Id(entifying) the inhibitor of DNA binding 3 in the brain of Nothobranchius furzeri upon aging

2020 ◽  
Author(s):  
Adele Leggieri ◽  
Antonio Palladino ◽  
Chiara Attanasio ◽  
Luigi Avallone ◽  
Paolo Girolamo ◽  
...  
Keyword(s):  
Dna Binding ◽  
Nothobranchius Furzeri ◽  
Inhibitor Of Dna Binding ◽  
The Brain

scholarly journals Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Taegwan Yun ◽  
Hyo Rim Ko ◽  
Dong-Kyu Jo ◽  
Kye Won Park ◽  
Sung-Woo Cho ◽  
...  
Keyword(s):  
Dna Binding ◽  
Neural Development ◽  
Neuronal Development ◽  
Axon Growth ◽  
Microtubule Polymerization ◽  
Mice Brain ◽  
Low Levels ◽  
And Function ◽  
Inhibitor Of Dna Binding ◽  
The Brain

AbstractAcetylation of α-tubulin lysine 40 (αK40) contributes to microtubule (MT) stability and is essential for neuronal development and function, whereas excessive αK40 deacetylation is observed in neurodegenerative disorders including Alzheimer’s disease (AD). Here we identified inhibitor of DNA binding 2 (Id2) as a novel MT-binding partner that interacts with α-tubulin and enhances αK40 acetylation, leading to MT polymerization in the neurons. Commensurate with our finding that the low levels of Id2 expression along with a reduced αK40 acetylation in the postmortem human AD patient and 5X-FAD, AD model mice brain, Id2 upregulation in the hippocampus of 5X-FAD, which exhibit high levels of Sirt2 expression, increased αK40 acetylation and reconstitutes axon growth. Hence our study suggests that Id2 is critical for maintaining MT stability during neural development and the potential of Id2 to counteract pathogenic Sirt2 activity in AD.

Neurotrophin Trk receptors in the brain of a teleost fish, Nothobranchius furzeri

2012 ◽  
Vol 75 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Livia D'Angelo ◽  
Paolo de Girolamo ◽  
Alessandro Cellerino ◽  
Eva Terzibasi Tozzini ◽  
Luciana Castaldo ◽  
...  
Keyword(s):  
Teleost Fish ◽  
Trk Receptors ◽  
Nothobranchius Furzeri ◽  
The Brain

Uranyl Acetate as a Direct Inhibitor of DNA-Binding Proteins

2007 ◽  
Vol 20 (5) ◽  
pp. 784-789 ◽  
Author(s):  
Wendy J. Hartsock ◽  
Jennifer D. Cohen ◽  
David J. Segal
Keyword(s):  
Dna Binding ◽  
Binding Proteins ◽  
Dna Binding Proteins ◽  
Uranyl Acetate ◽  
Inhibitor Of Dna Binding

Inhibitor of DNA Binding 4 (ID4)

2012 ◽  
pp. 926-930
Author(s):  
Kathryn M. Appleton ◽  
Ian Cushman ◽  
Yuri K. Peterson ◽  
Balachandran Manavalan ◽  
Shaherin Basith ◽  
...  
Keyword(s):  
Dna Binding ◽  
Inhibitor Of Dna Binding

scholarly journals Curcumin Inhibits Expression of Inhibitor of DNA Binding 1 in PC3 Cells and Xenografts

2014 ◽  
Vol 15 (3) ◽  
pp. 1465-1470 ◽  
Author(s):  
Xiao-Ling Yu ◽  
Tao Jing ◽  
Hui Zhao ◽  
Pei-Jie Li ◽  
Wen-Hua Xu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Pc3 Cells ◽  
Inhibitor Of Dna Binding

scholarly journals Inhibitor of DNA binding in heart development and cardiovascular diseases

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Wenyu Hu ◽  
Yanguo Xin ◽  
Jian Hu ◽  
Yingxian Sun ◽  
Yinan Zhao
Keyword(s):  
Cardiovascular Diseases ◽  
Dna Binding ◽  
Heart Development ◽  
Inhibitor Of Dna Binding

scholarly journals Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2021 ◽  
Author(s):  
Chi-Chung Wang ◽  
Yuan-Ling Hsu ◽  
Chi-Jen Chang ◽  
Chia-Jen Wang ◽  
Tzu-Hung Hsiao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Binding ◽  
Lung Adenocarcinoma ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Inhibitor Of Dna Binding ◽  
E Cadherin

Metastasis is a predominant cause of cancer death and the major challenge in treating lung adenocarcinoma (LADC). Therefore, exploring new metastasis-related genes and their action mechanisms may provide new insights for developing a new combative approach to treat lung cancer. Previously, our research team discovered that the expression of the inhibitor of DNA binding 4 (Id4) was inversely related to cell invasiveness in LADC cells by cDNA microarray screening. However, the functional role of Id4 and its mechanism of action in lung cancer metastasis remain unclear. In this study, we report that the expression of Id4 could attenuate cell migration and invasion in vitro and cancer metastasis in vivo. Detailed analyses indicated that Id4 could promote E-cadherin expression through the binding of Slug, cause the occurrence of mesenchymal-epithelial transition (MET), and inhibit cancer metastasis. Moreover, the examination of the gene expression database (GSE31210) also revealed that high-level expression of Id4/E-cadherin and low-level expression of Slug were associated with a better clinical outcome in LADC patients. In summary, Id4 may act as a metastatic suppressor, which could not only be used as an independent predictor but also serve as a potential therapeutic for LADC treatment.

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