Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis

2021 ◽  
Author(s):  
G. Pontillo ◽  
M. Petracca ◽  
S. Monti ◽  
M. Quarantelli ◽  
C. Criscuolo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

scholarly journals Whole brain and deep gray matter atrophy detection over 5 years with 3T MRI in multiple sclerosis using a variety of automated segmentation pipelines

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206939 ◽  
Author(s):  
Renxin Chu ◽  
Gloria Kim ◽  
Shahamat Tauhid ◽  
Fariha Khalid ◽  
Brian C. Healy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Automated Segmentation ◽  
Whole Brain ◽  
3T Mri ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

scholarly journals Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

2018 ◽  
Vol 40 (1) ◽  
pp. 99-106 ◽  
Author(s):  
G. Pontillo ◽  
S. Cocozza ◽  
R. Lanzillo ◽  
C. Russo ◽  
M.D. Stasi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Multimodal Mri ◽  
Deep Gray Matter ◽  
Mri Study

scholarly journals What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?

2018 ◽  
Vol 40 (1) ◽  
pp. 107-108 ◽  
Author(s):  
M.M. Schoonheim ◽  
J.J.G. Geurts
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis

Neurology ◽  
2019 ◽  
Vol 93 (14) ◽  
pp. e1348-e1359 ◽  
Author(s):  
Anand J.C. Eijlers ◽  
Iris Dekker ◽  
Martijn D. Steenwijk ◽  
Kim A. Meijer ◽  
Hanneke E. Hulst ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Structural Mri ◽  
Cortical Atrophy ◽  
Lesion Volume ◽  
Volume Increase ◽  
Atrophy Rate ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

ObjectiveTo determine which pathologic process could be responsible for the acceleration of cognitive decline during the course of multiple sclerosis (MS), using longitudinal structural MRI, which was related to cognitive decline in relapsing-remitting MS (RRMS) and progressive MS (PMS).MethodsA prospective cohort of 230 patients with MS (179 RRMS and 51 PMS) and 59 healthy controls was evaluated twice with 5-year (mean 4.9, SD 0.94) interval during which 22 patients with RRMS converted to PMS. Annual rates of cortical and deep gray matter atrophy as well as lesion volume increase were computed on longitudinal (3T) MRI data and correlated to the annual rate of cognitive decline as measured using an extensive cognitive evaluation at both time points.ResultsThe deep gray matter atrophy rate did not differ between PMS and RRMS (−0.82%/year vs −0.71%/year, p = 0.11), while faster cortical atrophy was observed in PMS (−0.87%/year vs −0.48%/year, p < 0.01). Similarly, faster cognitive decline was observed in PMS compared to RRMS (p < 0.01). Annual cognitive decline was related to the rate of annual lesion volume increase in stable RRMS (r = −0.17, p = 0.03) to the rate of annual deep gray matter atrophy in converting RRMS (r = 0.50, p = 0.02) and annual cortical atrophy in PMS (r = 0.35, p = 0.01).ConclusionsThese results indicate that cortical atrophy and cognitive decline accelerate together during the course of MS. Substrates of cognitive decline shifted from worsening lesional pathology in stable RRMS to deep gray matter atrophy in converting RRMS and to accelerated cortical atrophy in PMS only.

scholarly journals Deep gray matter atrophy in multiple sclerosis: A tensor based morphometry

2009 ◽  
Vol 282 (1-2) ◽  
pp. 39-46 ◽  
Author(s):  
Guozhi Tao ◽  
Sushmita Datta ◽  
Renjie He ◽  
Flavia Nelson ◽  
Jerry S. Wolinsky ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter
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