Myelin Water Fraction and Intra/Extracellular Water Geometric Mean T 2 Normative Atlases for the Cervical Spinal Cord from 3T MRI

2019 ◽  
Vol 30 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Hanwen Liu ◽  
Emil Ljungberg ◽  
Adam V. Dvorak ◽  
Lisa Eunyoung Lee ◽  
Jackie T. Yik ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Geometric Mean ◽  
Extracellular Water ◽  
3T Mri ◽  
Water Fraction ◽  
Myelin Water Fraction

Myelin Water Fraction in Human Cervical Spinal Cord In Vivo

2006 ◽  
Vol 30 (2) ◽  
pp. 304-306 ◽  
Author(s):  
Yijing Wu ◽  
Andrew L. Alexander ◽  
John O. Fleming ◽  
Ian D. Duncan ◽  
Aaron S. Field
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Water Fraction ◽  
Myelin Water Fraction

scholarly journals Multicenter measurements of myelin water fraction and geometric mean T2: Intra- and intersite reproducibility

2013 ◽  
Vol 38 (6) ◽  
pp. 1445-1453 ◽  
Author(s):  
Sandra M. Meyers ◽  
Irene M. Vavasour ◽  
Burkhard Mädler ◽  
Trudy Harris ◽  
Eric Fu ◽  
...  
Keyword(s):  
Geometric Mean ◽  
Water Fraction ◽  
Myelin Water Fraction

scholarly journals The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Thomas Wimmer ◽  
Frank Schreiber ◽  
Nathalie Hensiek ◽  
Cornelia Garz ◽  
Jörn Kaufmann ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Cross Sectional ◽  
3T Mri ◽  
Upper Cervical

scholarly journals Microstructure of Human Corpus Callosum across the Lifespan: Regional Variations in Axon Caliber, Density, and Myelin Content

2020 ◽  
Author(s):  
Jonathan D Lynn ◽  
Chaitali Anand ◽  
Muzamil Arshad ◽  
Roya Homayouni ◽  
David R Rosenberg ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Age Differences ◽  
Geometric Mean ◽  
Large Diameter ◽  
Fiber Density ◽  
Regional Patterns ◽  
Water Fraction ◽  
Age Related ◽  
Developmental Progression ◽  
Myelin Water Fraction

Abstract The myeloarchitecture of the corpus callosum (CC) is characterized as a mosaic of distinct differences in fiber density of small- and large-diameter axons along the anterior–posterior axis; however, regional and age differences across the lifespan are not fully understood. Using multiecho T2 magnetic resonance imaging combined with multi-T2 fitting, the myelin water fraction (MWF) and geometric-mean of the intra-/extracellular water T2 (geomT2IEW) in 395 individuals (7–85 years; 41% males) were examined. The approach was validated where regional patterns along the CC closely resembled the histology; MWF matched mean axon diameter and geomT2IEW mirrored the density of large-caliber axons. Across the lifespan, MWF exhibited a quadratic association with age in all 10 CC regions with evidence of a positive linear MWF-age relationship among younger participants and minimal age differences in the remainder of the lifespan. Regarding geomT2IEW, a significant linear age × region interaction reflected positive linear age dependence mostly prominent in the regions with the highest density of small-caliber fibers—genu and splenium. In all, these two indicators characterize distinct attributes that are consistent with histology, which is a first. In addition, these results conform to rapid developmental progression of CC myelination leveling in middle age as well as age-related degradation of axon sheaths in older adults.

scholarly journals Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Adam V. Dvorak ◽  
Emil Ljungberg ◽  
Irene M. Vavasour ◽  
Lisa Eunyoung Lee ◽  
Shawna Abel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Steady State ◽  
Cervical Spinal Cord ◽  
Traditional Approach ◽  
Quantitative Mri ◽  
Z Score ◽  
Water Fraction ◽  
Multiple Sclerosis Patients ◽  
Myelin Imaging

AbstractThe traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated “mcDESPOT”, uses a more efficient steady-state acquisition to generate an equivalent metric (fM). Although previous studies have demonstrated inherent instability and bias in the complex mcDESPOT analysis procedure, fM has often been used as a surrogate for MWF. We produced and compared multivariate atlases of MWF and fM in healthy human brain and cervical spinal cord (available online) and compared their ability to detect multiple sclerosis pathology. A significant bias was found in all regions (p < 10–5), albeit reversed for spinal cord (fM-MWF =  − 3.4%) compared to brain (+ 6.2%). MWF and fM followed an approximately linear relationship for regions with MWF <  ~ 10%. For MWF >  ~ 10%, the relationship broke down and fM no longer increased in tandem with MWF. For multiple sclerosis patients, MWF and fM Z score maps showed overlapping areas of low Z score and similar trends between patients and brain regions, although those of fM generally had greater spatial extent and magnitude of severity. These results will guide future choice of myelin-sensitive quantitative MRI and improve interpretation of studies using either myelin imaging approach.

Diffusion tensor imaging of the cervical spinal cord in healthy adult population: normative values and measurement reproducibility at 3T MRI

2014 ◽  
Vol 55 (4) ◽  
pp. 478-485 ◽  
Author(s):  
Antti Brander ◽  
Eerika Koskinen ◽  
Teemu M Luoto ◽  
Ullamari Hakulinen ◽  
Mika Helminen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Healthy Adult ◽  
Diffusion Tensor ◽  
Cervical Spinal Cord ◽  
Adult Population ◽  
Normative Values ◽  
3T Mri ◽  
Measurement Reproducibility
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