scholarly journals Adaptive self-organization in the embryo: its importance to adult anatomy and to tissue engineering

2017 ◽  
Vol 232 (4) ◽  
pp. 524-533
Author(s):  
Jamie A. Davies
2002 ◽  
Vol 724 ◽  
Author(s):  
Sarah Calve ◽  
Ellen Arruda ◽  
Robert Dennis ◽  
Karl Grosh ◽  
Krystyna Pasyk

AbstractThe creation of an in vitro functional tendon construct will enable testing of the influence of mechanics and nutrients on the development and remodeling of tendon under known controlled stimuli which is difficult to achieve in vivo. Tendon constructs were engineered in vitrovia stress-mediated self organization of fibroblasts and ECM on a laminin coated elastomer substrate. Varying the laminin density and the amount of fetal bovine serum on the substrate affected the ability of tendon fibroblasts to form a confluent cell layer and the time to layer delamination. Understanding the factors that promote self-assembly of tendon constructs will enable their combination with already developed in vitro muscle constructs.


2013 ◽  
Vol 15 (1) ◽  
pp. 115-136 ◽  
Author(s):  
Kyriacos A. Athanasiou ◽  
Rajalakshmanan Eswaramoorthy ◽  
Pasha Hadidi ◽  
Jerry C. Hu

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