Expressions of programmed death (PD)-1 and PD-1 ligand (PD-L1) in cervical intraepithelial neoplasia and cervical squamous cell carcinomas are of prognostic value and associated with human papillomavirus status

2017 ◽  
Vol 43 (10) ◽  
pp. 1602-1612 ◽  
Author(s):  
Wen Yang ◽  
Yan-Ping Lu ◽  
Yi-Zhou Yang ◽  
Jia-Rui Kang ◽  
Yi-Duo Jin ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Intraepithelial Neoplasia ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Intraepithelial Neoplasia ◽  
Squamous Cell Carcinomas ◽  
Programmed Death

Human papillomavirus reduces the prognostic value of nodal involvement in tonsillar squamous cell carcinomas

2009 ◽  
Vol 119 (10) ◽  
pp. 1951-1957 ◽  
Author(s):  
Jos M. J. A. A. Straetmans ◽  
Nadine Olthof ◽  
Jeroen J. Mooren ◽  
Jos de Jong ◽  
Ernst-Jan M. Speel ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Squamous Cell Carcinomas ◽  
Nodal Involvement

scholarly journals Human Papillomavirus Genotyping and E6/E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Elpida Tsimplaki ◽  
Elena Argyri ◽  
Lina Michala ◽  
Maria Kouvousi ◽  
Aikaterini Apostolaki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Mrna Expression ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Squamous Cell Carcinomas ◽  
Increased Risk ◽  
Hpv Genotypes ◽  
Risk Of Progression

A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16. The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs. HPV was identified in 56% of VAIN and 50% of vaginal SCCs, 71.4% of VIN and 50% of vulvar SCCs. E6/E7 mRNA expression was found in one-third of VAIN and in all vaginal SCCs, 42.9% of VIN and 83.3% of vulvar SCCs. Our data indicated that HPV 16 was the commonest genotype identified in VAIN and VIN and the only genotype found in SCCs of the vagina and vulva. These findings may suggest, in accordance with other studies, that mRNA assay might be useful in triaging lesions with increased risk of progression to cancer.

scholarly journals Expression of FasL in squamous cell carcinomas of the cervix and cervical intraepithelial neoplasia and its role in tumor escape mechanism

Cancer ◽  
2006 ◽  
Vol 106 (5) ◽  
pp. 1065-1077 ◽  
Author(s):  
Ramy Ibrahim ◽  
Helen Frederickson ◽  
Allyson Parr ◽  
Yvona Ward ◽  
Joel Moncur ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia ◽  
Squamous Cell Carcinomas ◽  
Tumor Escape ◽  
Escape Mechanism ◽  
Tumor Escape Mechanism
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