scholarly journals Expression of FasL in squamous cell carcinomas of the cervix and cervical intraepithelial neoplasia and its role in tumor escape mechanism

Cancer ◽  
2006 ◽  
Vol 106 (5) ◽  
pp. 1065-1077 ◽  
Author(s):  
Ramy Ibrahim ◽  
Helen Frederickson ◽  
Allyson Parr ◽  
Yvona Ward ◽  
Joel Moncur ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia ◽  
Squamous Cell Carcinomas ◽  
Tumor Escape ◽  
Escape Mechanism ◽  
Tumor Escape Mechanism

The role of microsatellite instability in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix

2003 ◽  
Vol 89 (3) ◽  
pp. 434-439 ◽  
Author(s):  
Yick-Fu Wong ◽  
Tak-Hong Cheung ◽  
Kin-Yan Poon ◽  
Vivian Wei Wang ◽  
James C.B Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Cervical Intraepithelial Neoplasia ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia

Methylation of the IL-12Rβ2 Gene as Novel Tumor Escape Mechanism for Pediatric B-Acute Lymphoblastic Leukemia Cells

2006 ◽  
Vol 66 (8) ◽  
pp. 3978-3980 ◽  
Author(s):  
Irma Airoldi ◽  
Claudia Cocco ◽  
Emma Di Carlo ◽  
Silvia Disarò ◽  
Emanuela Ognio ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Tumor Escape ◽  
Escape Mechanism ◽  
Tumor Escape Mechanism

Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status

2008 ◽  
Vol 61 (9) ◽  
pp. 1034-1037 ◽  
Author(s):  
S Aulmann ◽  
J Schleibaum ◽  
R Penzel ◽  
P Schirmacher ◽  
G Gebauer ◽  
...  
Keyword(s):  
Squamous Cell ◽  
P53 Protein ◽  
In Situ Hybridisation ◽  
Intraepithelial Neoplasia ◽  
Squamous Cell Carcinomas ◽  
Invasive Squamous Cell Carcinoma ◽  
Fluorescence In Situ Hybridisation ◽  
P53 Expression ◽  
Usual Type ◽  
Hpv Status

Aims:Two different forms of vulvar intraepithelial neoplasia (VIN) are recognised: (1) usual-type (bowenoid) VIN, which is related to high-risk papillomavirus infection, and (2) differentiated (simplex) VIN, which is associated with chronic inflammation. The aim of this study was to investigate the presence of chromosome 3q26 gains in the spectrum of precancerous lesions and invasive squamous cell carcinomas (SCCs) of the vulva.Methods:3q26 gains were analysed using fluorescence in situ hybridisation in a series of usual-type VINs, VINs of the differentiated type and invasive squamous cell carcinomas. In addition, all cases were examined for human papillomavirus (HPV) DNA, p53 mutations, and p16 and p53 protein expression.Results:Gains of chromosome 3q26 were present in all VINs of the differentiated type and in 50% of the usual-type VIN lesions. 81% of SCCs were positive for 3q26 gains irrespective of the HPV status and of the associated precursor lesion. HPV-associated lesions exhibited the typical, strong cytoplasmic p16 accumulation while mutated p53 was only detected in HPV-negative VINs or SCCs, and was associated with an overexpression of p53 protein.Conclusions:Immunohistochemical evaluation of p16 and p53 expression aids in the differential diagnosis of squamous cell alterations of the vulva. However, detection of 3q26 imbalance is of additional diagnostic value in difficult cases of HPV-unrelated usual-type VINs and VINs of the differentiated type.

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