, the formula with 10% exhibited good sustained release properties except for the minor initial burst release. Conclusion. Data from the zeta potential, CMC, drug loading capacity, and in vitro drug release studies indicated that In-g-St polymeric micelles can be suitable candidates for the efficient delivery of hydrophobic drugs like betamethasone.

Self-assemble Amphiphilic PEO-PPO-PEO Tri-block Co-polymeric Methotrexate Nanomicelles to Combat Against MCF7 Cancer Cells

2020 ◽  
Vol 17 ◽  
Author(s):  
Manoj Kumar Mishra ◽  
Jitendra Gupta ◽  
Reena Gupta
Keyword(s):  
Sustained Release ◽  
Partition Coefficient ◽  
Cancer Cells ◽  
Intravenous Administration ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
Sds Micelles

Background: Methotrexate (MTX) is a water-insoluble, anti-tumor agent, causes adverse effects like bone marrow suppression, chronic interstitial obstructive pulmonary disease, hepatotoxicity, leukopenia, interstitial pneumonitis and nephrotoxicity with slow drug release rate. Objective: The present study was aimed for successfully incorporating of MTX into novel-targeted Pluronic (PEO-PPOPEO tri-block co-polymer) F127 polymeric micelles intended for intravenous administration with improved drug loading and sustained release behavior necessary to achieve better efficacy of MTX. Method: MTX-loaded Pluronic F127 micelles were characterized for critical micelle concentration, particle size and zeta potential, 1H NMR, drug loading, encapsulation efficiency characterization, cell uptake, in-vitro release study along with partition coefficient and solubilization thermodynamics. Results: The micellar formulation resulted in nano size 27.32±1.43nm of PF127/SDS, as compared to Pluronic F127 micelles or PF127/Phosphatidyl choline which were 30.52±1.18nm and 154.35±5.5nm respectively. The uptake of PF127/SDS micellar formulation incorporating Rhodamine 123 in MCF7 cancer cells was found to be higher (84.25%) than PF127/PC, PF127 and MTX i.e. 66.26%, 73.59% and 53% respectively. The in-vitro MTX release from PF127, PF127/SDS and PF127/PC polymeric micelles formulations was observed 69%, 69.5% and 66% at 12 h whereas 80.89%, 77.67% and 78.54% after 24 h respectively and reveals sustained release. MTX loaded PF127/SDS micelles showed high Partition coefficient and negative free energy of solubilization compared to PF127 and PF127/PC which signifies self-assembly behavior and thermodynamic stability towards dissociation to be higher. Conclusion: Finally concluded that MTX loaded PF127/SDS micelles act as a potential anticancer delivery system in comparison to PF127/PC and PF127 to combat against tumor cells by enhancing its cellular uptake targeting with sustained release pattern and reducing the thermodynamic instability. Thus, PF127/SDS micellar formulation can provide a useful alternative dosage form for intravenous administration of MTX.

Formulation Development and Evaluation of Fast Disintegrating Sustained Release Pellets Containing Verapamil Hydrochloride Tablets by Fluidized Bed Processor

2021 ◽  
pp. 261-266
Author(s):  
Jagruti J. Pansare ◽  
Rajendra K. Surawase
Keyword(s):  
Sustained Release ◽  
Fluidized Bed ◽  
Extended Period ◽  
Coating Film ◽  
Formulation Development ◽  
Eudragit Rs 30D ◽  
Fast Disintegrating Tablet ◽  
Model Drug ◽  
Verapamil Hcl ◽  
Tablet Hardness

This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.

Synthesis and characterization of an amphiphilic methoxy poly(l-lactide)-block-poly(glycidylmethacrylate) copolymer as a drug nanocarrier

e-Polymers ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Massoumeh Bagheri ◽  
Forough Motirasoul
Keyword(s):  
Diblock Copolymer ◽  
Ring Opening ◽  
Polymeric Micelles ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Transmission Electron ◽  
Model Drug ◽  
Dialysis Bag

AbstractPresent research is a preliminary report on the amphiphilic diblock copolymer (mPLA-b-PGMA) comprising hydrophobic methoxy poly(L-lactide) (mPLA) and hydrophilic poly(glycidyl methacrylate) (PGMA) segments was used as a promising drug carrier. Diblock copolymer was synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) methods. Methanol first initiated ROP of L-lactide in the presence of tin(II)bis(2-ethylhexanoate) (Sn(oct)2) as a catalyst. The resulting monohydroxyl-terminated polylactic acid (mPLA) was subsequently converted to a bromine-ended macroinitiator (mPLA-Br) by esterification with 2-bromisobutyryl bromide. The copolymer mPLA-b-PGMA was synthesized in a subsequent ATRP of GMA. The obtained polymers were characterized by means of 1H NMR, FTIR, DSC and TGA. The copolymer mPLA-b- PGMA self-assembled into nanoscale micelles in aqueous solutions, as investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The TEM image of polymeric micelles showed that the micelles were spherical in shape and that their diameters were in the range of 80-140 nm. Then by using the naproxen as a hydrophobic model drug, the drug-loaded micelles with 81.18 % loading efficiency and 16.24 % loading capacity were prepared. Moreover, in vitro release study of naproxen was performed using dialysis bag in phosphate-buffered solution at 37°C and pH at 7.4. Accordingly, these polymeric micelles may provide as an effective drug carrier for controlled drug release.

scholarly journals Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co-depsipeptide) Block Copolymers

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Akihiro Takahashi ◽  
Yuta Ozaki ◽  
Akinori Kuzuya ◽  
Yuichi Ohya
Keyword(s):  
Block Copolymers ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Polymeric Micelle ◽  
Molecular Weights ◽  
The Core ◽  
Drug Delivery Carrier ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Model Drug

We synthesized series of amphiphilic AB-type block copolymers having systematic variation in the core-forming segments using poly(lactide-co-depsipeptide)s as a hydrophobic segment and prepared polymeric micelles using the block copolymers, PEG-b-poly(lactide-co-depsipeptide). We then discussed the relationship between the core-forming segment structure and drug loading efficiency for the polymeric micelles. PEG-b-poly(lactide-co-depsipeptide)s, PEG-b-PLGL containingl-leucine (Leu), and PEG-b-PLGF containingl-phenylalanine (Phe), with similar molecular weights and various mole fractions of depsipeptide units, were synthesized. Polymeric micelles entrapping model drug (fluorescein, FL) were prepared using these copolymers. As a result, PEG-b-poly(lactide-co-depsipeptide) micelles showed higher drug loading compared with PEG-b-PLLA and PEG-b-PDLLA as controls. The drug loading increased with increase in the mole fraction of depsipeptide unit in the hydrophobic segments. The introduction of aliphatic and aromatic depsipeptide units was effective to achieve higher FL loading into the micelles. PEG-b-PLGL micelle showed higher drug loading than PEG-b-PLGF micelle when the amount of FL in feed was high. These results obtained in this study should be useful for strategic design of polymeric micelle-type drug delivery carrier with high drug loading efficiency.

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