Different patterns in age‐related morphometric alteration of myelinated fibers and capillaries of the tibial nerve: a longitudinal study in normal rats

2020 ◽  
Vol 236 (6) ◽  
pp. 1101-1111
Author(s):  
Masahiro Sakita ◽  
Shinichiro Murakami ◽  
Koji Nonaka ◽  
Ryuji Sakamoto ◽  
Takafumi Saito ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Tibial Nerve ◽  
Myelinated Fibers ◽  
Age Related

scholarly journals Longitudinal Study of Visual Function in Dry Age-Related Macular Degeneration at 12 Months

2019 ◽  
Vol 3 (8) ◽  
pp. 637-648 ◽  
Author(s):  
S. Tammy Hsu ◽  
Atalie C. Thompson ◽  
Sandra S. Stinnett ◽  
Ulrich F.O. Luhmann ◽  
Lejla Vajzovic ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Macular Degeneration ◽  
Visual Function ◽  
Age Related Macular Degeneration ◽  
Age Related

IC-P-100: Cross-Sectional and Longitudinal Study of Age-Related Shrinkage in the Superior,Middle and Inferior Frontal Gyrus in Old and Very Old Age

2010 ◽  
Vol 6 ◽  
pp. S40-S40
Author(s):  
Olof E. Lindberg ◽  
Carl-Henrik Ehrenkrona ◽  
Linnea Engström ◽  
Leif A. Svensson ◽  
Eva Öhrndahl ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Old Age ◽  
Inferior Frontal Gyrus ◽  
Cross Sectional ◽  
Very Old ◽  
Age Related ◽  
Very Old Age

Bidirectional Association Between Depression and Hearing Loss: Evidence From the China Health and Retirement Longitudinal Study

2021 ◽  
pp. 073346482110423
Author(s):  
Chao Wu
Keyword(s):  
Hearing Loss ◽  
Longitudinal Study ◽  
Cognitive Decline ◽  
Age Related ◽  
Bidirectional Association ◽  
Health Related ◽  
Clinically Significant ◽  
Using Data ◽  
Bidirectional Associations ◽  
Age Related Hearing Loss

The relationship between depression and age-related hearing loss (ARHL) is not fully understood. This study tested the bidirectional associations between clinically significant depressive symptoms (CSDSs) and ARHL in middle-aged and older adults using data from the China Health and Retirement Longitudinal Study. Among 3,418 participants free of baseline ARHL, baseline CSDS was associated with an increased odds of incident ARHL (odds ratio [OR]: 1.51). Cognitive decline, BMI, and arthritis partially mediated the longitudinal CSDS–ARHL association and explained 24% of the variance in the total effect. Among 4,921 participants without baseline CSDS, baseline ARHL was associated with an increased odds of incident CSDS (OR: 1.37). The bidirectional associations remained significant after adjustments for baseline demographic factors, comorbidities, and other health-related covariates. Depression may contribute to the development of ARHL, and vice versa. Interventions in depression, cognitive decline, and arthritis may delay the onset of ARHL and break the vicious circle between them.

scholarly journals Sex-differences in age-related grip strength decline: A 10-year longitudinal study of community-living middle-aged and older Japanese

2016 ◽  
Vol 5 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Rumi Kozakai ◽  
Fujiko Ando ◽  
Heung Youl Kim ◽  
Atsumu Yuki ◽  
Rei Otsuka ◽  
...  
Keyword(s):  
Sex Differences ◽  
Longitudinal Study ◽  
Grip Strength ◽  
Community Living ◽  
Middle Aged ◽  
Age Related

scholarly journals Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

2021 ◽  
Vol 13 ◽  
Author(s):  
Pei-Lun Kuo ◽  
Ann Zenobia Moore ◽  
Frank R. Lin ◽  
Luigi Ferrucci
Keyword(s):  
Dna Methylation ◽  
Longitudinal Study ◽  
Smoking History ◽  
Future Research ◽  
Age Related ◽  
Epigenetic Age ◽  
Epigenetic Age Acceleration ◽  
Baltimore Longitudinal Study ◽  
Age Related Hearing Loss ◽  
The Relationship

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated diseases and mortality. However, the association between epigenetic age acceleration and hearing remains unknown. Our study aims to investigate the relationship between epigenetic age acceleration and audiometric hearing in the Baltimore Longitudinal Study of Aging (BLSA).Methods: Participants with both DNA methylation and audiometric hearing measurements were included. The main independent variables are epigenetic age acceleration measures, including intrinsic epigenetic age acceleration—“IEAA,” Hannum age acceleration—“AgeAccelerationResidualHannum,” PhenoAge acceleration—“AgeAccelPheno,” GrimAge acceleration—“AgeAccelGrim,” and methylation-based pace of aging estimation—“DunedinPoAm.” The main dependent variable is speech-frequency pure tone average. Linear regression was used to assess the association between epigenetic age acceleration and hearing.Results: Among the 236 participants (52.5% female), after adjusting for age, sex, race, time difference between measurements, cardiovascular factors, and smoking history, the effect sizes were 0.11 995% CI: (–0.00, 0.23), p = 0.054] for Hannum’s clock, 0.08 [95% CI: (–0.03, 0.19), p = 0.143] for Horvath’s clock, 0.10 [95% CI: (–0.01, 0.21), p = 0.089] for PhenoAge, 0.20 [95% CI: (0.06, 0.33), p = 0.004] for GrimAge, and 0.21 [95% CI: (0.09, 0.33), p = 0.001] for DunedinPoAm.Discussion: The present study suggests that some epigenetic age acceleration measurements are associated with hearing. Future research is needed to study the potential subclinical cardiovascular causes of hearing and to investigate the longitudinal relationship between DNA methylation and hearing.

scholarly journals Do social factors mediate or moderate the sensory-cognitive associations in older adults in the Canadian Longitudinal Study on Aging?

