Long‐term effectiveness of a hyaluronic acid soft tissue filler in patients with facial lipoatrophy, morphological asymmetry, or debilitating scars

2020 ◽  
Vol 19 (10) ◽  
pp. 2536-2541
Author(s):  
Doris Grablowitz ◽  
Zrinka Ivezic‐Schoenfeld ◽  
Ira G. Federspiel ◽  
Benjamin Gehl ◽  
Daisy Kopera ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Morphological Asymmetry ◽  
Facial Lipoatrophy ◽  
Soft Tissue Filler

scholarly journals Treatment of facial lipoatrophy, morphological asymmetry, or debilitating scars with the hyaluronic acid dermal filler Princess® FILLER

2018 ◽  
Vol Volume 11 ◽  
pp. 621-628 ◽  
Author(s):  
Daisy Kopera ◽  
Zrinka Ivezic-Schoenfeld ◽  
Ira G. Federspiel ◽  
Doris Grablowitz ◽  
Benjamin Gehl ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Dermal Filler ◽  
Morphological Asymmetry ◽  
Facial Lipoatrophy

Safe Glabellar Wrinkle Correction With Soft Tissue Filler Using Doppler Ultrasound

2020 ◽  
Author(s):  
Won Lee ◽  
Hyoung-Jin Moon ◽  
Ji-Soo Kim ◽  
Eun-Jung Yang
Keyword(s):  
Hyaluronic Acid ◽  
Botulinum Toxin ◽  
Soft Tissue ◽  
Doppler Ultrasound ◽  
Vascular Complications ◽  
Level Of Evidence ◽  
Filler Injection ◽  
Subcutaneous Layer ◽  
Soft Tissue Filler

Abstract Background Glabellar wrinkle corrections are usually performed by injecting botulinum toxin and hyaluronic acid fillers. The glabella is one of the most dangerous locations for filler injection because of possible visual complications. Objectives The aim of this study was to use Doppler ultrasound to determine the anatomic relation between glabellar wrinkles and the supratrochlear artery pathway, perform safe hyaluronic acid filler injection to correct glabellar wrinkles, and determine the efficacy of the procedure. Methods From January 2019 to July 2019, 42 patients (74 glabellar wrinkle lines; 32 bilateral and 10 unilateral wrinkles) were evaluated. Glabellar wrinkle lines were corrected with hyaluronic acid filler. Doppler ultrasound was used to avoid the supratrochlear artery. Results Among the 74 wrinkle lines, the supratrochlear arteries were located either at the glabellar wrinkle lines (30/74, 41%) or lateral to the glabellar wrinkle lines (44/74, 59%). In the latter 44 wrinkles, fillers were injected into the subdermal layer of the glabellar wrinkle lines. In the 30 wrinkles where supratrochlear artery was located at the glabellar wrinkle lines, the artery was located at the deep subcutaneous layer in 24 and at the subdermal layer in 6; thus, filler injection was not performed. Conclusions The supratrochlear artery may be located either at or lateral to the glabellar wrinkle lines. When performing glabellar wrinkle correction, Doppler ultrasound can be used to confirm the location of the supratrochlear artery before filler injection, which helps in avoiding vascular complications. Level of Evidence: 4

COLLAGEN COUPLED WITH HYALURONIC: SYNTHESIS AND SOFT TISSUE FILLER APPLICATION

2010 ◽  
Vol 22 (05) ◽  
pp. 401-407 ◽  
Author(s):  
Kwang Yi Tung ◽  
Ming Wei Lee
Keyword(s):  
Soft Tissue ◽  
Collagen Fibril ◽  
Biomedical Applications ◽  
Collagen Fibrils ◽  
Migration Ability ◽  
Soft Tissue Filler ◽  
Modification Rate ◽  
Injectable Filler

Injectable filler, which is often applied in minimally invasive surgery, has been widely-used in facial rejuvenation. Because of its convenience, effective usage and less downtime after treatment for the patients, it becomes one of the most popular treatment methods at present. The currently available products containing collagen base have been proven to have much satisfactory safety and effectiveness, but one of its disadvantages is the lack of long-term volume persistence. We have previously prepared the reconstituted collagen fibrils with hyaluronic acid (HA) by modifying the fibril surface. This study is to evaluate the potential of these materials as injectable filler in vitro. A preparation of collagen fibrils with a diameter of 100–150 nm was used. The modification rate of HA on the fibril surface was 20%. In assessment of the biocompatibility, it was proven that the collagen fibril and HA-collagen fibril treated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) had no cytotoxicity or inhibitory actions. In interactions between these materials and cells, it was found that the existence of HA could improve the migration ability of L929 fibroblasts and breast cancer cells (MDA-MB 435s). In conclusion, collagen fibril and HA-collagen fibril have the potential to be developed into an injection as a soft tissue filler for biomedical applications.

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