Water content changes in new multiple sclerosis lesions have a minimal effect on the determination of myelin water fraction values

2021 ◽  
Author(s):  
Irene M. Vavasour ◽  
Kimberley L. Chang ◽  
Anna J. E. Combes ◽  
Sandra M. Meyers ◽  
Shannon H. Kolind ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Content ◽  
Minimal Effect ◽  
Water Fraction ◽  
Myelin Water Fraction

Water content and myelin water fraction in multiple sclerosis

2004 ◽  
Vol 251 (3) ◽  
pp. 284-293 ◽  
Author(s):  
C. Laule ◽  
I. M. Vavasour ◽  
G. R. W. Moore ◽  
J. Oger ◽  
D. K. B. Li ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Content ◽  
Water Fraction ◽  
Myelin Water Fraction

scholarly journals Myelin status is associated with change in functional mobility following slope walking in people with multiple sclerosis

2018 ◽  
Vol 4 (2) ◽  
pp. 205521731877354 ◽  
Author(s):  
EM King ◽  
MJ Sabatier ◽  
M Hoque ◽  
TM Kesar ◽  
D Backus ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Content ◽  
Therapeutic Response ◽  
Functional Mobility ◽  
Functional Impairments ◽  
Timed Up And Go ◽  
Water Fraction ◽  
Walking Intervention ◽  
Myelin Water Fraction ◽  
Multiple Sclerosis Patients

Background The level of myelin disruption in multiple sclerosis patients may impact the capacity for training-induced neuroplasticity and the magnitude of therapeutic response to rehabilitation interventions. Downslope walking has been shown to increase functional mobility in individuals with multiple sclerosis, but it is unclear if myelin status influences therapeutic response. Objective The current study aimed to examine the relationship between baseline myelin status and change in functional mobility after a walking intervention. Methods The Timed Up and Go test was used to measure functional mobility before and after completion of a repeated, six-session slope walking intervention in 16 participants with relapsing–remitting multiple sclerosis. Multi-component T2 relaxation imaging was used to index myelin water fraction of overall water content in brain tissue compartments. Results Results demonstrated that the ratio of the myelin water fraction in lesion to normal-appearing white matter (myelin water fraction ratio) significantly predicted 31% of the variance in change in Timed Up and Go score after the downslope walking intervention, where less myelin disruption was associated with greater intervention response. Conclusions Myelin water content fraction ratio may offer a neural biomarker of myelin to identify potential responders to interventions targeting functional impairments in multiple sclerosis.

Normal-appearing White Matter in Patients with Phenylketonuria: Water Content, Myelin Water Fraction, and Metabolite Concentrations

Radiology ◽  
2007 ◽  
Vol 242 (1) ◽  
pp. 236-243 ◽  
Author(s):  
Sandra M. Sirrs ◽  
Cornelia Laule ◽  
Burkhard Mädler ◽  
Elana E. Brief ◽  
Sumia A. Tahir ◽  
...  
Keyword(s):  
White Matter ◽  
Water Content ◽  
Water Fraction ◽  
Normal Appearing White Matter ◽  
Metabolite Concentrations ◽  
Myelin Water Fraction

scholarly journals Impact of Lesion Location on Longitudinal Myelin Water Fraction Change in Chronic Multiple Sclerosis Lesions

2020 ◽  
Vol 30 (4) ◽  
pp. 537-543
Author(s):  
Sneha Pandya ◽  
Ulrike W Kaunzner ◽  
Sandra M Hurtado Rúa ◽  
Nancy Nealon ◽  
Jai Perumal ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Fraction ◽  
Lesion Location ◽  
Myelin Water Fraction

scholarly journals Measuring longitudinal myelin water fraction in new multiple sclerosis lesions

2015 ◽  
Vol 9 ◽  
pp. 369-375 ◽  
Author(s):  
Wendy S. Vargas ◽  
Elizabeth Monohan ◽  
Sneha Pandya ◽  
Ashish Raj ◽  
Timothy Vartanian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Fraction ◽  
Myelin Water Fraction

Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder

2016 ◽  
Vol 22 (12) ◽  
pp. 1616-1620 ◽  
Author(s):  
In Hye Jeong ◽  
Joon Yul Choi ◽  
Su-Hyun Kim ◽  
Jae-Won Hyun ◽  
AeRan Joung ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Neuromyelitis Optica ◽  
White Matter Lesions ◽  
Spectrum Disorder ◽  
Periventricular White Matter ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Water Fraction ◽  
Myelin Water Fraction ◽  
The Central Nervous System

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.

Corticospinal tract integrity measured using transcranial magnetic stimulation and magnetic resonance imaging in neuromyelitis optica and multiple sclerosis

2015 ◽  
Vol 22 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Praveena Manogaran ◽  
Irene Vavasour ◽  
Michael Borich ◽  
Shannon H Kolind ◽  
Alex P Lange ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Resonance ◽  
Magnetic Stimulation ◽  
Corticospinal Tract ◽  
Resonance Imaging ◽  
Recruitment Curve ◽  
Water Fraction ◽  
Myelin Water Fraction

Background: Both multiple sclerosis (MS) and neuromyelitis optica (NMO) can present with transverse myelitis; however, NMO symptoms are usually more severe and may present with more extensive axonal loss. Transcranial magnetic stimulation (TMS)-based input–output recruitment curves can quantitatively assess the excitability of corticospinal tract pathways and myelin water imaging can quantify the amount of myelin within this same pathway. Objective: To compare differential effects of MS and NMO on TMS recruitment curves and myelin water imaging. Methods: Ten healthy controls, 10 individuals with MS and 10 individuals with NMO completed clinical assessments, a TMS assessment and magnetic resonance imaging scan to measure recruitment curves and myelin water fraction in the corticospinal tract. Results: Individuals with NMO had lower recruitment curve slopes (mean 13.6±6 μV/%) than MS (23.6±11 μV/%) and controls (21.9±9 μV/%, analysis of variance (ANOVA) P=0.05). Corticospinal tract myelin water fraction was lower in individuals with NMO (mean 0.17±0.02) compared to MS (0.19±0.02) and controls (0.20±0.02, ANOVA P=0.0006). Conclusion: Corticospinal pathway damage in individuals with NMO was evident by reduced recruitment curve slope and lower myelin water fraction. These specific measures of corticospinal function and structure may be used to obtain a better understanding and monitor brain injury caused by inflammatory central nervous system disorders.

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