scholarly journals A loss of profilin-1 in late-stage oral squamous cell carcinoma

2016 ◽  
Vol 46 (7) ◽  
pp. 489-495 ◽  
Author(s):  
Guy R. Adami ◽  
Thomas N. O'Callaghan ◽  
Antonia Kolokythas ◽  
Robert. J. Cabay ◽  
Yalu Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage

scholarly journals Serum Levels of OX40 in Early and Late-Stage Oral Squamous Cell Carcinoma

Cureus ◽  
2021 ◽  
Author(s):  
Aliya I Sani ◽  
Zil E Rubab ◽  
Shumaila Usman ◽  
Syed Zaryab Ahmed ◽  
Mervyn Hosein ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage ◽  
Serum Levels

scholarly journals Assessment of The Association of OCT3/4 With GLUT1 And CD105 In Oral Squamous Cell Carcinoma Using Dual Immunohistochemistry

2022 ◽  
Author(s):  
Samira Derakhshan ◽  
Nazanin Mahdavi ◽  
Neda Kardouni Khoozestani ◽  
Bita Nasr Esfahani ◽  
Forouzan Heidarian ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage ◽  
Cancer Type ◽  
Hypoxic Response ◽  
Glucose Transporter 1

Abstract Background: Oral squamous cell carcinoma (OSCC) is the most common cancer type affecting the oral and maxillofacial region. This study aimed to investigate the role of cancer stem cells (CSCs) in angiogenesis and hypoxic response in OSCC.Methods: This retrospective observational study evaluated 56 cases of OSCC using dual immunohistochemistry. Octamer-binding transcription factor 3/4 (OCT3/4) marker was used for evaluation of CSC activity. Glucose transporter 1 (GLUT1) marker was used to evaluate the hypoxic response and angiogenesis, while endoglin (CD105) was used to evaluate the late stage of angiogenesis and blood vessel formation.Results: Overexpression of both OCT3/4 and GLUT1 was noted in early stage of hypoxic response and angiogenesis in OSCC, indicating the important role of CSCs in this phase. However, despite higher expression of CD105, the expression of CSC markers was not significant in the late stage of tumor progression and angiogenesis.Conclusions: CSCs could play important roles in initial stages of tumor progression and angiogenesis. Further studies are required to discover other biomarkers, their roles, and associated pathways of CSCs in OSCC.

scholarly journals Correlation between Sociodemograpic Charecteristics and Clinicopathological Presentation of Oral Squamous Cell Carcinoma: A Crossectional Study from a Tertiary Care Cancer Centre, Odisha.

2021 ◽  
Vol 8 (11) ◽  
pp. 5746-5752
Author(s):  
Paresh Kumar Behera ◽  
Sasmita Panda ◽  
Subrat Kumar Samanatar ◽  
Sashibhusan Dash
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Early Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage ◽  
Public Awareness ◽  
Tertiary Care ◽  
Sociodemographic Characteristics ◽  
Diabetes Diagnosis

Background: Oral squamous cell carcinoma (OSCC) is significantly higher in India as about 70% of the cases are reported in the advanced stages leaving five-year survival rates around 20% only. Primary prevention and early diagnosis were found to be novel approaches to avert cancer cases and related deaths. In India, organized prevention and early detection efforts are still lacking. Aim and objectives: To investigate the correlation between sociodemographic characteristics and clinicopathological presentation of oral squamous cell carcinoma. Materials and methods: Single hospital-based crossectional retrospective study was carried out at the Department of Head and Neck Oncology, Acharya Harihar Post Graduate Institute of Cancer, Cuttack for a period of three years from October 2018 to September 2021. Results: A total of 418 cases of histopathologically confirmed OSCC were reported during this study period.  There were 314 (75.11%) male and 104 (24.88%) female patients. The mean (± SD) age of the patients was 52.29 ± 13.37 years with ranging from 21 to 89 years. When checked for the association between tumor stage (early stage I/II and late-stage III and IV) and sociodemographic characteristics,we found middle age male,rural residency,low soccioeconomic status,illiteracy, chewing gutkha  7-10 numbers per day more than 10 years, were significantly associated with the late-stage tumors. Similarly, tumor at left buccal mucosa and border of tongue, moderately and poorly differentiated tumor, underlying Type 2 diabetes, diagnosis more than 10 months after the onset of symptoms were significantly associated with late stage presentation. Conclusion: There is an important need to initiate public awareness programs in our region to control and prevent oral cancer by screening for early diagnosis and supporting a tobacco-free environment.

scholarly journals Identification of potential salivary biomarker panels for oral squamous cell carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anu Jain ◽  
Chinmaya Narayana Kotimoole ◽  
Sushmita Ghoshal ◽  
Jaimanti Bakshi ◽  
Aditi Chatterjee ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Sensitivity And Specificity ◽  
Squamous Cell ◽  
Roc Curve ◽  
Late Stage ◽  
Significant Risk ◽  
Late Presentation ◽  
Salivary Proteins

