scholarly journals Establishing an ovine model of congenital diaphragmatic hernia to evaluate neonatal transition at birth

2017 ◽  
Vol 53 ◽  
pp. 52-52
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model ◽  
Neonatal Transition

Impact of Congenital Diaphragmatic Hernia on Lung Development: Parenchymal and Vascular Changes in an Ovine Model

2002 ◽  
Vol 103 (s47) ◽  
pp. 53P-53P
Author(s):  
SM Nelson ◽  
CA Hajivassiliou ◽  
AD Cameron ◽  
G Haddock ◽  
P Dunkley ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Lung Development ◽  
Vascular Changes ◽  
Ovine Model

Phospholipid Profile of Amniotic Fluid in Ovine Model of Congenital Diaphragmatic Hernia (CDH): The Effect of Fetal Tracheal Occlusion

2015 ◽  
Vol 14 (3) ◽  
pp. 1465-1471 ◽  
Author(s):  
Maria Chiara Mimmi ◽  
Maurizio Ballico ◽  
Francesco Amoroso ◽  
Valeria Calcaterra ◽  
Mario Marotta ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model ◽  
Tracheal Occlusion ◽  
Phospholipid Profile

scholarly journals Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia

2021 ◽  
Vol 9 ◽  
Author(s):  
Philip L. J. DeKoninck ◽  
Emily J. J. Horn-Oudshoorn ◽  
Ronny Knol ◽  
Kelly J. Crossley ◽  
Irwin K. M. Reiss
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Transition Period ◽  
Adverse Outcomes ◽  
Lung Hypoplasia ◽  
Future Research ◽  
Knowledge Gaps ◽  
Physiological Adaptations ◽  
Interesting Approach ◽  
Neonatal Transition

Clinical research for infants born with a congenital diaphragmatic hernia (CDH) has until recently mainly focused on advances in prenatal and postnatal treatment. However, during the early perinatal transition period there are major physiological adaptations. For most infants these changes will happen uneventfully, but for CDH infants this marks the beginning of serious respiratory complications. In recent years, there is emerging evidence that the clinical management during the perinatal stabilization period in the delivery room may influence postnatal outcomes. Herein, we discuss major knowledge gaps and novel concepts that aim to optimize fetal to neonatal transition for infants with CDH. One such novel and interesting approach is performing resuscitation with an intact umbilical cord, the efficacy of this procedure is currently being investigated in several clinical trials. Furthermore, close evaluation of neonatal physiological parameters in the first 24 h of life might provide early clues concerning the severity of lung hypoplasia and the risk of adverse outcomes. We will provide an overview of trending concepts and discuss potential areas for future research.

scholarly journals BMP4 and LGL1 are Down Regulated in an Ovine Model of Congenital Diaphragmatic Hernia

2014 ◽  
Vol 1 ◽  
Author(s):  
Heather M. A. Emmerton-Coughlin ◽  
K. Kathryn Martin ◽  
Jacky S. S. Chiu ◽  
Lin Zhao ◽  
Leslie A. Scott ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model

Impaired endothelial cell nitric oxide signaling in an ovine model of congenital diaphragmatic hernia

2013 ◽  
Vol 217 (3) ◽  
pp. S83
Author(s):  
Shannon N. Acker ◽  
Gregory J. Seedorf ◽  
Jason Gien ◽  
Eva Nozik-Grayck ◽  
David A. Partrick ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cell ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model ◽  
Nitric Oxide Signaling

Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia

2019 ◽  
Vol 104 (6) ◽  
pp. F617-F623 ◽  
Author(s):  
Aidan J Kashyap ◽  
Kelly J Crossley ◽  
Philip L J DeKoninck ◽  
Karyn A Rodgers ◽  
Marta Thio ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Cerebral Oxygenation ◽  
Weight Ratio ◽  
Respiratory Acidosis ◽  
Tissue Oxygen Saturation ◽  
Lung Hypoplasia ◽  
Ovine Model ◽  
Lung Weight ◽  
Arterial Blood

ObjectiveInfants with a congenital diaphragmatic hernia (CDH) are at high risk of developing pulmonary hypertension after birth, but little is known of their physiological transition at birth. We aimed to characterise the changes in cardiopulmonary physiology during the neonatal transition in an ovine model of CDH.MethodsA diaphragmatic hernia (DH) was surgically created at 80 days of gestational age (dGA) in 10 fetuses, whereas controls underwent sham surgery (n=6). At 138 dGA, lambs were delivered via caesarean section and ventilated for 2 hours. Physiological and ventilation parameters were continuously recorded, and arterial blood gas values were measured.ResultsDH lambs had lower wet lung-to-body-weight ratio (0.016±0.002vs0.033±0.004), reduced dynamic lung compliance (0.4±0.1mL/cmH2O vs1.2±0.1 mL/cmH2O) and reduced arterial pH (7.11±0.05vs7.26±0.05), compared with controls. While measured pulmonary blood flow (PBF) was lower in DH lambs, after correction for lung weight, PBF was not different between groups (4.05±0.60mL/min/gvs4.29±0.57 mL/min/g). Cerebral tissue oxygen saturation was lower in DH compared with control lambs (55.7±3.5vs67.7%±3.9%).ConclusionsImmediately after birth, DH lambs have small, non-compliant lungs, respiratory acidosis and poor cerebral oxygenation that reflects the clinical phenotype of human CDH. PBF (indexed to lung weight) was similar in DH and control lambs, suggesting that the reduction in PBF associated with CDH is proportional to the degree of lung hypoplasia during the neonatal cardiopulmonary transition.

Sign in / Sign up

Export Citation Format

Share Document