Corneal confocal microscopy detects small fiber damage in chronic inflammatory demyelinating polyneuropathy (CIDP)

2014 ◽  
Vol 19 (4) ◽  
pp. 322-327 ◽  
Author(s):  
Christian Schneider ◽  
Franziska Bucher ◽  
Claus Cursiefen ◽  
Gereon R. Fink ◽  
Ludwig M. Heindl ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Demyelinating Polyneuropathy ◽  
Fiber Damage ◽  
Small Fiber ◽  
Corneal Confocal Microscopy ◽  
Inflammatory Demyelinating Polyneuropathy

scholarly journals Corneal Confocal Microscopy in the Diagnosis of Small Fiber Neuropathy: Faster, Easier, and More Efficient Than Skin Biopsy?

2021 ◽  
Vol 29 (1) ◽  
pp. 1-8
Author(s):  
Mariia V. Lukashenko ◽  
Natalia Y. Gavrilova ◽  
Anna V. Bregovskaya ◽  
Lidiia A. Soprun ◽  
Leonid P. Churilov ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Skin Biopsy ◽  
Nerve Fiber ◽  
Small Fiber Neuropathy ◽  
Fiber Damage ◽  
Advantages And Disadvantages ◽  
Small Fiber ◽  
Corneal Confocal Microscopy ◽  
Common Causes ◽  
Small Nerve

Chronic pain may affect 30–50% of the world’s population and an important cause is small fiber neuropathy (SFN). Recent research suggests that autoimmune diseases may be one of the most common causes of small nerve fiber damage. There is low awareness of SFN among patients and clinicians and it is difficult to diagnose as routine electrophysiological methods only detect large fiber abnormalities, and specialized small fiber tests, like skin biopsy and quantitative sensory testing, are not routinely available. Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible method for quantifying small nerve fiber degeneration and regeneration, and could be an important tool for diagnosing SFN. This review considers the advantages and disadvantages of CCM and highlights the evolution of this technique from a research tool to a diagnostic test for small fiber damage, which can be a valuable contribution to the study and management of autoimmune disease.

scholarly journals Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeremias Motte ◽  
Thomas Grüter ◽  
Anna Lena Fisse ◽  
Yesim Bulut ◽  
Zornitsa Stykova ◽  
...  
Keyword(s):  
Disease Activity ◽  
Immune Cell ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Demyelinating Polyneuropathy ◽  
Clinical Disease ◽  
Disability Progression ◽  
Clinical Disease Activity ◽  
Potential Marker ◽  
Corneal Confocal Microscopy ◽  
Inflammatory Demyelinating Polyneuropathy

AbstractThe assessment of disease activity is fundamental in the management of chronic inflammatory demyelinating polyneuropathy (CIDP). Previous studies with small patient numbers found an increase of corneal immune cell infiltrates as a potential marker of inflammation in patients with CIDP. However, its clinical relevance remained unclear. The present study aimed to determine whether the amount of corneal inflammatory cells (CIC) measured by corneal confocal microscopy (CCM) detects disease activity in CIDP. CIC were measured in 142 CCM-investigations of 97 CIDP-patients. Data on clinical disease activity, disability (INCAT-ODSS) and need for therapy escalation at the timepoint of CCM, 3 and 6 months later were analyzed depending CIC-count. Pathological spontaneous activity during electromyography was examined as another possible biomarker for disease activity in comparison to CIC-count. An increased CIC-count at baseline was found in patients with clinical disease activity and disability progression in the following 3–6 months. An increase to more than 25 CIC/mm2 had a sensitivity of 0.73 and a specificity of 0.71 to detect clinical disease activity and a sensitivity of 0.77 and a specificity of 0.64 to detect disability progression (increasing INCAT-ODSS) in the following 6 months. An increase to more than 50 CIC/mm2 had a sensitivity of about 0.51 and a specificity of 0.91 to detect clinical disease activity and a sensitivity of 0.53 and a specificity of 0.80 to detect disability progression. CIC count is a non-invasive biomarker for the detection of disease activity in the following 6 months in CIDP.

Electrophysiological and neuromuscular stability of persons with chronic inflammatory demyelinating polyneuropathy

2017 ◽  
Vol 56 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Kevin J. Gilmore ◽  
Matti D. Allen ◽  
Timothy J. Doherty ◽  
Kurt Kimpinski ◽  
Charles L. Rice
Keyword(s):  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Demyelinating Polyneuropathy ◽  
Inflammatory Demyelinating Polyneuropathy
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