Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double-blind, and placebo-controlled study

2017 ◽  
Vol 16 (4) ◽  
pp. 512-519 ◽  
Author(s):  
Do Un Kim ◽  
Hee Chul Chung ◽  
Changhee Kim ◽  
Jae-Kwan Hwang
Keyword(s):  
Oral Intake ◽  
Skin Hydration ◽  
Controlled Study ◽  
Double Blind

scholarly journals Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1671
Author(s):  
Masumi Nagae ◽  
Maki Nagata ◽  
Mitsuhiro Teramoto ◽  
Masayuki Yamakawa ◽  
Takahiro Matsuki ◽  
...  
Keyword(s):  
Winter Season ◽  
Oral Intake ◽  
Skin Condition ◽  
Quality Parameters ◽  
Controlled Study ◽  
Adult Women ◽  
Health Food ◽  
Food Ingredient ◽  
Double Blind ◽  
Skin Quality

Placenta extract has been used as a component of ointments for skin dryness and beautification. However, little is known about the effect of oral intake of placenta extract on skin condition. The current study aimed to clinically explore the effect of oral intake of porcine placenta extract on human skin quality. A randomized controlled double-blind trial was performed on healthy women aged 40–59 years (n = 20), who were randomly assigned to receive either placebo or 200 mg of porcine placenta extract once daily for 4 weeks from 28 January 2019 to 25 February 2019. Skin quality parameters and the Simplified Menopausal Index (SMI) were assessed at baseline and after 4 weeks. After 4 weeks, three parameters of skin quality were significantly improved in the porcine placenta group compared with the placebo group. These results suggest that porcine placenta extract can be used as a health food ingredient to maintain humans’ skin condition in the dry winter season.

Chronic, But Not Acute, Oral L-Arginine Supplementation Attenuates Exercise-Induced Ammonia Accumulation in Healthy Young Men: A Randomised, Double-Blind, Cross-Over, Placebo-Controlled Trial

2021 ◽  
Author(s):  
Ayano Hiratsu ◽  
Yusei Tataka ◽  
Saki Namura ◽  
Chihiro Nagayama ◽  
Yuka Hamada ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Effect Size ◽  
Performance Test ◽  
Young Men ◽  
Oral Intake ◽  
Cycling Performance ◽  
Controlled Study ◽  
Double Blind ◽  
Ammonia Accumulation ◽  
Arginine Supplementation

Abstract Background This study examined the effects of a single and continuous oral intake of L-arginine supplementation on blood metabolites and exercise performance. Methods Sixteen healthy young men (mean ± standard deviation, 23 ± 3 years) participated in a randomised, double-blind, cross-over, placebo-controlled study. For the acute trials, the participants consumed 200 mL of water containing either L-arginine (5 g) or placebo (L-arginine was replaced with dextrin) and performed cycling exercise at 75 % of heart rate reserve for 60 min, followed by a 15-min cycling performance test. The participants continued to consume each designated supplement twice a day for 13 days. For the chronic trials, the participants repeated the same protocol as the acute trials at day 15. After a 14-day washout period, the participants changed the supplement and repeated the same protocol as above. The linear mixed model was used to examine between-trial differences over the 1-day or 2-week intervention for outcome variables. Results Plasma ammonia concentrations were lower in the chronic arginine (43.5 ± 27.6 µmol/L) trial than in both acute arginine (52.1 ± 36.3 µmol/L, 95% confidence interval − 15.907 to − 1.318 µmol/L, Effect size = 0.262) and placebo (51.1 ± 32.7 µmol/L, 95% confidence interval − 14.932 to − 0.343 µmol/L, Effect size = 0.249) trials (p < 0.05). No differences were found in mean power output during the performance test between the chronic arginine (169.3 ± 8.6 W) and placebo (168.8 ± 2.3 W) trials (p > 0.05). Conclusions These results indicate that a continuous oral intake of L-arginine supplementation attenuated ammonia accumulation, but this did not influence cycling performance.

scholarly journals Clinical effectiveness of the sequential 4-channel NMES compared with that of the conventional 2-channel NMES for the treatment of dysphagia in a prospective double-blind randomized controlled study

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Kyoung-Ho Seo ◽  
Joonyoung Jang ◽  
Eun Gyeong Jang ◽  
Yulhyun Park ◽  
So Young Lee ◽  
...  
Keyword(s):  
Neuromuscular Electrical Stimulation ◽  
Oral Intake ◽  
Clinical Effectiveness ◽  
Controlled Study ◽  
Double Blind ◽  
Registration Number ◽  
Md Anderson ◽  
Functional Oral Intake Scale ◽  
Anderson Dysphagia Inventory

Abstract Background To date, conventional swallowing therapies and 2-channel neuromuscular electrical stimulation (NMES) are standard treatments for dysphagia. The precise mechanism of 2-channel NMES treatment has not been determined, and there are controversies regarding the efficacy of this therapy. The sequential 4-channel NMES was recently developed and its action is based on the normal contractile sequence of swallowing-related muscles. Objective To evaluate and compare the rehabilitative effectiveness of the sequential 4-channel NMES with that of conventional 2-channel NMES. Methods In this prospective randomized case–control study, 26 subjects with dysphagia were enrolled. All participants received 2- or 4-channel NMES for 2–3 weeks (minimal session: 7 times, treatment duration: 300–800 min). Twelve subjects in the 4-channel NMES group and eleven subjects in the 2-channel NMES group completed the intervention. Initial and follow-up evaluations were performed using the videofluoroscopic dysphagia scale (VDS), the penetration-aspiration scale (PAS), the MD Anderson dysphagia inventory (MDADI), the functional oral intake scale (FOIS), and the Likert scale. Results The sequential 4-channel NMES group experienced significant improvement in their VDS (oral, pharyngeal, and total), PAS, FOIS, and MDADI (emotional, functional, and physical subsets) scores, based on their pretreatment data. VDS (oral, pharyngeal, and total) and MDADI (emotional and physical subsets) scores, but not PAS and FOIS scores, significantly improved in the 2-channel NMES group posttreatment. When the two groups were directly compared, the 4-channel NMES group showed significant improvement in oral and total VDS scores. Conclusions The sequential 4-channel NMES, through its activation of the suprahyoid and thyrohyoid muscles, and other infrahyoid muscles mimicking physiological activation, may be a new effective treatment for dysphagia. Trial registration: clinicaltrial.gov, registration number: NCT03670498, registered 13 September 2018, https://clinicaltrials.gov/ct2/show/NCT03670498?term=NCT03670498&draw=2&rank=1.

