scholarly journals Impact of Lesion Location on Longitudinal Myelin Water Fraction Change in Chronic Multiple Sclerosis Lesions

2020 ◽  
Vol 30 (4) ◽  
pp. 537-543
Author(s):  
Sneha Pandya ◽  
Ulrike W Kaunzner ◽  
Sandra M Hurtado Rúa ◽  
Nancy Nealon ◽  
Jai Perumal ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Fraction ◽  
Lesion Location ◽  
Myelin Water Fraction

scholarly journals Measuring longitudinal myelin water fraction in new multiple sclerosis lesions

2015 ◽  
Vol 9 ◽  
pp. 369-375 ◽  
Author(s):  
Wendy S. Vargas ◽  
Elizabeth Monohan ◽  
Sneha Pandya ◽  
Ashish Raj ◽  
Timothy Vartanian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Fraction ◽  
Myelin Water Fraction

Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder

2016 ◽  
Vol 22 (12) ◽  
pp. 1616-1620 ◽  
Author(s):  
In Hye Jeong ◽  
Joon Yul Choi ◽  
Su-Hyun Kim ◽  
Jae-Won Hyun ◽  
AeRan Joung ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Neuromyelitis Optica ◽  
White Matter Lesions ◽  
Spectrum Disorder ◽  
Periventricular White Matter ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Water Fraction ◽  
Myelin Water Fraction ◽  
The Central Nervous System

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.

Corticospinal tract integrity measured using transcranial magnetic stimulation and magnetic resonance imaging in neuromyelitis optica and multiple sclerosis

2015 ◽  
Vol 22 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Praveena Manogaran ◽  
Irene Vavasour ◽  
Michael Borich ◽  
Shannon H Kolind ◽  
Alex P Lange ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Resonance ◽  
Magnetic Stimulation ◽  
Corticospinal Tract ◽  
Resonance Imaging ◽  
Recruitment Curve ◽  
Water Fraction ◽  
Myelin Water Fraction

Background: Both multiple sclerosis (MS) and neuromyelitis optica (NMO) can present with transverse myelitis; however, NMO symptoms are usually more severe and may present with more extensive axonal loss. Transcranial magnetic stimulation (TMS)-based input–output recruitment curves can quantitatively assess the excitability of corticospinal tract pathways and myelin water imaging can quantify the amount of myelin within this same pathway. Objective: To compare differential effects of MS and NMO on TMS recruitment curves and myelin water imaging. Methods: Ten healthy controls, 10 individuals with MS and 10 individuals with NMO completed clinical assessments, a TMS assessment and magnetic resonance imaging scan to measure recruitment curves and myelin water fraction in the corticospinal tract. Results: Individuals with NMO had lower recruitment curve slopes (mean 13.6±6 μV/%) than MS (23.6±11 μV/%) and controls (21.9±9 μV/%, analysis of variance (ANOVA) P=0.05). Corticospinal tract myelin water fraction was lower in individuals with NMO (mean 0.17±0.02) compared to MS (0.19±0.02) and controls (0.20±0.02, ANOVA P=0.0006). Conclusion: Corticospinal pathway damage in individuals with NMO was evident by reduced recruitment curve slope and lower myelin water fraction. These specific measures of corticospinal function and structure may be used to obtain a better understanding and monitor brain injury caused by inflammatory central nervous system disorders.

Water content and myelin water fraction in multiple sclerosis

2004 ◽  
Vol 251 (3) ◽  
pp. 284-293 ◽  
Author(s):  
C. Laule ◽  
I. M. Vavasour ◽  
G. R. W. Moore ◽  
J. Oger ◽  
D. K. B. Li ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Content ◽  
Water Fraction ◽  
Myelin Water Fraction

Water content changes in new multiple sclerosis lesions have a minimal effect on the determination of myelin water fraction values

2021 ◽  
Author(s):  
Irene M. Vavasour ◽  
Kimberley L. Chang ◽  
Anna J. E. Combes ◽  
Sandra M. Meyers ◽  
Shannon H. Kolind ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Content ◽  
Minimal Effect ◽  
Water Fraction ◽  
Myelin Water Fraction

scholarly journals Myelin status is associated with change in functional mobility following slope walking in people with multiple sclerosis

2018 ◽  
Vol 4 (2) ◽  
pp. 205521731877354 ◽  
Author(s):  
EM King ◽  
MJ Sabatier ◽  
M Hoque ◽  
TM Kesar ◽  
D Backus ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Water Content ◽  
Therapeutic Response ◽  
Functional Mobility ◽  
Functional Impairments ◽  
Timed Up And Go ◽  
Water Fraction ◽  
Walking Intervention ◽  
Myelin Water Fraction ◽  
Multiple Sclerosis Patients

Background The level of myelin disruption in multiple sclerosis patients may impact the capacity for training-induced neuroplasticity and the magnitude of therapeutic response to rehabilitation interventions. Downslope walking has been shown to increase functional mobility in individuals with multiple sclerosis, but it is unclear if myelin status influences therapeutic response. Objective The current study aimed to examine the relationship between baseline myelin status and change in functional mobility after a walking intervention. Methods The Timed Up and Go test was used to measure functional mobility before and after completion of a repeated, six-session slope walking intervention in 16 participants with relapsing–remitting multiple sclerosis. Multi-component T2 relaxation imaging was used to index myelin water fraction of overall water content in brain tissue compartments. Results Results demonstrated that the ratio of the myelin water fraction in lesion to normal-appearing white matter (myelin water fraction ratio) significantly predicted 31% of the variance in change in Timed Up and Go score after the downslope walking intervention, where less myelin disruption was associated with greater intervention response. Conclusions Myelin water content fraction ratio may offer a neural biomarker of myelin to identify potential responders to interventions targeting functional impairments in multiple sclerosis.

Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology

2006 ◽  
Vol 12 (6) ◽  
pp. 747-753 ◽  
Author(s):  
C Laule ◽  
E Leung ◽  
D KB Li ◽  
A L Traboulsee ◽  
D W Paty ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Regions Of Interest ◽  
Demyelinating Diseases ◽  
Practical Applications ◽  
Water Fraction ◽  
Myelin Water Fraction ◽  
Mean Optical Density ◽  
Formalin Fixed

Various magnetic resonance (MR) techniques are used to study the pathological evolution of demyelinating diseases, such as multiple sclerosis (MS). However, few studies have validated MR derived measurements with histopathology. Here, we determine the correlation of myelin water imaging, an MR measure of myelin content, with quantitative histopathologic measures of myelin density. The multi-component T2 distribution of water was determined from 25 formalin-fixed MS brain samples using a multi-echo T2 relaxation MR experiment. The myelin water fraction (MWF), defined as T2 signal below 30 milliseconds divided by the total signal, was determined for various regions of interest and compared to Luxol fast blue (myelin stain) mean optical density (OD) for each sample. MWF had a strong correlation with myelin stain [mean (range) R2-/0.67 (0.45+ 0.92)], validating MWF as a measure of myelin density. This quantitative technique has many practical applications for the in vivo monitoring of demyelination and remyelination in a variety of disorders of myelin.

scholarly journals Myelin and axon pathology in multiple sclerosis assessed by myelin water and multi-shell diffusion imaging

Brain ◽  
2021 ◽  
Author(s):  
Reza Rahmanzadeh ◽  
Po-Jui Lu ◽  
Muhamed Barakovic ◽  
Matthias Weigel ◽  
Pietro Maggi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
White Matter Lesions ◽  
Healthy Controls ◽  
Neurofilament Light Chain ◽  
Water Fraction ◽  
Neurite Density ◽  
Relapsing Remitting ◽  
Density Index ◽  
Myelin Water Fraction

Abstract Damage to the myelin sheath and the neuroaxonal unit is a cardinal feature of multiple sclerosis; however, a detailed characterization of the interaction between myelin and axon damage in vivo remains challenging. We applied myelin water and multi-shell diffusion imaging to quantify the relative damage to myelin and axons (i) among different lesion types; (ii) in normal-appearing tissue; and (iii) across multiple sclerosis clinical subtypes and healthy controls. We also assessed the relation of focal myelin/axon damage with disability and serum neurofilament light chain as a global biological measure of neuroaxonal damage. Ninety-one multiple sclerosis patients (62 relapsing-remitting, 29 progressive) and 72 healthy controls were enrolled in the study. Differences in myelin water fraction and neurite density index were substantial when lesions were compared to healthy controls and normal-appearing MS tissue: both white matter and cortical lesions exhibited a decreased myelin water fraction and neurite density index compared with healthy (P < 0.0001) and peri-plaque white matter (P < 0.0001). Periventricular lesions showed decreased myelin water fraction and neurite density index compared with lesions in the juxtacortical region (P < 0.0001 and P < 0.05). Similarly, lesions with paramagnetic rims showed decreased myelin water fraction and neurite density index relative to lesions without a rim (P < 0.0001). Also, in 75% of white matter lesions, the reduction in neurite density index was higher than the reduction in the myelin water fraction. Besides, normal-appearing white and grey matter revealed diffuse reduction of myelin water fraction and neurite density index in multiple sclerosis compared to healthy controls (P < 0.01). Further, a more extensive reduction in myelin water fraction and neurite density index in normal-appearing cortex was observed in progressive versus relapsing-remitting participants. Neurite density index in white matter lesions correlated with disability in patients with clinical deficits (P < 0.01, beta=-10.00); and neurite density index and myelin water fraction in white matter lesions were associated to serum neurofilament light chain in the entire patients cohort (P < 0.01, beta=-3.60 and P < 0.01, beta=0.13, respectively). These findings suggest that (i) myelin and axon pathology in multiple sclerosis is extensive in both lesions and normal-appearing tissue; (ii) particular types of lesions exhibit more damage to myelin and axons than others; (iii) progressive patients differ from relapsing-remitting because of more extensive axon/myelin damage in the cortex; and (iv) myelin and axon pathology in lesions is related to disability in patients with clinical deficits and global measures of neuroaxonal damage.

Sign in / Sign up

Export Citation Format

Share Document