Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment

2015 ◽  
Vol 45 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Seyed Isaac Hashemy ◽  
Shideh Gharaei ◽  
Samaneh Vasigh ◽  
Sanaz Kargozar ◽  
Banafsheh Alirezaei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Stress Factors ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Oral Lichen

scholarly journals Evaluation of Salivary C-Reactive Protein and Psychological Factors in Patients with Oral Lichen Planus: A Cross-sectional Study

2021 ◽  
Author(s):  
Shruti Anand Patil ◽  
Amita Aditya ◽  
Daya K Jangam
Keyword(s):  
Lichen Planus ◽  
Psychological Factors ◽  
Oral Lichen Planus ◽  
Cross Sectional Study ◽  
Psychological Status ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Oral Lichen

Introduction: Aetiology and pathogenesis of Oral Lichen Planus (OLP) has been focus of research since a long time and various aetiological factors like autoimmunity, heredity, drugs, dental materials, psychological factors, especially stress and anxiety have been reported to be associated with this disease. Few studies in past have found significant elevations in C-Reactive Protein (CRP) levels in individuals who reported to be having chronic stress. Both altered salivary CRP levels and psychological stress have been reported in OLP patients. To the best of our knowledge no such studies have been conducted in past, so a need was felt to conduct a study to evaluate and also correlate salivary CRP and psychological factors in OLP patients. Aim: To evaluate salivary CRP and psychological factors and assess only possible correlation between them in patients with OLP. Materials and Methods: This cross-sectional study included of two groups: Group A- consisting of 33 individuals clinically diagnosed with OLP and Group B- consisting of 33, age and gender matched healthy individuals. Hospital Anxiety and Depression Scale (HADS) was used for all the participants to evaluate the psychological factors. Salivary CRP levels were evaluated using Mispa i2 Nephelometry. Statistical analysis was done using SPSS software. Results: Mean salivary CRP value among cases was 3.42±2.786 and among controls was 2.84±.848. Mean HADS score among cases was 6.60±2.796 and among controls was 2.70±.948. Mean Salivary CRP and HADS values were higher in OLP patients compared to controls. However, no statistical significant association could be established between CRP and HADS in patients with OLP (p=0.200). Conclusion: No correlation between psychological status and CRP levels could be established in patients with OLP. CRP couldbe used as a diagnostic marker in oral premalignantlesions.

scholarly journals Salivary Lactate Dehydrogenase, C-Reactive Protein, and Cancer Antigen 125 Levels in Patients with Oral Lichen Planus and Oral Squamous Cell Carcinoma

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Marieh Honarmand ◽  
Ramin Saravani ◽  
Leila Farhad-Mollashahi ◽  
Amin Smailpoor
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lactate Dehydrogenase ◽  
Oral Lichen Planus ◽  
Control Group ◽  
C Reactive Protein ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Reactive Protein ◽  
Oral Lichen ◽  
Healthy Persons

Background: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and oral lichen planus (OLP) is considered a premalignant disease. Objectives: This study aims at comparing the salivary levels of lactate dehydrogenase (LDH), C-reactive protein (CRP), and cancer antigen 125 (CA125) among cases with OSCC, OLP, and healthy persons. Methods: In this case-control study, salivary markers were evaluated in 55 cases (15 patients with OSCC, 20 patients with OLP, and 20 healthy persons); non-stimulated saliva samples were collected from the patients and saliva markers were measured by the enzyme-linked immunosorbent assay (ELISA) method. The data were analyzed, using SPSS 21 software and ANOVA test and P < 0.05 was regarded as significant. Results: Salivary LDH and CA125 levels were significantly higher in OSCC and OLP patients compared to the control group (P < 0.05). Salivary CRP levels were significantly higher in OSCC patients compared to OLP patients (P < 0.05). Besides, salivary CRP levels were higher in OLP subjects than in the control group, but the difference was not significant (P = 0.56). Conclusions: The identification of the salivary LDH, CA125, and CRP may provide a suitable non-invasive predictive tool for malignant changes. However, its use in clinical practice needs further research.

Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions

2015 ◽  
Vol 45 (4) ◽  
pp. 281-288 ◽  
Author(s):  
Şule Batu ◽  
Duygu Ofluoğlu ◽  
Sertan Ergun ◽  
Saman Warnakulasuriya ◽  
Ezel Uslu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Prolidase Activity ◽  
Oral Lichen ◽  
And Oxidative Stress

Oxidative stress markers in oral lichen planus

BioFactors ◽  
2008 ◽  
Vol 33 (4) ◽  
pp. 301-310 ◽  
Author(s):  
M. Battino ◽  
M. Greabu ◽  
A. Totan ◽  
M. Mohora ◽  
P. Bullon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Oral Lichen

scholarly journals Evaluation of Uric Acid, Total Antioxidant and Lipid Peroxidation Parameters in Serum and Saliva of Patients with Oral Lichen Planus

2016 ◽  
Vol 8 (12) ◽  
pp. 225 ◽  
Author(s):  
Atena Shiva ◽  
Shahin Arab
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Control Group ◽  
Healthy Controls ◽  
Total Antioxidant ◽  
Healthy Control ◽  
Oral Lichen ◽  
And Oxidative Stress

<p><strong>BACKGROUND</strong><strong>: </strong>Oral lichen planus (OLP) is a chronic and inflammation mucosal disease. Reactive Oxygen Species (ROS) and oxidative stress damage might be the cause. Malondialdehyd (MDA), one parameter of lipid peroxidation is appropriate for DNA damage in OLP disease.</p><p><strong>OBJECTIVE</strong><strong>: </strong>To evaluate antioxidants and oxidative stress parameters in patients with oral lichen planus (OLP) diseases and healthy control group with compare on serum and salivary samples.</p><p><strong>MATERIAL </strong><strong>&amp;</strong><strong> METHODS: </strong>The research population included 22 patients with OLP which recently diagnosed and 22 healthy controls matched for periodontal status. Total antioxidant activity (TAA), Malondialdehyde (MDA) or lipid peroxidation product and uric acid (UA) were evaluated in both serum and saliva. The t-tests were used for differences between the two groups in normal distributed variables and also Spearman’s rho correlation coefficient for assessing association between serum and salivary fluids.</p><p><strong>RESULTS</strong><strong>: </strong>TAA levels in OLP patients showed significant result and lower than healthy control group (p=0.39). Also, results in the saliva MDA concentration, was significantly higher in OLP patients than controls. In correlation test, inverse and significant correlation was observed between the MDA and UA values(r=0. 682, P=0.0001) and a significant correlation was found between serum TAA and UA values.</p><p><strong>CONCLUSION</strong><strong>: </strong>This study showed that OLP groups have higher cellular lipid peroxidation in compare to healthy controls and low level of TAA than controls. Patients with OLP are believed to be more at risk of antioxidant-oxidative stress imbalance.</p>

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