scholarly journals Comparison of cranial ultrasound and MRI for detecting brain injury in extremely preterm infants and correlation with long-term neurological outcomes

2017 ◽  
Vol 53 ◽  
pp. 17-17
Keyword(s):  
Brain Injury ◽  
Preterm Infants ◽  
Cranial Ultrasound ◽  
Neurological Outcomes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Preventing Brain Injury in the Preterm Infant—Current Controversies and Potential Therapies

2021 ◽  
Vol 22 (4) ◽  
pp. 1671
Author(s):  
Nathanael Yates ◽  
Alistair J. Gunn ◽  
Laura Bennet ◽  
Simerdeep K. Dhillon ◽  
Joanne O. Davidson
Keyword(s):  
Cerebral Palsy ◽  
Brain Injury ◽  
Preterm Infant ◽  
Brain Damage ◽  
Preterm Infants ◽  
Preclinical Studies ◽  
Recombinant Erythropoietin ◽  
Neurological Outcomes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Preterm birth is associated with a high risk of morbidity and mortality including brain damage and cerebral palsy. The development of brain injury in the preterm infant may be influenced by many factors including perinatal asphyxia, infection/inflammation, chronic hypoxia and exposure to treatments such as mechanical ventilation and corticosteroids. There are currently very limited treatment options available. In clinical trials, magnesium sulfate has been associated with a small, significant reduction in the risk of cerebral palsy and gross motor dysfunction in early childhood but no effect on the combined outcome of death or disability, and longer-term follow up to date has not shown improved neurological outcomes in school-age children. Recombinant erythropoietin has shown neuroprotective potential in preclinical studies but two large randomized trials, in extremely preterm infants, of treatment started within 24 or 48 h of birth showed no effect on the risk of severe neurodevelopmental impairment or death at 2 years of age. Preclinical studies have highlighted a number of promising neuroprotective treatments, such as therapeutic hypothermia, melatonin, human amnion epithelial cells, umbilical cord blood and vitamin D supplementation, which may be useful at reducing brain damage in preterm infants. Moreover, refinements of clinical care of preterm infants have the potential to influence later neurological outcomes, including the administration of antenatal and postnatal corticosteroids and more accurate identification and targeted treatment of seizures.

Factors associated with long-term mechanical ventilation in extremely preterm infants

2018 ◽  
Vol 11 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Lina Yossef ◽  
Edward G. Shepherd ◽  
Susan Lynch ◽  
Kristina M. Reber ◽  
Leif D. Nelin
Keyword(s):  
Mechanical Ventilation ◽  
Preterm Infants ◽  
Factors Associated ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Short- and Long-Term Outcomes of Extremely Preterm Infants in Japan According to Outborn/Inborn Birth Status*

2019 ◽  
Vol 20 (10) ◽  
pp. 963-969 ◽  
Author(s):  
Yoshihito Sasaki ◽  
Kaoru Ishikawa ◽  
Akira Yokoi ◽  
Tomoaki Ikeda ◽  
Kazuo Sengoku ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Long Term Outcomes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Short And Long Term

scholarly journals Bronchopulmonary Dysplasia: Can We Agree on a Definition?

2018 ◽  
Vol 35 (06) ◽  
pp. 537-540 ◽  
Author(s):  
Deepak Jain ◽  
Eduardo Bancalari
Keyword(s):  
Respiratory Failure ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Nasal Cannula ◽  
Clinical Practices ◽  
Unique Challenge ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Respiratory Outcomes

AbstractThe advances in obstetric and neonatal care over the last half century have resulted in changes in pathophysiology and clinical presentation of bronchopulmonary dysplasia (BPD). In contrast to the original description of BPD by Northway et al as a severe lung injury in relatively mature preterm infants, the most common form of BPD currently is characterized by chronic respiratory insufficiency in extremely preterm infants. This evolution in the presentation of BPD, along with changes in respiratory support strategies such as increased use of nasal cannula oxygen, has presented a unique challenge to find a definition that describes the severity of lung damage and predict the long-term respiratory outcomes with some accuracy.The limitations of current definitions of BPD include inconsistent correlation with long-term respiratory outcomes, inability to classify infants dying from severe respiratory failure prior to 36 weeks' postmenstrual age, and potential inappropriate categorization of infants on nasal cannula oxygen or with extrapulmonary causes of respiratory failure. In the long term, the aim for a new definition of BPD is to develop a classification based on the pathophysiology and objective lung function evaluation providing a more accurate assessment for individual patients. Until then, a consensus definition that encompasses current clinical practices, provides reasonable prediction of later respiratory outcomes, and is relatively simple to use should be achieved.

Early inhaled budesonide in extremely preterm infants decreases long‐term respiratory morbidity

2020 ◽  
Vol 55 (5) ◽  
pp. 1124-1130 ◽  
Author(s):  
Jana Tukova ◽  
Jan Smisek ◽  
Blanka Zlatohlavkova ◽  
Richard Plavka ◽  
Daniela Markova
Keyword(s):  
Preterm Infants ◽  
Respiratory Morbidity ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Inhaled Budesonide

scholarly journals Cranial ultrasound and MRI at term age in extremely preterm infants

2009 ◽  
Vol 95 (5) ◽  
pp. F310-F314 ◽  
Author(s):  
S. Horsch ◽  
B. Skiold ◽  
B. Hallberg ◽  
B. Nordell ◽  
A. Nordell ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Cranial Ultrasound ◽  
Extremely Preterm ◽  
Extremely Preterm Infants
Sign in / Sign up

Export Citation Format

Share Document