scholarly journals Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

2016 ◽  
Vol 12 (6) ◽  
pp. 3863-3872 ◽  
Author(s):  
Masahiro Ogawa ◽  
Asako Saiki ◽  
Yuuta Matsui ◽  
Norihiko Tsuchimoto ◽  
Yasukazu Nakakita ◽  
...  
Keyword(s):  
Oral Intake ◽  
Lactobacillus Brevis ◽  
Controlled Study ◽  
Dry Skin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Skin Conditions

scholarly journals Oral intake of heat-killed cells of Lactococcus lactis strain H61 promotes skin health in women

2012 ◽  
Vol 1 ◽  
Author(s):  
Hiromi Kimoto-Nira ◽  
Reiji Aoki ◽  
Keisuke Sasaki ◽  
Chise Suzuki ◽  
Koko Mizumachi
Keyword(s):  
Placebo Group ◽  
Environmental Change ◽  
Lactococcus Lactis ◽  
Controlled Trial ◽  
Oral Intake ◽  
Hair Follicles ◽  
Skin Hydration ◽  
Ageing Population ◽  
Skin Elasticity ◽  
Double Blind

AbstractWe conducted a double-blind, placebo-controlled trial to evaluate the effect of heat-killed cells of Lactococcus lactis strain H61 on various skin properties of Japanese women. Volunteers (age 31–62 years) were randomly assigned to receive test food with or without 60 mg of heat-killed strain H61 (fifteen women in each group; H61 and control groups, respectively) daily for 8 weeks. Results were analysed for three age categories (30s, 40s and 50–60s). Compared with that at week 0, skin hydration at the inner forearm at weeks 4 and 8 decreased in all volunteers (except those in their 50–60s) because of the environmental change from autumn to winter. The oldest H61 group maintained skin hydration at the inner forearm throughout the study. Skin elasticity and melanin content in the cheek decreased and sebum content increased throughout the test period due to seasonal environmental change, regardless of age or H61 treatment. Self-evaluation scores for apparent hair follicles and dryness of the throat at week 8 were higher in the overall H61 group than in the combined placebo group. The 30s H61 group noted marked improvements in self-surveyed skin elasticity at week 8 compared with at week 0 and with the placebo group at week 8. The results of the present study indicate that oral intake of heat-killed cells of L. lactis strain H61 can improve some skin properties and body characteristics in women. This strain would probably be useful in increasing the quality of life in an ageing population.

scholarly journals Effectiveness of the sequential 4-channel NMES compared with conventional 2-channel NMES for the treatment of dysphagia in a prospective double-blind randomized controlled study

2020 ◽  
Author(s):  
Kyoung-Ho Seo ◽  
Joonyoung Jang ◽  
Eun Gyeong Jang ◽  
Yulhyun Park ◽  
So Young Lee ◽  
...  
Keyword(s):  
Neuromuscular Electrical Stimulation ◽  
Oral Intake ◽  
Controlled Study ◽  
Double Blind ◽  
Physical Scale ◽  
Registration Number ◽  
Md Anderson ◽  
Functional Oral Intake Scale ◽  
Anderson Dysphagia Inventory ◽  
Control Study

Abstract Background: To date, conventional swallowing therapies and 2-channel NMES are standard treatments for dysphagia. The precise mechanism of 2-channel neuromuscular electrical stimulation (NMES) treatment has yet to be determined, and controversy remains over the efficacy. The sequential 4-channel NMES was newly developed based on the normal contractile sequence of swallowing-related muscles. Objective: To evaluate and compare the rehabilitative effectiveness of sequential 4-channel NMES with that of conventional 2-channel NMES.Methods: In this prospective randomized case-control study, 23 subjects with dysphagia were enrolled. Twelve subjects with 4-channel NMES group and eleven subjects with 2-channel NMES group completed the intervention. Pretreatment and posttreatment evaluations were performed with the videofluoroscopic dysphagia scale (VDS), penetration-aspiration scale (PAS), MD Anderson dysphagia inventory (MDADI), functional oral intake scale (FOIS), and Likert scale.Results: The sequential 4-channel NMES group significantly improved the VDS (oral, pharyngeal, and total), PAS, FOIS, and MDADI (emotional, functional, and physical scale) compared with pretreatment data. The 2-channel NMES group significantly improved the VDS (oral, pharyngeal, and total) and MDADI (emotional, physical scale), but not the PAS and FOIS compared with pretreatment data. When the two groups were directly compared, the 4-channel NMES group showed significant improvement in oral and total VDS.Conclusions: Sequential 4-channel NMES activating the suprahyoid, thyrohyoid, and other infrahyoid muscles with proper interval time can be a new effective treatment for dysphagia.Trial registration : clinicaltrial.gov, registration number: NCT03670498, registered 13 September 2018, https://clinicaltrials.gov/ct2/show/NCT03670498?term=NCT03670498&draw=2&rank=1

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