Clinical pregnancy after deceased donor uterus transplantation: Lessons learned and future perspectives

2019 ◽  
Vol 45 (8) ◽  
pp. 1458-1465 ◽  
Author(s):  
Roman Chmel ◽  
Zlatko Pastor ◽  
Marta Novackova ◽  
Jan Matecha ◽  
Milos Cekal ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Clinical Pregnancy ◽  
Lessons Learned ◽  
Future Perspectives ◽  
Uterus Transplantation

Revaluation and lessons learned from the first 9 cases of a Czech uterus transplantation trial: Four deceased donor and 5 living donor uterus transplantations

2018 ◽  
Vol 19 (3) ◽  
pp. 855-864 ◽  
Author(s):  
Roman Chmel ◽  
Marta Novackova ◽  
Libor Janousek ◽  
Jan Matecha ◽  
Zlatko Pastor ◽  
...  
Keyword(s):  
Living Donor ◽  
Deceased Donor ◽  
Lessons Learned ◽  
Uterus Transplantation

scholarly journals Ethical and policy issues raised by uterus transplants

2019 ◽  
Vol 131 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Laura O’Donovan ◽  
Nicola Jane Williams ◽  
Stephen Wilkinson
Keyword(s):  
Deceased Donor ◽  
Access To Treatment ◽  
Policy Issues ◽  
Uterus Transplantation ◽  
Academic Literature ◽  
International Registry ◽  
Uterine Transplantation ◽  
Key Issues ◽  
Surgical Teams ◽  
Definition Of

Abstract Introduction In 2014, Brännström and colleagues reported the first human live birth following uterine transplantation (UTx). Research into this treatment for absolute uterine factor infertility has since grown with clinical trials currently taking place across centers in at least thirteen countries worldwide. Sources of data This review summarizes and critiques the academic literature on ethical and policy issues raised by UTx. Areas of agreement There is general agreement on the importance of risk reduction and, in principle, to the sharing and maintenance of patient data on an international registry. Areas of controversy There are numerous areas of controversy ranging from whether it is ethically justified to carry out uterus transplants at all (considering the associated health risks) to how deceased donor organs for transplant should be allocated. This review focuses on three key issues: the choice between deceased and living donors, ensuring valid consent to the procedure and access to treatment. Growing points UTx is presently a novel and rare procedure but is likely to become more commonplace in the foreseeable future, given the large number of surgical teams working on it worldwide. Areas timely for developing research Uterus transplantation requires us to re-examine fundamental questions about the ethical and social value of gestation. If eventually extended to transgender women or even to men, it may also require us to reconceptualize what it is to be a ‘father’ or to be a ‘mother’, and the definition of these terms in law.

Uterus transplantation from a deceased donor

The Lancet ◽  
2018 ◽  
Vol 392 (10165) ◽  
pp. 2657-2658 ◽  
Author(s):  
Cesar Diaz-Garcia ◽  
Antonio Pellicer
Keyword(s):  
Deceased Donor ◽  
Uterus Transplantation

Lessons Learned and Future Perspectives

2021 ◽  
pp. 295-319
Author(s):  
Antonio Vittorino Gaddi ◽  
Michele Nichelatti ◽  
Enrico Cipolla
Keyword(s):  
Lessons Learned ◽  
Future Perspectives

Live versus deceased donor in uterus transplantation

2019 ◽  
Vol 112 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Niclas Kvarnström ◽  
Anders Enskog ◽  
Pernilla Dahm-Kähler ◽  
Mats Brännström
Keyword(s):  
Deceased Donor ◽  
Uterus Transplantation

scholarly journals Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success

2017 ◽  
Vol 17 (11) ◽  
pp. 2901-2910 ◽  
Author(s):  
G. Testa ◽  
E. C. Koon ◽  
L. Johannesson ◽  
G. J. McKenna ◽  
T. Anthony ◽  
...  
Keyword(s):  
Living Donor ◽  
Lessons Learned ◽  
Technical Success ◽  
Uterus Transplantation

scholarly journals The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

2019 ◽  
Vol 8 (6) ◽  
pp. 760 ◽  
Author(s):  
Antoine Tardieu ◽  
Ludivine Dion ◽  
Vincent Lavoué ◽  
Pauline Chazelas ◽  
Pierre Marquet ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Cold Ischemia ◽  
Uterus Transplantation ◽  
Uterine Contractions ◽  
Live Donors ◽  
Promising Treatment ◽  
Deceased Donors ◽  
Ischemia Tolerance ◽  
Large Animals

Introduction: Uterus transplantation (UTx) is a promising treatment for uterine infertility that has resulted in several births since 2014. Ischemia is a key step in organ transplantation because it may lead to changes jeopardizing graft viability. Method: We performed a systematic review of animal and human studies relating to uterine ischemia. Results: We retained 64 studies published since 2000. There were 35 studies in animals, 24 in humans, and five literature reviews. Modest preliminary results in large animals and humans are limited but encouraging. In small animals, pregnancies have been reported to occur after 24 h of cold ischemia (CI). In ewes, uterine contractions have been detected after 24 h of CI. Furthermore, it has been shown in animals that uterine tolerance to CI and to warm ischemia (WI) can be increased by pharmacological products. In women, mean CI time in studies of births from uteri obtained from live donors was between 2 h 47 min and 6 h 20 min from a deceased donor; with only one birth in this case. Muscle contractions have also been demonstrated in myometrial samples from women, after six or more hours of CI. Conclusion: The uterus seems to be able to tolerate a prolonged period of CI, of at least six hours. Studies of the ischemia tolerance of the uterus and ways to improve it are essential for the development of UTx, particularly for procedures using grafts from deceased donors.

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