Revaluation and lessons learned from the first 9 cases of a Czech uterus transplantation trial: Four deceased donor and 5 living donor uterus transplantations

2018 ◽  
Vol 19 (3) ◽  
pp. 855-864 ◽  
Author(s):  
Roman Chmel ◽  
Marta Novackova ◽  
Libor Janousek ◽  
Jan Matecha ◽  
Zlatko Pastor ◽  
...  
Keyword(s):  
Living Donor ◽  
Deceased Donor ◽  
Lessons Learned ◽  
Uterus Transplantation

scholarly journals Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success

2017 ◽  
Vol 17 (11) ◽  
pp. 2901-2910 ◽  
Author(s):  
G. Testa ◽  
E. C. Koon ◽  
L. Johannesson ◽  
G. J. McKenna ◽  
T. Anthony ◽  
...  
Keyword(s):  
Living Donor ◽  
Lessons Learned ◽  
Technical Success ◽  
Uterus Transplantation

Clinical pregnancy after deceased donor uterus transplantation: Lessons learned and future perspectives

2019 ◽  
Vol 45 (8) ◽  
pp. 1458-1465 ◽  
Author(s):  
Roman Chmel ◽  
Zlatko Pastor ◽  
Marta Novackova ◽  
Jan Matecha ◽  
Milos Cekal ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Clinical Pregnancy ◽  
Lessons Learned ◽  
Future Perspectives ◽  
Uterus Transplantation

scholarly journals Prediction model for early graft failure after liver transplantation using aspartate aminotransferase, total bilirubin and coagulation factor

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinsoo Rhu ◽  
Jong Man Kim ◽  
Kyunga Kim ◽  
Heejin Yoo ◽  
Gyu-Seong Choi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Prediction Model ◽  
Aspartate Aminotransferase ◽  
Graft Failure ◽  
Living Donor ◽  
Total Bilirubin ◽  
Deceased Donor ◽  
Time Dependent ◽  
Early Graft ◽  
Early Graft Failure

AbstractThis study was designed to build models predicting early graft failure after liver transplantation. Cox regression model for predicting early graft failure after liver transplantation using post-transplantation aspartate aminotransferase, total bilirubin, and international normalized ratio of prothrombin time was constructed based on data from both living donor (n = 1153) and deceased donor (n = 359) liver transplantation performed during 2004 to 2018. The model was compared with Model for Early Allograft Function Scoring (MEAF) and early allograft dysfunction (EAD) with their C-index and time-dependent area-under-curve (AUC). The C-index of the model for living donor (0.73, CI = 0.67–0.79) was significantly higher compared to those of both MEAF (0.69, P = 0.03) and EAD (0.66, P = 0.001) while C-index for deceased donor (0.74, CI = 0.65–0.83) was only significantly higher compared to C-index of EAD. (0.66, P = 0.002) Time-dependent AUC at 2 weeks of living donor (0.96, CI = 0.91–1.00) and deceased donor (0.98, CI = 0.96–1.00) were significantly higher compared to those of EAD. (both 0.83, P < 0.001 for living donor and deceased donor) Time-dependent AUC at 4 weeks of living donor (0.93, CI = 0.86–0.99) was significantly higher compared to those of both MEAF (0.87, P = 0.02) and EAD. (0.84, P = 0.02) Time-dependent AUC at 4 weeks of deceased donor (0.94, CI = 0.89–1.00) was significantly higher compared to both MEAF (0.82, P = 0.02) and EAD. (0.81, P < 0.001). The prediction model for early graft failure after liver transplantation showed high predictability and validity with higher predictability compared to traditional models for both living donor and deceased donor liver transplantation.

Liberal Policy in Living Donor Liver Transplantation for Hepatocellular Carcinoma: Lessons Learned

2008 ◽  
Vol 54 (2) ◽  
pp. 377-384 ◽  
Author(s):  
Georgios C. Sotiropoulos ◽  
Hauke Lang ◽  
George Sgourakis ◽  
Silvio Nadalin ◽  
Ernesto P. Molmenti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Lessons Learned ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Liberal Policy

scholarly journals Ethical and policy issues raised by uterus transplants

2019 ◽  
Vol 131 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Laura O’Donovan ◽  
Nicola Jane Williams ◽  
Stephen Wilkinson
Keyword(s):  
Deceased Donor ◽  
Access To Treatment ◽  
Policy Issues ◽  
Uterus Transplantation ◽  
Academic Literature ◽  
International Registry ◽  
Uterine Transplantation ◽  
Key Issues ◽  
Surgical Teams ◽  
Definition Of

