Neurotrophin Trk receptors in the brain of a teleost fish, Nothobranchius furzeri

2012 ◽  
Vol 75 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Livia D'Angelo ◽  
Paolo de Girolamo ◽  
Alessandro Cellerino ◽  
Eva Terzibasi Tozzini ◽  
Luciana Castaldo ◽  
...  
Keyword(s):  
Teleost Fish ◽  
Trk Receptors ◽  
Nothobranchius Furzeri ◽  
The Brain

Relationships between aromatase and estrogen receptors in the brain of teleost fish

2005 ◽  
Vol 142 (1-2) ◽  
pp. 60-66 ◽  
Author(s):  
Elisabeth Pellegrini ◽  
Arnaud Menuet ◽  
Christèle Lethimonier ◽  
Fátima Adrio ◽  
Marie-Madeleine Gueguen ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Teleost Fish ◽  
The Brain

Rapid acclimation of the cortisol stress response in adult turquoise killifish Nothobranchius furzeri

2018 ◽  
Vol 53 (4) ◽  
pp. 383-393
Author(s):  
Dallas W Henderson ◽  
Brian C Small
Keyword(s):  
Messenger Rna ◽  
Plasma Cortisol ◽  
Constitutive Expression ◽  
Whole Body ◽  
Stress Axis ◽  
Model Species ◽  
Repeated Stress ◽  
Nothobranchius Furzeri ◽  
The Brain ◽  
Dimorphic Behavior

The turquoise killifish Nothobranchius furzeri is an increasingly popular model species for comparative vertebrate research, and the basic physiology including responses to stressful stimuli are of primary interest. We exposed adult killifish to a single or repeated periods of acute confinement followed by analysis of tissue cortisol and plasma cortisol concentrations. Individuals were also sampled for messenger RNA (mRNA) expression of corticotropin-releasing hormone ( CRH), mineralocorticoid receptor ( MR), and glucocorticoid receptor ( GR) in the brain to examine the effects of repeated stress events on constitutive expression of these important stress axis components. Following a single 30-minute confinement stress, male plasma cortisol significantly differed from baseline ( p = 0.04). Both male and female whole-body cortisol were significantly increased ( p = 0.004 and p = 0.04, respectively) at 15 and 30 minutes poststress. Despite obvious dimorphic behavior and morphology, cortisol concentrations did not differ between the sexes. Exposure to daily repeated confinement for one week altered the cortisol response in both sexes. Time 0, 15, and 60 minutes poststress cortisol concentrations were depressed in repeatedly stressed males ( p ≤ 0.05), and times 0, 30 and 120 minutes poststress cortisol concentrations were depressed in repeatedly stressed females ( p ≤ 0.05). Constitutive expression of CRH, MR, and GR mRNA in the brain following one week of repeated stress events did not differ among treatments or sexes. This study introduces the first description of hypothalamic-pituitary-interrenal axis activity in this important model species. Reduced cortisol production in repeatedly stressed adult killifish suggests acclimation to repeated stressors. Furthermore, acclimation was rapid, and plasma cortisol concentrations altered significantly in as little as one week.

Id(entifying) the inhibitor of DNA binding 3 in the brain of Nothobranchius furzeri upon aging

2020 ◽  
Author(s):  
Adele Leggieri ◽  
Antonio Palladino ◽  
Chiara Attanasio ◽  
Luigi Avallone ◽  
Paolo Girolamo ◽  
...  
Keyword(s):  
Dna Binding ◽  
Nothobranchius Furzeri ◽  
Inhibitor Of Dna Binding ◽  
The Brain

scholarly journals Actions of sex steroids on kisspeptin expression and other reproduction-related genes in the brain of the teleost fish European sea bass

2016 ◽  
Vol 219 (21) ◽  
pp. 3353-3365 ◽  
Author(s):  
M. V. Alvarado ◽  
A. Servili ◽  
G. Molés ◽  
M. M. Gueguen ◽  
M. Carrillo ◽  
...  
Keyword(s):  
Sex Steroids ◽  
Teleost Fish ◽  
Sea Bass ◽  
European Sea Bass ◽  
The Brain

scholarly journals Identification and Expression of Neurotrophin-6 in the Brain of Nothobranchius furzeri: One More Piece in Neurotrophin Research

2019 ◽  
Vol 8 (5) ◽  
pp. 595 ◽  
Author(s):  
Leggieri ◽  
Attanasio ◽  
Palladino ◽  
Cellerino ◽  
Lucini ◽  
...  
Keyword(s):  
Adult Brain ◽  
Locked Nucleic Acid ◽  
Age Related ◽  
Gene Coding ◽  
Nothobranchius Furzeri ◽  
History Of ◽  
Mature Neurons ◽  
Significant Expression ◽  
First Time ◽  
The Brain

Neurotrophins contribute to the complexity of vertebrate nervous system, being involved in cognition and memory. Abnormalities associated with neurotrophin synthesis may lead to neuropathies, neurodegenerative disorders and age-associated cognitive decline. The genome of teleost fishes contains homologs of some mammalian neurotrophins as well as a gene coding for an additional neurotrophin (NT-6). In this study, we characterized this specific neurotrophin in the short-lived fish Nothobranchius furzeri, a relatively new model for aging studies. Thus, we report herein for the first time the age-related expression of a neurotrophin in a non-mammalian vertebrate. Interestingly, we found comparable expression levels of NT-6 in the brain of both young and old animals. More in detail, we used a locked nucleic acid probe and a riboprobe to investigate the neuroanatomical distribution of NT-6 mRNA revealing a significant expression of the neurotrophin in neurons of the forebrain (olfactory bulbs, dorsal and ventral telencephalon, and several diencephalic nuclei), midbrain (optic tectum, longitudinal tori, and semicircular tori), and hindbrain (valvula and body of cerebellum, reticular formation and octavolateral area of medulla oblongata). By combining in situ hybridization and immunohistochemistry, we showed that NT-6 mRNA is synthesized in mature neurons. These results contribute to better understanding the evolutionary history of neurotrophins in vertebrates, and their role in the adult brain.

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