Brain Volume Loss During the First Year of Interferon-Beta Treatment in Multiple Sclerosis: Baseline Inflammation and Regional Brain Volume Dynamics

2016 ◽  
Vol 26 (5) ◽  
pp. 532-538 ◽  
Author(s):  
Angela Vidal-Jordana ◽  
Jaume Sastre-Garriga ◽  
Francisco Pérez-Miralles ◽  
Deborah Pareto ◽  
Jordi Rio ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Beta ◽  
Brain Volume ◽  
First Year ◽  
Volume Loss ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Regional Brain Volume

Patterns of regional brain volume loss in multiple sclerosis: a cluster analysis

2019 ◽  
Vol 267 (2) ◽  
pp. 395-405
Author(s):  
Juichi Fujimori ◽  
Kazuo Fujihara ◽  
Ryo Ogawa ◽  
Toru Baba ◽  
Mike Wattjes ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cluster Analysis ◽  
Brain Volume ◽  
Volume Loss ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Regional Brain Volume

scholarly journals Peri‐ictal hypoxia is related to extent of regional brain volume loss accompanying generalized tonic‐clonic seizures

Epilepsia ◽  
2020 ◽  
Vol 61 (8) ◽  
pp. 1570-1580
Author(s):  
Luke A. Allen ◽  
Ronald M. Harper ◽  
Sjoerd B. Vos ◽  
Catherine A. Scott ◽  
Nuria Lacuey ◽  
...  
Keyword(s):  
Brain Volume ◽  
Volume Loss ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Clonic Seizures ◽  
Regional Brain Volume

scholarly journals Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function

2015 ◽  
Vol 168 (1-2) ◽  
pp. 297-304 ◽  
Author(s):  
Joyce Y. Guo ◽  
Sanna Huhtaniska ◽  
Jouko Miettunen ◽  
Erika Jääskeläinen ◽  
Vesa Kiviniemi ◽  
...  
Keyword(s):  
Antipsychotic Medication ◽  
Brain Volume ◽  
Social Function ◽  
Volume Loss ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Regional Brain Volume

scholarly journals Sex-Specific Cognitive Deficits and Regional Brain Volume Loss in Mice Exposed to Chronic, Sublethal Hypoxia

2011 ◽  
Vol 70 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Wen-Chun J Lan ◽  
Matthew Priestley ◽  
Sonia R Mayoral ◽  
Lu Tian ◽  
Mehrdad Shamloo ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Brain Volume ◽  
Volume Loss ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Regional Brain Volume

Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: A voxel‐based morphometric study

2007 ◽  
Vol 8 (6) ◽  
pp. 328-336 ◽  
Author(s):  
Jan Kassubek ◽  
Freimut D. Juengling ◽  
Annette Baumgartner ◽  
Alexander Unrath ◽  
Albert C. Ludolph ◽  
...  
Keyword(s):  
Brain Volume ◽  
Spastic Paraparesis ◽  
Morphometric Study ◽  
Volume Loss ◽  
Hereditary Spastic Paraparesis ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Regional Brain Volume

Pathological cut-offs of global and regional brain volume loss in multiple sclerosis

2017 ◽  
Vol 25 (4) ◽  
pp. 541-553 ◽  
Author(s):  
Tomas Uher ◽  
Manuela Vaneckova ◽  
Jan Krasensky ◽  
Lukas Sobisek ◽  
Michaela Tyblova ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Grey Matter ◽  
Brain Volume ◽  
Healthy Controls ◽  
Volume Loss ◽  
Whole Brain ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Mri Scans ◽  
Regional Brain Volume

Background: Volumetric MRI surrogate markers of disease progression are lacking. Objective: To establish cut-off values of brain volume loss able to discriminate between healthy controls and MS patients. Methods: In total, 386 patients after first demyelinating event suggestive of MS (CIS), 964 relapsing-remitting MS (RRMS) patients, 63 secondary-progressive MS (SPMS) patients and 58 healthy controls were included in this longitudinal study. A total of 11,438 MRI scans performed on the same MRI scanner with the same protocol were analysed. Annualised percentage changes of whole brain, grey matter, thalamus and corpus callosum volumes were estimated. We investigated cut-offs able to discriminate between healthy controls and MS patients. Results: At a predefined specificity of 90%, the annualised percentage change cut-off of corpus callosum volume (−0.57%) was able to distinguish between healthy controls and patients with the highest sensitivity (51% in CIS, 48% in RRMS and 42% in SPMS patients). Lower sensitivities (22%−49%) were found for cut-offs of whole brain, grey matter and thalamic volume loss. Among CIS and RRMS patients, cut-offs were associated with greater accumulation of disability. Conclusion: We identified cut-offs of annualised global and regional brain volume loss rates able to discriminate between healthy controls and MS patients.

P 6 Eye movement disturbances are associated with regional brain volume loss in neurodegenerative Parkinsonism

2017 ◽  
Vol 128 (10) ◽  
pp. e328
Author(s):  
O. Vintonyak ◽  
M. Gorges ◽  
H.P. Müller ◽  
E.H. Pinkhardt ◽  
A.C. Ludolph ◽  
...  
Keyword(s):  
Eye Movement ◽  
Brain Volume ◽  
Volume Loss ◽  
Brain Volume Loss ◽  
Regional Brain ◽  
Regional Brain Volume

scholarly journals Learning ability correlates with brain atrophy and disability progression in RRMS

2018 ◽  
Vol 90 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Maria Pia Sormani ◽  
Nicola De Stefano ◽  
Gavin Giovannoni ◽  
Dawn Langdon ◽  
Daniela Piani-Meier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Volume ◽  
Practice Effect ◽  
Wilcoxon Test ◽  
Learning Ability ◽  
Lesion Volume ◽  
Volume Loss ◽  
Disability Progression ◽  
Brain Volume Loss ◽  
Quartile Group

ObjectiveTo assess the prognostic value of practice effect on Paced Auditory Serial Addition Test (PASAT) in multiple sclerosis.MethodsWe compared screening (day −14) and baseline (day 0) PASAT scores of 1009 patients from the FTY720 Research Evaluating Effects of Daily Oral therapy in Multiple Sclerosis (FREEDOMS) trial. We grouped patients into high and low learners if their PASAT score change was above or below the median change in their screening PASAT quartile group. We used Wilcoxon test to compare baseline disease characteristics between high and low learners, and multiple regression models to assess the respective impact of learning ability, baseline normalised brain volume and treatment on brain volume loss and 6-month confirmed disability progression over 2 years.ResultsThe mean PASAT score at screening was 45.38, increasing on average by 3.18 from day −14 to day 0. High learners were younger (p=0.003), had lower Expanded Disability Status Scale score (p=0.031), higher brain volume (p<0.001) and lower T2 lesion volume (p=0.009) at baseline. Learning status was not significantly associated with disability progression (HR=0.953, p=0.779), when adjusting for baseline normalised brain volume, screening PASAT score and treatment arm. However, the effect of fingolimod on disability progression was more pronounced in high learners (HR=0.396, p<0.001) than in low learners (HR=0.798, p=0.351; p for interaction=0.05). Brain volume loss at month 24 tended to be higher in low learners (0.17%, p=0.058), after adjusting for the same covariates.ConclusionsShort-term practice effects on PASAT are related to brain volume, disease severity and age and have clinically meaningful prognostic implications. High learners benefited more from fingolimod treatment.

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