scholarly journals Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ya-Qin Tan ◽  
Jing Zhang ◽  
Ge-Fei Du ◽  
Rui Lu ◽  
Guan-Ying Chen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Lichen Planus ◽  
Clinical Features ◽  
Peripheral Blood ◽  
Oral Lichen Planus ◽  
T Cell Response ◽  
Mrna Levels ◽  
Inflammatory Autoimmune Disease ◽  
Oral Lichen

Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed thatIGF1expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition,ATG9BmRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression ofHGS,ESR1, andSNCAbetween OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.

Different Expression of MicroRNA-146a in Peripheral Blood CD4+ T Cells and Lesions of Oral Lichen Planus

Inflammation ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. 860-866 ◽  
Author(s):  
Jian-Guang Yang ◽  
Ya-Ru Sun ◽  
Guan-Ying Chen ◽  
Xue-Yi Liang ◽  
Jing Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Lichen Planus ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Oral Lichen Planus ◽  
Oral Lichen

Increased B7-H1 Expression on Peripheral Blood T Cells in Oral Lichen Planus Correlated with Disease Severity

2012 ◽  
Vol 32 (4) ◽  
pp. 794-801 ◽  
Author(s):  
Gang Zhou ◽  
Jing Zhang ◽  
Xiang-wei Ren ◽  
Jing-yu Hu ◽  
Ge-fei Du ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Severity ◽  
Lichen Planus ◽  
Peripheral Blood ◽  
Oral Lichen Planus ◽  
Oral Lichen

Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus

Cytokine ◽  
2013 ◽  
Vol 62 (1) ◽  
pp. 141-145 ◽  
Author(s):  
Jing-Yu Hu ◽  
Jing Zhang ◽  
Ji-Li Cui ◽  
Xue-Yi Liang ◽  
Rui Lu ◽  
...  
Keyword(s):  
T Cells ◽  
Lichen Planus ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Oral Lichen Planus ◽  
Oral Lichen

Number V Oral lichen planus: clinical features and management

Oral Diseases ◽  
2005 ◽  
Vol 11 (6) ◽  
pp. 338-349 ◽  
Author(s):  
D Eisen ◽  
M Carrozzo ◽  
J-V Bagan Sebastian ◽  
K Thongprasom
Keyword(s):  
Lichen Planus ◽  
Clinical Features ◽  
Oral Lichen Planus ◽  
Oral Lichen

A patient with drug-induced oral lichen planus who had autoantibody in peripheral blood

2009 ◽  
Vol 38 (5) ◽  
pp. 568
Author(s):  
A. Kumagai ◽  
S. Matsuo ◽  
H. Furuuchi ◽  
H. Hoshi ◽  
Y. Sugiyama
Keyword(s):  
Lichen Planus ◽  
Peripheral Blood ◽  
Oral Lichen Planus ◽  
Drug Induced ◽  
Oral Lichen

scholarly journals The Transcriptional Differences of Avian CD4+CD8+ Double-Positive T Cells and CD8+ T Cells From Peripheral Blood of ALV-J Infected Chickens Revealed by Smart-Seq2

2021 ◽  
Vol 11 ◽  
Author(s):  
Manman Dai ◽  
Li Zhao ◽  
Ziwei Li ◽  
Xiaobo Li ◽  
Bowen You ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Signaling Pathway ◽  
Cell Population ◽  
Peripheral Blood ◽  
T Cell Response ◽  
T Cell Subsets ◽  
High Expression ◽  
Receptor Interaction ◽  
Double Positive

It is well known that chicken CD8+ T cell response is vital to clearing viral infections. However, the differences between T cell subsets expressing CD8 receptors in chicken peripheral blood mononuclear cells (PBMCs) have not been compared. Herein, we used Smart-Seq2 scRNA-seq technology to characterize the difference of chicken CD8high+, CD8high αα+, CD8high αβ+, CD8medium+, and CD4+CD8low+ T cell subsets from PBMCs of avian leukosis virus subgroup J (ALV-J)-infected chickens. Weighted gene co-expression network analysis (WGCNA) and Trend analysis revealed that genes enriched in the “Cytokine–cytokine receptor interaction” pathway were most highly expressed in the CD8high αα+ T cell population, especially T cell activation or response-related genes including CD40LG, IL2RA, IL2RB, IL17A, IL1R1, TNFRSF25, and TNFRSF11, suggesting that CD8high αα+ T cells rather than other CD8 subpopulations were more responsive to ALV-J infections. On the other hand, genes involved in the “FoxO signaling pathway” and “TGF-beta signaling pathway” were most highly expressed in the CD4+CD8low+ (CD8low+) T cell population and the function of CD4+CD8low+ T cells may play roles in negatively regulating the functions of T cells based on the high expression of CCND1, ROCK1, FOXO1, FOXO3, TNFRSF18, and TNFRSF21. The selected gene expressions in CD8+ T cells and CD4+CD8low+ double-positive T cells confirmed by qRT-PCR matched the Smart-Seq2 data, indicating the reliability of the smart-seq results. The high expressions of Granzyme K, Granzyme A, and CCL5 indicated the positive response of CD8+ T cells. Conversely, CD4+CD8+ T cells may have the suppressor activity based on the low expression of activation molecules but high expression of T cell activity suppressor genes. These findings verified the heterogeneity and transcriptional differences of T cells expressing CD8 receptors in chicken PBMCs.

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