Pharmacokinetics of oral versus intravenous ibuprofen for closure of patent ductus arteriosus: A pilot randomised controlled study

2021 ◽  
Author(s):  
Priyantha Ebenezer Edison ◽  
Sylvia Chen ◽  
Cheo Lian Yeo ◽  
John C Allen ◽  
Woei Bing Poon ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Controlled Study ◽  
Randomised Controlled Study ◽  
Randomised Controlled ◽  
Intravenous Ibuprofen ◽  
Patent Ductus

scholarly journals Comparison of the effect of two drugs paracetamol with intravenous ibuprofen in patent ductus arteriosus treatment

2020 ◽  
Vol 9 (5) ◽  
pp. 690
Author(s):  
Mehrdad Mirzarahimi ◽  
Ramin Emamzadeghan ◽  
Afsaneh Enteshari Moghaddam ◽  
Narges Falsafi
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Alternative Therapy ◽  
Cyclooxygenase Inhibitors ◽  
Arterial Duct ◽  
Intravenous Paracetamol ◽  
Liver Parameters ◽  
Intravenous Ibuprofen ◽  
Patent Ductus

Background: Patent ductus arteriosus (PDA) is a common cause of morbidity and mortality among premature infants that affects more than 40% of them. PDA treatment includes medical and surgical treatment. Most drugs used to block PDA are cyclooxygenase inhibitors (ibuprofen and indomethacin). The role of paracetamol as an alternative therapy in PDA ligation has been considered in recent years due to the potential side effects of cyclooxygenase inhibitors.Methods: Patients in the first group were treated with intravenous paracetamol at a dose of 15 mg/kg every 6 hours for three days and the second group was treated with intravenous ibuprofen at a daily dose of 10 mg/kg daily and 5 mg/kg for the second and third days. At the end of the treatment period (day 3), they underwent echocardiography again. If the echocardiographic findings indicated no closure of the arterial duct, patients were treated with the aforementioned drug for another period and rechecked at the end of the third day, and at each stage required information was collected.Results: Arterial duct closure in paracetamol group was 96.7% and in ibuprofen group was 100%. The effects of both paracetamol and ibuprofen were similar in terms of renal parameters but in terms of effects on liver parameters. The effect of paracetamol on all liver parameters except aspartate transaminase (AST) was significant, but ibuprofen was able to affect only bilirubin among liver parameters and had no significant effect on both AST and alanine aminotransferase, parameters.Conclusions: Results showed that both paracetamol and ibuprofen are effective in treating of PDA and had similar impact.

Comparison of Oral and Intravenous Ibuprofen for Medical Closure of Patent Ductus Arteriosus: Which One Is Better?

2012 ◽  
Vol 7 (6) ◽  
pp. 534-543 ◽  
Author(s):  
Ozgur Olukman ◽  
Sebnem Calkavur ◽  
Gulten Ercan ◽  
Fusun Atlihan ◽  
Taliha Oner ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Intravenous Ibuprofen ◽  
Patent Ductus

scholarly journals 225 Oral Vs Intravenous Ibuprofen for Treatment of Patent Ductus Arteriosus

2010 ◽  
Vol 68 ◽  
pp. 117-118
Author(s):  
Mungan I Akin ◽  
E Okulu ◽  
B Atasay ◽  
S Arsan ◽  
E Tutar ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Intravenous Ibuprofen ◽  
Patent Ductus
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