AbstractOral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide with the maximum number of incidences and deaths reported from India. One of the major causes of poor survival rate associated with OSCC has been attributed to late presentation due to non-availability of a biomarker. Identification of early diagnostic biomarker will help in reducing the disease morbidity and mortality. We validated 12 salivary proteins using targeted proteomics, identified initially by relative quantification of salivary proteins on LC–MS, in OSCC patients and controls. Salivary AHSG (p = 0.0041**) and KRT6C (p = 0.002**) were upregulated in OSCC cases and AZGP1 (p ≤ 0.0001***), KLK1 (p = 0.006**) and BPIFB2 (p = 0.0061**) were downregulated. Regression modelling resulted in a significant risk prediction model (p < 0.0001***) consisting of AZGP1, AHSG and KRT6C for which ROC curve had AUC, sensitivity and specificity of 82.4%, 78% and 73.5% respectively for all OSCC cases and 87.9%, 87.5% and 73.5% respectively for late stage (T3/T4) OSCC. AZGP1, AHSG, KRT6C and BPIFB2 together resulted in ROC curve (p < 0.0001***) with AUC, sensitivity and specificity of 94%, 100% and 77.6% respectively for N0 cases while KRT6C and AZGP1 for N+ cases with ROC curve (p < 0.0001***) having AUC sensitivity and specificity of 76.8%, 73% and 69.4%. Our data aids in the identification of biomarker panels for the diagnosis of OSCC cases with a differential diagnosis between early and late-stage cases.

Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma

2019 ◽  
Vol 98 (5) ◽  
pp. 517-525 ◽  
Author(s):  
T. Saito ◽  
K. Uzawa ◽  
M. Terajima ◽  
M. Shiiba ◽  
A.L. Amelio ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage ◽  
Cross Linking ◽  
Key Enzymes ◽  
Cross Links ◽  
Collagen Cross Linking

Tumor progression is a complex process involving extracellular matrix (ECM) remodeling and stiffening. However, the mechanisms that govern these processes and their roles in tumor progression are still poorly understood. In this study, we performed bioinformatics, immunohistochemical, and biochemical analyses to examine if collagen cross-linking is associated with tumor stage and regional lymph node metastasis (RLNM) in oral squamous cell carcinoma (OSCC). We found that the genes encoding key enzymes for cross-linking are frequently overexpressed in oral, head, and neck cancers. Specifically, the enzymes lysyl hydroxylase 2 (LH2) or lysyl oxidase (LOX) and LOX-like 2 (LOXL2) were significantly upregulated in late-stage tumors and associated with poor patient prognosis. The protein levels of these enzymes in the primary human OSCC were also significantly increased in late-stage tumors and markedly elevated in the RLNM-positive tumors. Notably, while overall LOX/LOXL2-catalyzed collagen cross-links were enriched in late-stage and RLNM-positive tumors, LH2-mediated stable cross-links were significantly increased. To our knowledge, this is the first study to investigate the association of collagen cross-linking and expression of key enzymes regulating this process with OSCC stage. The data indicate a critical role for collagen cross-linking in OSCC tumor progression and metastasis, which may provide insights into development of novel therapeutic strategies to prevent OSCC progression.

CPA6, FMO2, LGI1, SIAT1 and TNC are differentially expressed in early- and late-stage oral squamous cell carcinoma – A pilot study

Oral Oncology ◽  
2008 ◽  
Vol 44 (10) ◽  
pp. 941-948 ◽  
Author(s):  
Florian Fialka ◽  
Rudolf Matthias Gruber ◽  
Reiner Hitt ◽  
Lennart Opitz ◽  
Edgar Brunner ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage ◽  
Differentially Expressed

scholarly journals PTENallelic loss is an important mechanism in the late stage of development of oral leucoplakia into oral squamous cell carcinoma

2017 ◽  
Vol 72 (2) ◽  
pp. 330-338 ◽  
Author(s):  
Ligia A N Miyahara ◽  
Flávia S C Pontes ◽  
Rommel M R Burbano ◽  
Nicolau Conte Neto ◽  
Douglas M Guimarães ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage ◽  
Stage Of Development

scholarly journals Factors related to late stage diagnosis of oral squamous cell carcinoma

2012 ◽  
pp. e35-e40 ◽  
Author(s):  
JM. Seoane-Romero ◽  
I. Vazquez-Mahia ◽  
J. Seoane ◽  
P. Varela-Centelles ◽  
I. Tomas ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Late Stage ◽  
Late Stage Diagnosis
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