Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review

2014 ◽  
Vol 67 (4) ◽  
pp. 473-485 ◽  
Author(s):  
Anna Herman ◽  
Andrzej P. Herman
Keyword(s):  
Drug Delivery ◽  
Essential Oils ◽  
Transdermal Drug Delivery ◽  
Skin Penetration ◽  
Penetration Enhancer

scholarly journals Transdermal patches fabricated from hyaluronic acid for the enhanced skin penetration of therapeutic entities

2019 ◽  
Vol 9 (1) ◽  
pp. 252-256
Author(s):  
Syam S. Nair
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Transdermal Drug Delivery ◽  
Skin Penetration ◽  
Sustained Delivery ◽  
Research Groups ◽  
Outermost Layer ◽  
Drug Molecules ◽  
Different Types ◽  
Transdermal Route

Skin is an attractive route for drug delivery. However poor permeation of drugs across the skin due to the presence of extremely ordered architecture of outermost layer of skin, led to several investigation to improve the permeability of drugs. Polysaccharides remain widely studied biomaterial for the sustained delivery of drug molecules across the skin. The advance of hyaluronic acid (HA) chemistry with multiple benefits has improved the attention of research groups for its application in the skin transportation of drug molecules. Beginning from the advantages of transdermal route, the present review details the application of HA in transdermal drug delivery. In the last few decades, substantial investigation in the domain has improved the requirement for an outline of all the developments, which is depicted in the review. The review also presented different types of HA based transdermal devices such as transferosomes, nanoemulsions, microneedle etc and their potential to improve the transdermal drug delivery. Furthermore the application of HA through chemical modification as a potential transdermal device is also presented. Keywords: Hyaluronic acid, transdermal drug delivery, microneedles, nanoemulsion, hydrogel

scholarly journals Microneedle Array Patches: Characterization and in -vitro Evaluation

2021 ◽  
Vol 30 (1) ◽  
pp. 66-75
Author(s):  
Zainab A. Sadeq
Keyword(s):  
Drug Delivery ◽  
Blood Vessel ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Solid Polymer ◽  
Microneedle Array ◽  
Microneedle Patch ◽  
Novel Drug

 Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration developed named as microneedle.  Microneedle drug delivery system is a novel drug delivery to overcome the limitation of TDDS like skin barrier restriction for large molecule. Microneedle patch can penetrate through skin subcutaneous into epidermis, avoiding nerve fiber and blood vessel contact. There are many type of microneedle patch like solid, polymer, hallow, hydrogel forming microneedle and dissolving microneedle with different method of microfabrication

scholarly journals A Comprehensive Review on Natural Products as Chemical Penetration Enhancer

2021 ◽  
Vol 11 (5-S) ◽  
pp. 176-187
Author(s):  
Sudip Das ◽  
Koushik Sen Gupta
Keyword(s):  
Drug Delivery ◽  
Natural Products ◽  
Transdermal Drug Delivery ◽  
Skin Irritation ◽  
Penetration Enhancer ◽  
Penetration Enhancers ◽  
Topical Drug Delivery ◽  
Permeation Enhancers ◽  
In Vivo Models

The drug delivery within the stratum corneum of the skin prevails a challenging area for the pharmaceutical field, especially to the formulation scientists. Several investigations revealed that the lipid domain, which is the integral component of the transport barrier, must be breached if it is to be delivered transdermally at an appropriate rate. In particular, transdermal drug delivery has intrigued researchers with multiple suggestions because multiple dosing or insufficient drug delivery or characteristics of various drugs often results in low therapeutic effects. The application of permeation or penetration enhancers may prolong the number of drugs that can be offered topically. The application of any natural permeation enhancer is innoxious over the artificial permeation enhancers. The natural permeation enhancers are investigated, so notably include essential oils, terpenes, terpenoids, fatty acid esters, etc., have a certain effect in the transdermal drug delivery system. Despite decades of investigation on the natural chemical penetration enhancer, the researchers could not establish the effectiveness of natural penetration enhancers clinically due to the lack of in vivo models. Several factors, like solubility, solvent selection, experimental models, etc., has restricted the application and development of natural penetration enhancers in topical drug delivery systems, especially in the patches. Therefore, further investigation needs to do on skin irritation to decide natural penetration enhancers controlling optimum enhancement effects with minimal skin irritation. This review gives a comprehensive literature survey on naturally obtained chemical penetration enhancers and their future possibilities. Keywords: Topical Drug delivery system, Natural products, Penetration enhancer, Stratum corneum, In vivo models.

Transdermal Drug delivery: A step towards treatment of cancer

2021 ◽  
Vol 16 ◽  
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Penetration ◽  
Delivery Systems ◽  
New Developments ◽  
Transdermal Drug Delivery Systems ◽  
Transdermal Route

Background: Transdermal drug delivery is an emerging and tempting system over oral and hypodermic drug delivery system. With the new developments in skin penetration techniques, anticancer drugs ranging from hydrophilic macromolecules to lipophilic drugs can be administered via transdermal route to treat cancer. Objective: In the present review, various approaches to enhance the transdermal delivery of drugs is discussed including the micro and nanotechnology based transdermal formulations like chemotherapy, gene therapy, immunotherapy, phototherapy, vaccines and medical devices. Limitations and advantages of various transdermal technologies is also elaborated. Method: In this review, patent applications and recent literature of transdermal drug delivery systems employed to cure mainly cancer are covered. Results: Transdermal drug delivery systems have proved their potential to cure cancer. They increase the bioavailability of drug by site specific drug delivery and can reduce the side effects/toxicity associated with anticancer drugs. Conclusion: The potential of transdermal drug delivery systems to carry the drug may unclutter novel ways for therapeutic intercessions in various tumors.

scholarly journals Synthesis and Assessment of a New Tetrahydrogeraniol Derivative as Penetration Enhancer for Transdermal Drug Delivery

2016 ◽  
Vol 1 (1) ◽  
pp. 45-53
Author(s):  
Amjad Khan ◽  
Muhammad Hanif Raja ◽  
Arshad Khan ◽  
Muhammad Wasim Khan ◽  
Gul Majid Khan
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Penetration Enhancer

scholarly journals Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

2020 ◽  
Vol 88 (2) ◽  
pp. 17 ◽  
Author(s):  
Daniélle van Staden ◽  
Jeanetta du Plessis ◽  
Joe Viljoen
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Ternary Phase ◽  
Ternary Phase Diagram ◽  
Skin Penetration ◽  
Delivery Systems ◽  
Phase Behaviour ◽  
Limited Attention ◽  
Evaluation Strategies

Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery possibilities presented by these uniquely simplified systems in terms of muco-adhesiveness and zeta-potential changing capacity lead the way forward to ground-breaking research. Contrarily, SEDDSs destined for topical/transdermal drug delivery have received limited attention. Therefore, this review is focused at utilising principles, established during development of oral SEDDSs, and tailoring them to fit evaluation strategies for an optimised topical/transdermal drug delivery vehicle. This includes a detailed discussion of how the authentic pseudo-ternary phase diagram is employed to predict phase behaviour to find the self-emulsification region most suitable for formulating topical/transdermal SEDDSs. Additionally, special attention is given to the manner of characterising oral SEDDSs compared to topical/transdermal SEDDSs, since absorption within the gastrointestinal tract and the multi-layered nature of the skin are two completely diverse drug delivery territories. Despite the advantages of the topical/transdermal drug administration route, certain challenges such as the relatively undiscovered field of skin metabolomics as well as the obstacles of choosing excipients wisely to establish skin penetration enhancement might prevail. Therefore, development of topical/transdermal SEDDSs might be more complicated than expected.

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