scholarly journals The immunopathogenesis of oral lichen planus—Is there a role for mucosal associated invariant T cells?

2019 ◽  
Vol 48 (7) ◽  
pp. 552-559 ◽  
Author(s):  
Lara M. DeAngelis ◽  
Nicola Cirillo ◽  
Michael J. McCullough
Keyword(s):  
T Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Invariant T Cells ◽  
Oral Lichen

Regulatory T-cells and IL17A+ cells infiltrate oral lichen planus lesions

Pathology ◽  
2016 ◽  
Vol 48 (6) ◽  
pp. 564-573 ◽  
Author(s):  
L.R. Javvadi ◽  
V.P.B. Parachuru ◽  
T.J. Milne ◽  
G.J. Seymour ◽  
A.M. Rich
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ya-Qin Tan ◽  
Jing Zhang ◽  
Ge-Fei Du ◽  
Rui Lu ◽  
Guan-Ying Chen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Lichen Planus ◽  
Clinical Features ◽  
Peripheral Blood ◽  
Oral Lichen Planus ◽  
T Cell Response ◽  
Mrna Levels ◽  
Inflammatory Autoimmune Disease ◽  
Oral Lichen

Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed thatIGF1expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition,ATG9BmRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression ofHGS,ESR1, andSNCAbetween OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.

Intra-epithelial CD8+ T cells and basement membrane disruption in oral lichen planus

2002 ◽  
Vol 31 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Xijing J. Zhou ◽  
Philip B. Sugerman ◽  
Neil W. Savage ◽  
Laurence J. Walsh ◽  
Gregory J. Seymour
Keyword(s):  
T Cells ◽  
Basement Membrane ◽  
Lichen Planus ◽  
Cd8 T Cells ◽  
Oral Lichen Planus ◽  
Membrane Disruption ◽  
Oral Lichen

Accumulation of oligoclonal T cells in the infiltrating lymphocytes in oral lichen planus

2003 ◽  
Vol 32 (5) ◽  
pp. 282-289 ◽  
Author(s):  
E. Kawamura ◽  
S. Nakamura ◽  
M. Sasaki ◽  
Y. Ohyama ◽  
T. Kadena ◽  
...  
Keyword(s):  
T Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Infiltrating Lymphocytes ◽  
Oral Lichen
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