Stereological Lung Parameters After Fetoscopic Abdominal Decompression of Congenital Diaphragmatic Hernia in an Ovine Model: A Pilot Study

2021 ◽  
Author(s):  
Robert Bergholz ◽  
Felipe Fromm ◽  
Andreas Meinzer ◽  
Christian Muehlfeld ◽  
Michael Boettcher ◽  
...  
Keyword(s):  
Pilot Study ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model ◽  
Abdominal Decompression

scholarly journals Fetoscopic abdominal decompression of congenital diaphragmatic hernia – preliminary results of a fetal sheep model

2014 ◽  
Author(s):  
Felipe Fromm ◽  
Katharina Wenke ◽  
Thomas Krebs ◽  
Michael Boettcher ◽  
Georg Eschenburg ◽  
...  
Keyword(s):  
Animal Model ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Fetal Surgery ◽  
Amniotic Cavity ◽  
Sheep Model ◽  
Fetal Sheep ◽  
Tracheal Occlusion ◽  
Animal Trials ◽  
Abdominal Decompression

Background Severe congenital diaphragmatic hernia (CDH) is prenatally managed by fetoscopic tracheal occlusion (FETO) to improve lung growth and maturation. As FETO is not able to reduce the pressure onto the developing lungs originating from the intestine growing into the thoracic cavity, fetal abdominal decompression may alleviate this pressure effect by directing the growing intestine into the amniotic cavity away from the lungs. Therefore, aim of this study was to establish an animal model for fetoscopic abdominal decompression in fetal sheep with CDH. Methods CDH was created surgically on day 75 of 145 day gestation in eight fetuses. 2-3 weeks later, an opening was created in the fetal abdomen by fetoscopic surgery. The fetuses were retrieved by cesarean section at the end of pregnancy and evaluated. Results Five fetuses with CDH were treated with fetoscopic abdominal decompression. Three fetuses with CDH were taken as controls. One fetus was lost after creation of the CDH and two other after creation of the abdominal defect. Preliminary sterological results showed that the septal thickness of the experimental group was smaller than in the CDH group. Conclusion This study demonstrates the general feasibility of fetoscopic abdominal decompression for diaphragmatic hernia in our new animal model. Although not statistically significant, the lungs of treated fetuses were larger and heavier than those of untreated controls. Our findings support the hypothesis of palliative fetal surgery for severe CDH compared to tracheal occlusion. More controlled animal trials are needed.

Impact of Congenital Diaphragmatic Hernia on Lung Development: Parenchymal and Vascular Changes in an Ovine Model

2002 ◽  
Vol 103 (s47) ◽  
pp. 53P-53P
Author(s):  
SM Nelson ◽  
CA Hajivassiliou ◽  
AD Cameron ◽  
G Haddock ◽  
P Dunkley ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Lung Development ◽  
Vascular Changes ◽  
Ovine Model

Congenital diaphragmatic hernia: Impact of preoperative stabilization. A prospective pilot study in 13 patients

1988 ◽  
Vol 23 (12) ◽  
pp. 1139-1146 ◽  
Author(s):  
Frans W.J. Hazebroek ◽  
Dick Tibboel ◽  
Albert P. Bos ◽  
Annemieke W. Pattenier ◽  
Gerard C. Madern ◽  
...  
Keyword(s):  
Pilot Study ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Prospective Pilot Study

Phospholipid Profile of Amniotic Fluid in Ovine Model of Congenital Diaphragmatic Hernia (CDH): The Effect of Fetal Tracheal Occlusion

2015 ◽  
Vol 14 (3) ◽  
pp. 1465-1471 ◽  
Author(s):  
Maria Chiara Mimmi ◽  
Maurizio Ballico ◽  
Francesco Amoroso ◽  
Valeria Calcaterra ◽  
Mario Marotta ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model ◽  
Tracheal Occlusion ◽  
Phospholipid Profile

scholarly journals BMP4 and LGL1 are Down Regulated in an Ovine Model of Congenital Diaphragmatic Hernia

2014 ◽  
Vol 1 ◽  
Author(s):  
Heather M. A. Emmerton-Coughlin ◽  
K. Kathryn Martin ◽  
Jacky S. S. Chiu ◽  
Lin Zhao ◽  
Leslie A. Scott ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model

An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling

2020 ◽  
Vol 40 (6) ◽  
pp. 952-961
Author(s):  
Fiammetta Piersigilli ◽  
Mansoor Syed ◽  
TuKiet T. Lam ◽  
Andrea Dotta ◽  
Michela Massoud ◽  
...  
Keyword(s):  
Pilot Study ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Metabolomic Profiling
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