Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions

2015 ◽  
Vol 45 (4) ◽  
pp. 281-288 ◽  
Author(s):  
Şule Batu ◽  
Duygu Ofluoğlu ◽  
Sertan Ergun ◽  
Saman Warnakulasuriya ◽  
Ezel Uslu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Prolidase Activity ◽  
Oral Lichen ◽  
And Oxidative Stress

scholarly journals Evaluation of Uric Acid, Total Antioxidant and Lipid Peroxidation Parameters in Serum and Saliva of Patients with Oral Lichen Planus

2016 ◽  
Vol 8 (12) ◽  
pp. 225 ◽  
Author(s):  
Atena Shiva ◽  
Shahin Arab
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Control Group ◽  
Healthy Controls ◽  
Total Antioxidant ◽  
Healthy Control ◽  
Oral Lichen ◽  
And Oxidative Stress

<p><strong>BACKGROUND</strong><strong>: </strong>Oral lichen planus (OLP) is a chronic and inflammation mucosal disease. Reactive Oxygen Species (ROS) and oxidative stress damage might be the cause. Malondialdehyd (MDA), one parameter of lipid peroxidation is appropriate for DNA damage in OLP disease.</p><p><strong>OBJECTIVE</strong><strong>: </strong>To evaluate antioxidants and oxidative stress parameters in patients with oral lichen planus (OLP) diseases and healthy control group with compare on serum and salivary samples.</p><p><strong>MATERIAL </strong><strong>&amp;</strong><strong> METHODS: </strong>The research population included 22 patients with OLP which recently diagnosed and 22 healthy controls matched for periodontal status. Total antioxidant activity (TAA), Malondialdehyde (MDA) or lipid peroxidation product and uric acid (UA) were evaluated in both serum and saliva. The t-tests were used for differences between the two groups in normal distributed variables and also Spearman’s rho correlation coefficient for assessing association between serum and salivary fluids.</p><p><strong>RESULTS</strong><strong>: </strong>TAA levels in OLP patients showed significant result and lower than healthy control group (p=0.39). Also, results in the saliva MDA concentration, was significantly higher in OLP patients than controls. In correlation test, inverse and significant correlation was observed between the MDA and UA values(r=0. 682, P=0.0001) and a significant correlation was found between serum TAA and UA values.</p><p><strong>CONCLUSION</strong><strong>: </strong>This study showed that OLP groups have higher cellular lipid peroxidation in compare to healthy controls and low level of TAA than controls. Patients with OLP are believed to be more at risk of antioxidant-oxidative stress imbalance.</p>

Oxidative stress markers in oral lichen planus

BioFactors ◽  
2008 ◽  
Vol 33 (4) ◽  
pp. 301-310 ◽  
Author(s):  
M. Battino ◽  
M. Greabu ◽  
A. Totan ◽  
M. Mohora ◽  
P. Bullon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Oral Lichen

Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus

2010 ◽  
Vol 40 (4) ◽  
pp. 286-293 ◽  
Author(s):  
Sertan Ergun ◽  
Şule Can Troşala ◽  
Saman Warnakulasuriya ◽  
Sevda Özel ◽  
Ayşe Emel Önal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Antioxidant Profile ◽  
Oral Lichen

scholarly journals Systematic Review and Meta-Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Jia Wang ◽  
Jingjing Yang ◽  
Chen Wang ◽  
Zhibai Zhao ◽  
Yuan Fan
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Chronic Inflammatory Disease ◽  
Cochrane Library ◽  
Unknown Etiology ◽  
Antioxidant Systems ◽  
Antioxidant Markers ◽  
Oral Lichen

Background. Oral lichen planus (OLP) is a relatively common chronic inflammatory disease of unknown etiology, which might be caused by oxidative stress and impaired antioxidant defense. Objective. To systematically investigate the markers of oxidative stress and antioxidant systems in the saliva and blood from OLP patients and healthy controls. Methods. The PubMed, Cochrane Library, and Embase were systematically queried to collect data from studies in which oxidative stress/antioxidant markers from OLP and healthy subjects had been evaluated until March 10, 2021. Results. A total of 28 studies fulfilled inclusion criteria, and 25 of them, having 849 OLP patients and 1,052 control subjects and analyzing 12 oxidative stress and antioxidant state marker levels, were subjected to meta-analysis. We found a significant decrease in total antioxidant capacity (TAC) and uric acid (UA) and a significant increase in malondialdehyde (MDA) and nitric oxide (NO) levels in the saliva and serum/plasma of OLP patients. Moreover, a significant elevation of 8-hydroxy-deoxyguanosine (8-OHdG) and advanced oxidation protein product (AOOP) level and a decrease in vitamin C were also observed in the saliva of the OLP group. In contrast, salivary vitamin A, zinc, glutathione peroxidase (GPx), vitamin E, and nitrite were not significantly different between the two groups. In single studies, markers of oxidative stresses such as superoxide dismutase (SOD) and 8-isoprostanelevels were elevated in OLP, and antioxidant parameters such as glutathione (GSH) and total protein (TP) levels were dysregulated. Conclusion. This meta-analysis helps to clarify the profile of oxidative stress and antioxidant state markers in OLP patients although existing evidence is rather heterogeneous and many studies are affected by several limitations. Larger and more standardized studies are warranted to ascertain whether these markers are potential causes or effects of OLP and whether antioxidant therapy improving oxidative stress will be useful.

Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment

2015 ◽  
Vol 45 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Seyed Isaac Hashemy ◽  
Shideh Gharaei ◽  
Samaneh Vasigh ◽  
Sanaz Kargozar ◽  
Banafsheh Alirezaei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Stress Factors ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Oral Lichen
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