scholarly journals Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity

2017 ◽  
Vol 282 (2) ◽  
pp. 187-201 ◽  
Author(s):  
M.-R. Taskinen ◽  
S. Söderlund ◽  
L. H. Bogl ◽  
A. Hakkarainen ◽  
N. Matikainen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lipid Metabolism ◽  
Adverse Effects ◽  
Abdominal Obesity ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

scholarly journals Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women

2015 ◽  
Vol 4 (10) ◽  
Author(s):  
Leanne Hodson ◽  
Rajarshi Banerjee ◽  
Belén Rial ◽  
Wiebke Arlt ◽  
Martin Adiels ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Abdominal Obesity ◽  
Menopausal Status ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

A Cross-Sectional Survey of Cardiometabolic Risk Factors in Canadian Primary Care Patients with Abdominal Obesity

2014 ◽  
Vol 38 (5) ◽  
pp. S45
Author(s):  
David C.W. Lau ◽  
Lawrence A. Leiter ◽  
Jacques J.G. Genest ◽  
Stewart B. Harris ◽  
Peter Selby ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Care ◽  
Abdominal Obesity ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Primary Care Patients

scholarly journals Relationship of TSH levels with cardiometabolic risk factors in US youth aged 12-18 years and population-based reference percentiles for thyroid function tests.

2020 ◽  
Author(s):  
Xinlei Chen ◽  
Shuliang Deng ◽  
Cecilia Sena ◽  
Chuhan Zhou ◽  
Vidhu V Thaker
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Abdominal Obesity ◽  
Cardiometabolic Risk ◽  
Normal Weight ◽  
The Body ◽  
Cardiometabolic Risk Factors ◽  
Thyroid Function Tests ◽  
Cross Sectional ◽  
Tsh Levels

Context: Thyroid hormones play an important role in the metabolic homeostasis of the body and have been associated with cardiometabolic risk. Objective: To examine the association of cardiometabolic risk factors (CMRF) with TSH levels in youth at population level in the US. Design & Setting: Cross-sectional study of youth aged 12-18 years without known thyroid abnormalities from National Health and Nutrition Examination Survey 1999-2012. Subclinical hypothyroidism (SH) was defined as TSH levels 4.5-10 mIU/L. Assessed CMRF included abdominal obesity (waist circumference > 90th percentile), hypertriglyceridemia (TG ≥ 130 mg/dL), low HDL cholesterol (HDL-C < 40 mg/dL), elevated blood pressure (SBP and DBP ≥ 90th percentile), hyperglycemia (FBG ≥ 100 mg/dL, or known diabetes), insulin resistance (HOMA-IR > 3.16) and elevated alanine transferase (ALT ≥ 50 U/L for boys and ≥ 44 U/L for girls). Age and sex- specific percentiles for thyroid parameters were calculated for youth with normal weight. Results: In this cohort of youth (51.3% male), 31.2% had overweight/obesity. The prevalence of SH was 2.0 % (95% CI 1.2-3.1). The median TSH levels were higher in youth with overweight/obesity (p<.001). Adjusting for age, sex, race/ethnicity and level of obesity, youth with TSH in the 4th quantile had higher odds of abdominal obesity (OR 2.53 [1.43-4.46], p = .002), higher HOMA-IR (OR 2.82 [1.42-5.57], p=.003) and ≥ 2 CMRF (OR 2.20 [1.23-3.95], p=.009). Conclusions: The prevalence of SH is low in US youth. The higher odds of insulin resistance and CMRF in youth with TSH levels > 75th percentile requires further study.

scholarly journals Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

2011 ◽  
Vol 164 (4) ◽  
pp. 553-558 ◽  
Author(s):  
Sonya V Galcheva ◽  
Violeta M Iotova ◽  
Yoto T Yotov ◽  
Sergio Bernasconi ◽  
Maria E Street
Keyword(s):  
Risk Factors ◽  
Abdominal Obesity ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Cardiometabolic Risk Factors ◽  
Model Assessment ◽  
Cross Sectional ◽  
Prepubertal Children ◽  
Tnf Α

ObjectivesTo analyze the circulating levels of proinflammatory peptides in healthy prepubertal children in relation to abdominal obesity, measured by waist circumference (WC), and to investigate their interactions with cardiometabolic risk factors.Design and methodsA cross-sectional study of 137 healthy prepubertal children with a mean age of 8.0±0.1 years divided into three groups according to their WC as a measure of abdominal obesity: ‘normal-WC’ children (25th–75th percentile, n=48), ‘children at risk’ (75th–90th percentile, n=39), and ‘abdominally obese’ (≥90th percentile, n=50) children. Auxological measurements and blood pressure (BP) were taken. Fasting levels of high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL6), tumor necrosis factor-α (TNF-α), glucose, insulin, and lipid profile were measured. Insulin resistance (IR) was assessed by homeostasis model assessment of IR (HOMA-IR).ResultsAbdominally obese children had significantly higher BP, insulin, HOMA-IR, total cholesterol and triglycerides (TG) compared with their normal-WC counterparts (P<0.05). HsCRP concentrations increased proportionally with the degree of abdominal obesity (r=0.443, P<0.0001), whereas IL6 and TNF-α were not significantly associated with any of the adiposity variables. After controlling for adiposity, hsCRP was significantly correlated with systolic BP (r=0.257, P=0.004), TNF-α levels were related to high-density lipoprotein cholesterol (HDL-C; r=−0.216, P=0.016) and TG (r=0.196, P=0.029), whereas the relationship between IL6 and HDL-C reduced its magnitude to an insignificant level (r=−0.173, P=0.055).ConclusionsHealthy prepubertal children with abdominal obesity have associated inflammatory and cardiometabolic alterations, interacting with each other.

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