Intralesional pentoxifylline, triamcinolone acetonide and their combination for treatment of keloid scars

2021 ◽  
Author(s):  
Yasmin Magdy Abdulrahman Serag‐Eldin ◽  
Wael Hussein Mahmoud ◽  
Mohamed Mahmoud Gamea ◽  
Doaa Salah Hegab
Keyword(s):  
Triamcinolone Acetonide ◽  
Keloid Scars

scholarly journals Intralesional cryotherapy with triamcinolone and onabotulinumtoxinA injections for umbilical keloid: A case report

2021 ◽  
Vol 7 ◽  
pp. 205951312110490
Author(s):  
Jennifer VH Tran ◽  
Shantel DJ Lultschik ◽  
Sheetal Sapra ◽  
Kevin Dong ◽  
Klaudija Gusic ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Side Effects ◽  
Triamcinolone Acetonide ◽  
Treatment Plan ◽  
Treatment Options ◽  
High Patient Satisfaction ◽  
High Satisfaction ◽  
Keloid Scars ◽  
History Of ◽  
Low Rate

Introduction Keloid scars are therapeutically challenging and although many treatment options exist, there are no specific guidelines, and few reports have discussed keloids in the umbilical region. Methods Here, we present a successful treatment of a 31-year-old female with a history of a recurrent keloid in the umbilical region. The keloid was treated using intralesional cryotherapy followed by intralesional onabotulinumtoxinA and triamcinolone acetonide injections. Discussion The patient expressed high satisfaction, minimal side effects, and no recurrence. Conclusion Overall, due to the low rate of side effects, high patient satisfaction, and absence of recurrence, this treatment modality should be considered as an option for umbilical keloids. Lay Summary Background to subject: Keloids are a type of scar that are difficult to treat. There are many treatment options available, but there is no single best treatment for keloids that form around the belly button region. Question being asked: Is intralesional cryotherapy with intralesional onabotulinumtoxinA and triamcinolone acetonide injections effective at treating keloids in the belly button region? How the work was conducted: We treated a 31-year-old female with a keloid around the belly button region that returned after prior treatment. The keloid was treated using combination therapy of freezing the keloid from the inside out, which is called intralesional cryotherapy. This was followed by two types of injections, called onabotulinumtoxinA and triamcinolone acetonide, directly into the keloid. What we learned: Overall, due to the low rate of side effects, high patient satisfaction and the keloid not returning, this treatment plan should be considered as an option for keloids in the belly button region. What we did not learn: This treatment may or may not be effective and safe for all patients of all skin types and demographics as this treatment was performed for only one patient.

scholarly journals Effect of dehydroepiandroesterone and triamcinolone acetonide on 3T3-L1 cell line

2017 ◽  
Author(s):  
◽  
G. Gutiérrez-Iglesias
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Triamcinolone Acetonide ◽  
Biological Effects ◽  
Fibroblast Cell ◽  
Cell Protection ◽  
Molecular Alterations ◽  
Recommended Treatment ◽  
Keloid Scars ◽  
Anti Oxidant

The skin in the human is the largest organ, his integrity represents protection against various chemical, biological and mechanical agents. The injuries in this tissue are solved by forming a scar, however, different molecular alterations may overstimulate this process, leading to the formation of aberrant scars (hypertrophic or keloid). The most recommended treatment for such injuries is the intralesional application of triamcinolone acetonide (TA) and on the other hand, dehydroepiandrosterone (DHEA) is a pro-hormone that has a wide variety of biological effects such as regulation of the synthesis of collagen fibers, cell protection, anti-tumor properties, anti-inflammatory and anti-oxidant. In this paper, the combination of AT-DHEA on proliferation and cell death in fibroblast cell line 3T3-L1 was studied. The results showed that the AT 100 and 1000 M DHEA to inhibit proliferation by 50 and 40% respectively. The combination of AT-DHEA (10000-10 M) inhibits cell proliferation and induce programmed cell death, so this combination could be used in hypertrophic or keloid scars for disposal.

scholarly journals Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives

2018 ◽  
Vol Volume 11 ◽  
pp. 387-396 ◽  
Author(s):  
Marco Morelli Coppola ◽  
Rosa Salzillo ◽  
Francesco Segreto ◽  
Paolo Persichetti
Keyword(s):  
Triamcinolone Acetonide ◽  
Patient Selection ◽  
Intralesional Injection ◽  
Keloid Scars

scholarly journals Effect of dehydroepiandroesterone and triamcinolone acetonide on 3T3-L1 cell line

2017 ◽  
Author(s):  
◽  
G. Gutiérrez-Iglesias
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Triamcinolone Acetonide ◽  
Biological Effects ◽  
Fibroblast Cell ◽  
Cell Protection ◽  
Molecular Alterations ◽  
Recommended Treatment ◽  
Keloid Scars ◽  
Anti Oxidant

The skin in the human is the largest organ, his integrity represents protection against various chemical, biological and mechanical agents. The injuries in this tissue are solved by forming a scar, however, different molecular alterations may overstimulate this process, leading to the formation of aberrant scars (hypertrophic or keloid). The most recommended treatment for such injuries is the intralesional application of triamcinolone acetonide (TA) and on the other hand, dehydroepiandrosterone (DHEA) is a pro-hormone that has a wide variety of biological effects such as regulation of the synthesis of collagen fibers, cell protection, anti-tumor properties, anti-inflammatory and anti-oxidant. In this paper, the combination of AT-DHEA on proliferation and cell death in fibroblast cell line 3T3-L1 was studied. The results showed that the AT 100 and 1000 M DHEA to inhibit proliferation by 50 and 40% respectively. The combination of AT-DHEA (10000-10 M) inhibits cell proliferation and induce programmed cell death, so this combination could be used in hypertrophic or keloid scars for disposal.

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