scholarly journals Corneal confocal microscopy in chronic inflammatory demyelinating polyneuropathy

2015 ◽  
Vol 3 (2) ◽  
pp. 88-100 ◽  
Author(s):  
Mark Stettner ◽  
Lena Hinrichs ◽  
Rainer Guthoff ◽  
Silja Bairov ◽  
Ioannis N. Petropoulos ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Demyelinating Polyneuropathy ◽  
Corneal Confocal Microscopy ◽  
Inflammatory Demyelinating Polyneuropathy

scholarly journals Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeremias Motte ◽  
Thomas Grüter ◽  
Anna Lena Fisse ◽  
Yesim Bulut ◽  
Zornitsa Stykova ◽  
...  
Keyword(s):  
Disease Activity ◽  
Immune Cell ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Demyelinating Polyneuropathy ◽  
Clinical Disease ◽  
Disability Progression ◽  
Clinical Disease Activity ◽  
Potential Marker ◽  
Corneal Confocal Microscopy ◽  
Inflammatory Demyelinating Polyneuropathy

AbstractThe assessment of disease activity is fundamental in the management of chronic inflammatory demyelinating polyneuropathy (CIDP). Previous studies with small patient numbers found an increase of corneal immune cell infiltrates as a potential marker of inflammation in patients with CIDP. However, its clinical relevance remained unclear. The present study aimed to determine whether the amount of corneal inflammatory cells (CIC) measured by corneal confocal microscopy (CCM) detects disease activity in CIDP. CIC were measured in 142 CCM-investigations of 97 CIDP-patients. Data on clinical disease activity, disability (INCAT-ODSS) and need for therapy escalation at the timepoint of CCM, 3 and 6 months later were analyzed depending CIC-count. Pathological spontaneous activity during electromyography was examined as another possible biomarker for disease activity in comparison to CIC-count. An increased CIC-count at baseline was found in patients with clinical disease activity and disability progression in the following 3–6 months. An increase to more than 25 CIC/mm2 had a sensitivity of 0.73 and a specificity of 0.71 to detect clinical disease activity and a sensitivity of 0.77 and a specificity of 0.64 to detect disability progression (increasing INCAT-ODSS) in the following 6 months. An increase to more than 50 CIC/mm2 had a sensitivity of about 0.51 and a specificity of 0.91 to detect clinical disease activity and a sensitivity of 0.53 and a specificity of 0.80 to detect disability progression. CIC count is a non-invasive biomarker for the detection of disease activity in the following 6 months in CIDP.

Electrophysiological and neuromuscular stability of persons with chronic inflammatory demyelinating polyneuropathy

2017 ◽  
Vol 56 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Kevin J. Gilmore ◽  
Matti D. Allen ◽  
Timothy J. Doherty ◽  
Kurt Kimpinski ◽  
Charles L. Rice
Keyword(s):  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Demyelinating Polyneuropathy ◽  
Inflammatory Demyelinating Polyneuropathy
Sign in / Sign up

Export Citation Format

Share Document