2019 ◽  
Author(s):  
Anni Hämäläinen ◽  
Natalie Phillips ◽  
Walter Wittich ◽  
Paul Mick ◽  
M Kathleen Pichora-Fuller
Keyword(s):  
Longitudinal Study ◽  
Cognitive Decline ◽  
Social Factors ◽  
Pure Tone Audiometry ◽  
Sensory Function ◽  
Sensory Loss ◽  
Protective Effects ◽  
Social Variables ◽  
Cross Sectional ◽  
Age Related

Sensory and cognitive function both tend to decline with increasing age. Sensory impairments are risk factors for age-related cognitive decline and dementia. One hypothesis about sensory-cognitive associations is that sensory loss results in social isolation which, in turn, is a risk factor for cognitive decline. We tested whether social factors are associated with cognitive and sensory function, and whether sensory-cognitive associations are mediated or moderated by social factors. We used cross-sectional data from 30,029 participants in the Canadian Longitudinal Study of Aging, aged 45-85 years, who had no reported cognitive impairment or diagnosis of dementia. We found strong independent associations of self-reported social variables with hearing (pure-tone audiometry), vision (pinhole-corrected visual acuity), and executive function and weaker associations with memory. The moderating and mediating effects of social variables on sensory-cognitive associations were weak and mostly non-significant, but social factors could be slightly more important for females and older people. Partial retirement (relative to full retirement or not being retired) may have protective effects on cognition in the presence of hearing loss. These findings confirm the association between social factors and sensory and cognitive measures. However, support is weak for the hypothesis that social factors shape sensory-cognitive associations.

Age-related changes in immune parameters in a very old population of Swedish people: A longitudinal study

1994 ◽  
Vol 29 (5) ◽  
pp. 531-541 ◽  
Author(s):  
Anders Wikby ◽  
Boo Johansson ◽  
Frederick Ferguson ◽  
Jadwiga Olsson
Keyword(s):  
Longitudinal Study ◽  
Very Old ◽  
Immune Parameters ◽  
Age Related ◽  
Age Related Changes

scholarly journals INFLUENCING FACTORS OF SUBJECTIVE AGE: FINDINGS FROM THE KUSATSU LONGITUDINAL STUDY ON AGING AND HEALTH

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S695-S696
Author(s):  
Tomoko Ikeuchi ◽  
Satoshi Seino ◽  
Yu Taniguchi ◽  
Miki Narita ◽  
Takumi Abe ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Cognitive Function ◽  
Influencing Factors ◽  
Community Dwelling ◽  
Chronological Age ◽  
Social Changes ◽  
Subjective Age ◽  
Age Related ◽  
Years Of Schooling

Abstract Background: Subjective age (SA) has been found to be a biopsychosocial marker of aging, yet little is known about factors that influence SA development. This study examined factors influencing SA using longitudinal data of community-dwelling older Japanese. Methods: Data drawn from the Kusatsu Longitudinal Study were collected during annual health check-ups in 2017 and 2018 from participants (aged 65-95) who completed all the measurement items used for this analysis (N=981). SA was indexed by asking participants to specify in years how old they felt. Proportional discrepancy scores ((subjective age - chronological age)/chronological age ×100) were calculated to indicate younger or older SAs and used as a dependent variable. As influencing factors of SA, chronological age, sex, years of schooling, history of smoking, cognitive function (using MMSE scores, range 14-30 at baseline), depressive symptoms, physical function (gait speed), and social function (employment status) were examined. Analyses were performed with random-effects GLS regression models. Results: Significant partial regression coefficients were found for cognitive function (0.48%, CI: 0.18, 0.79), years of schooling (-0.42%, CI: -0.69, -0.15), depressive symptoms (0.32%, CI: 0.11, 0.53), and chronological age (-0.18%, CI: -0.30, -0.68). Implications: This study found that older age and longer years of schooling were associated with younger SA, while better cognition and depressive symptoms were linked to older SA. Better cognition being associated with older SA was inconsistent with existing studies. This may be due in part to the association of better cognition and the level of satisfaction influenced by awareness of age-related physical/social changes.

Current Status of the Neurobiology of Alzheimer's Disease and the Importance of Early Diagnosis

2002 ◽  
Vol 8 (4) ◽  
pp. 596-597
Author(s):  
Edith V. Sullivan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Early Diagnosis ◽  
Medical Treatment ◽  
Accurate Diagnosis ◽  
Current Status ◽  
Age Related ◽  
Loss Of Dignity ◽  
Scientific Rationale

Alzheimer's disease—occurring upward of 15% of individuals age 65 and older—is the most prevalent age-related dementia. Since the late 1970s, neuropsychologists have been instrumental in identifying patterns of sparing and impairment of cognitive, sensory, and motor functions and rates of declines in selective functions. Anyone who has engaged in longitudinal study of AD and anyone of that large segment of the population with relatives suffering with AD has witnessed first-hand the relentless, irreversible demise of function and ultimate loss of dignity characteristic of AD's course. The approach of Scinto and Daffner's edited book, Early Diagnosis of Alzheimer's Disease, avoids rehashing the already established descriptions of AD and provides firm, scientific rationale for the meaningfulness of early and accurate diagnosis of AD despite its current dire prognosis and lack of effective medical treatment.

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