Abstract Introduction In 2014, Brännström and colleagues reported the first human live birth following uterine transplantation (UTx). Research into this treatment for absolute uterine factor infertility has since grown with clinical trials currently taking place across centers in at least thirteen countries worldwide. Sources of data This review summarizes and critiques the academic literature on ethical and policy issues raised by UTx. Areas of agreement There is general agreement on the importance of risk reduction and, in principle, to the sharing and maintenance of patient data on an international registry. Areas of controversy There are numerous areas of controversy ranging from whether it is ethically justified to carry out uterus transplants at all (considering the associated health risks) to how deceased donor organs for transplant should be allocated. This review focuses on three key issues: the choice between deceased and living donors, ensuring valid consent to the procedure and access to treatment. Growing points UTx is presently a novel and rare procedure but is likely to become more commonplace in the foreseeable future, given the large number of surgical teams working on it worldwide. Areas timely for developing research Uterus transplantation requires us to re-examine fundamental questions about the ethical and social value of gestation. If eventually extended to transgender women or even to men, it may also require us to reconceptualize what it is to be a ‘father’ or to be a ‘mother’, and the definition of these terms in law.

Uterus transplantation from a deceased donor

The Lancet ◽  
2018 ◽  
Vol 392 (10165) ◽  
pp. 2657-2658 ◽  
Author(s):  
Cesar Diaz-Garcia ◽  
Antonio Pellicer
Keyword(s):  
Deceased Donor ◽  
Uterus Transplantation

scholarly journals Aggravation of fibrin deposition and microthrombus formation within the graft during kidney transplantation

2021 ◽  
Author(s):  
Tamar A.J. van den Berg ◽  
Marius C. van den Heuvel ◽  
Janneke Wiersema-Buist ◽  
Jelle Adelmeijer ◽  
Gertrude J. Nieuwenhuijs-Moeke ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Living Donor ◽  
Graft Function ◽  
Deceased Donor ◽  
Potential Difference ◽  
Fibrin Deposition ◽  
Peritubular Capillaries ◽  
Deposition Intensity

Abstract In kidney transplantation, microthrombi and fibrin deposition may lead to local perfusion disorders and subsequently poor initial graft function. Microthrombi are often regarded as donor-derived. However, the incidence, time of development, and potential difference between living donor kidneys (LDK) and deceased donor kidneys(DDK), remains unclear. Two open-needle biopsies, taken at preimplantation and after reperfusion, were obtained from 17 LDK and 28 DDK transplanted between 2005 and 2008. Paraffin-embedded sections were immunohistochemically stained with anti-fibrinogen antibody. Fibrin deposition intensity in peritubular capillaries(PTC) and glomeruli was categorized as negative, weak, moderate or strong and the number of microthrombi/mm2 was quantified. Reperfusion biopsies showed more fibrin deposition (20–100% moderate/strong, p < 0.001) and more microthrombi/mm2 (0.97 ± 1.12 vs. 0.28 ± 0.53, p < 0.01) than preimplantation biopsies. In addition, more microthrombi/mm2 (0.38 ± 0.61 vs. 0.09 ± 0.22, p = 0.02) and stronger fibrin intensity in glomeruli (28% vs. 0%, p < 0.01) and PTC (14% vs. 0%, p = 0.02) were observed in preimplantation DDK than LDK biopsies. After reperfusion, microthrombi/mm2 were comparable (p = 0.23) for LDK (0.09 ± 0.22 to 0.76 ± 0.49, p = 0.03) and DDK (0.38 ± 0.61 to 0.90 ± 1.11, p = 0.07). Upon reperfusion, there is an aggravation of microthrombus formation and fibrin deposition within the graft. The prominent increase of microthrombi in LDK indicates that they are not merely donor-derived.

scholarly journals Hospitalization Rates Before and After Adult-to-Adult Living Donor or Deceased Donor Liver Transplantation

2010 ◽  
Vol 251 (3) ◽  
pp. 542-549 ◽  
Author(s):  
Robert M. Merion ◽  
Tempie H. Shearon ◽  
Carl L. Berg ◽  
James E. Everhart ◽  
Michael M. Abecassis ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Deceased Donor ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Hospitalization Rates ◽  
Deceased Donor Liver Transplantation ◽  
Before And After
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