Evaluation of vaginal fluid β-human chorionic gonadotrophin for the diagnosis of preterm premature rupture of membranes

2013 ◽  
Vol 39 (4) ◽  
pp. 777-782 ◽  
Author(s):  
Shohreh Bahasadri ◽  
Maryam Kashanian ◽  
Shokoufeh Khalili
Keyword(s):  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Vaginal Fluid ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture

scholarly journals PREMATURE RUPTURE OF MEMBRANES

2018 ◽  
Vol 25 (02) ◽  
pp. 168-172
Author(s):  
Azmeena Azam ◽  
Hafiz Maoz Husnain ◽  
Iqra Marryum
Keyword(s):  
Cross Sectional Study ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Vaginal Fluid ◽  
Effective Management ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Β Hcg ◽  
Hcg Test

Background: Pre-labour rupture of the membranes is one of the most commonclinical presentations in an obstetric setting. Early diagnosis is a major challenge faced byevery obstetrician and key to effective management and prevention of complications. As aresult of PROM, amniotic fluid that provides protection to the developing fetus is lost, exposingit to the outside environment. β-hCG is a hormone secreted by syncytiotrophoblasts found inamniotic fluid that can be studied for the evaluation of PROM. Objectives: To find the DiagnosticAccuracy of β human chorionic gonadotrophin test in vaginal washings taking amniotic fluidpooling as gold standard of diagnosing PROM. Study Design: Cross-sectional study. Setting:Unit II, Department of Obstetrics & Gynecology, Lahore General Hospital, Lahore. Period: Threemonths from January 2017 to March 2017. Material and methods: Females of age 18-40 yearswith gestational age >36weeks (calculated by LMP) complaining of PV leaking were includedin the study. Samples for β-hCG measurements were taken after informed consent. A β-hCGkit (Acu-check) was used for detection of β-hCG in vaginal fluid washings of pregnant women.Results: Diagnostic accuracy of β-hCG test was 91.66%. Sensitivity and specificity of β-hCGtest was 86.66% and 96.66%. Positive predictive and negative predictive value was 96.29% and87.87% respectively. Conclusion: Results of this study showed that for diagnosis of patientshaving PROM, beta human chorionic gonadotrophin (β-hCG) is a reliable, easy and quick test.

Daily monitoring of vaginal interleukin 6 as a predictor of intraamniotic inflammation after preterm premature rupture of membranes – a new method of sampling studied in a prospective multicenter trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Gregor Seliger ◽  
Michael Bergner ◽  
Roland Haase ◽  
Holger Stepan ◽  
Ekkehard Schleußner ◽  
...  
Keyword(s):  
Synthetic Fiber ◽  
New Technique ◽  
Vaginal Fluid ◽  
Daily Routine ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Daily Monitoring ◽  
Preterm Premature Rupture ◽  
A New Technique ◽  
Fluid Sampling

Abstract Objectives (A) To introduce a new technique for vaginal fluid sampling (biocompatible synthetic fiber sponge) and (B) evaluate the collected vaginal fluid interleukine-6 (IL-6vag)-concentration as a new diagnostic tool for daily monitoring of intrauterine inflammation after preterm premature rupture of membranes (PPROM). Secondary objectives were to compare the potential to predict an intrauterine inflammation with established inflammation parameters (e.g., maternal white blood cell count). Methods This prospective clinical case-control diagnostic accuracy multicenter study was performed with women after PPROM (gestational age 24.0/7 – 34.0/7 weeks). Sampling of vaginal fluid was performed once daily. IL-6vag was determined by electrochemiluminescence-immunoassay-kit. Neonatal outcome and placental histology results were used to retrospectively allocate the cohort into two subgroups: 1) inflammation and 2) no inflammation (controls). Results A total of 37 cases were included in the final analysis. (A): Measurement of IL-6 was successful in 86% of 172 vaginal fluid samples. (B): Median concentration of IL-6vag in the last vaginal fluid sample before delivery was significantly higher within the inflammation group (17,085 pg/mL) compared to the controls (1,888 pg/mL; p=0.01). By Youden’s index an optimal cut-off for prediction an intrauterine inflammation was: 6,417 pg/mL. Two days before delivery, in contrast to all other parameters IL-6vag remained the only parameter with a sufficient AUC of 0.877, p<0.001, 95%CI [0.670–1.000]. Conclusions This study established a new technique for vaginal fluid sampling, which permits assessment of IL-6vag concentration noninvasively in clinical daily routine monitoring.

C-reactive protein in vaginal fluid of patients with preterm premature rupture of membranes

2003 ◽  
Vol 82 (12) ◽  
pp. 1072-1079 ◽  
Author(s):  
Edoardo Di Naro ◽  
Fabio Ghezzi ◽  
Luigi Raio ◽  
Francesco Romano ◽  
Michel D. Mueller ◽  
...  
Keyword(s):  
Vaginal Fluid ◽  
C Reactive Protein ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Reactive Protein ◽  
Preterm Premature Rupture

scholarly journals Evaluation of Vaginal Fluid Urea and Creatinine as Biomarkers of Preterm Premature Rupture of Membranes

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Khaled slama ◽  
Ahmed Salah El din ◽  
Aymen Elgohary ◽  
Basma Mostafa
Keyword(s):  
Vaginal Fluid ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture
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