Insulin and endocannabinoids in the mesolimbic system

2021 ◽  
Author(s):  
Nada A. Sallam ◽  
Stephanie L. Borgland
Keyword(s):  
Mesolimbic System

Effects of acute and repeated cocaine on markers for neural plasticity within the mesolimbic system in rats

2014 ◽  
Vol 232 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Nieves Rodriguez-Espinosa ◽  
Emilio Fernandez-Espejo
Keyword(s):  
Neural Plasticity ◽  
Mesolimbic System

Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats

2004 ◽  
Vol 361 (1-3) ◽  
pp. 68-71 ◽  
Author(s):  
Baiba Jansone ◽  
Lena Bergstrom ◽  
Simons Svirskis ◽  
Jonas Lindblom ◽  
Vija Klusa ◽  
...  
Keyword(s):  
Mesolimbic System ◽  
Melanocyte Stimulating Hormone ◽  
Stimulating Hormone

scholarly journals Neuropharmacology of the mesolimbic system and associated circuits on social hierarchies

2019 ◽  
Vol 159 ◽  
pp. 107498 ◽  
Author(s):  
S. Ghosal ◽  
C. Sandi ◽  
M.A. van der Kooij
Keyword(s):  
Social Hierarchies ◽  
Mesolimbic System

Behavioral response elicited by stimulation of the mesolimbic system after procaine and bicuculline injection into the pedunculopontine tegmental nucleus in rats

2013 ◽  
Vol 241 ◽  
pp. 161-172 ◽  
Author(s):  
Grażyna Jerzemowska ◽  
Karolina Plucińska ◽  
Irena Majkutewicz ◽  
Jolanta Orzeł-Gryglewska ◽  
Weronika Trojniar
Keyword(s):  
Behavioral Response ◽  
Pedunculopontine Tegmental Nucleus ◽  
Mesolimbic System ◽  
Tegmental Nucleus ◽  
Stimulation Of

Effect of physical stress on the alteration of mesolimbic system apoptotic factors in conditioned place preference paradigm

2014 ◽  
Vol 124 ◽  
pp. 231-237 ◽  
Author(s):  
Zahra Fatahi ◽  
Shabnam Zeighamy Alamdary ◽  
Fariba Khodagholi ◽  
Shima Zareh Shahamati ◽  
Yasaman Razavi ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Physical Stress ◽  
Place Preference ◽  
Mesolimbic System ◽  
Conditioned Place Preference Paradigm ◽  
Apoptotic Factors

scholarly journals Association between Chronic Pain and Alterations in the Mesolimbic Dopaminergic System

2020 ◽  
Vol 10 (10) ◽  
pp. 701
Author(s):  
Seoyon Yang ◽  
Mathieu Boudier-Revéret ◽  
Yoo Jin Choo ◽  
Min Cheol Chang
Keyword(s):  
Chronic Pain ◽  
Dopaminergic System ◽  
Neural Circuit ◽  
Chronic Back Pain ◽  
Radicular Pain ◽  
Anterior Cingulate ◽  
Mesolimbic System ◽  
Dopaminergic Drugs ◽  
Underlying Mechanisms ◽  
Control Pain

Chronic pain (pain lasting for >3 months) decreases patient quality of life and even occupational abilities. It can be controlled by treatment, but often persists even after management. To properly control pain, its underlying mechanisms must be determined. This review outlines the role of the mesolimbic dopaminergic system in chronic pain. The mesolimbic system, a neural circuit, delivers dopamine from the ventral tegmental area to neural structures such as the nucleus accumbens, prefrontal cortex, anterior cingulate cortex, and amygdala. It controls executive, affective, and motivational functions. Chronic pain patients suffer from low dopamine production and delivery in this system. The volumes of structures constituting the mesolimbic system are known to be decreased in such patients. Studies on administration of dopaminergic drugs to control chronic pain, with a focus on increasing low dopamine levels in the mesolimbic system, show that it is effective in patients with Parkinson’s disease, restless legs syndrome, fibromyalgia, dry mouth syndrome, lumbar radicular pain, and chronic back pain. However, very few studies have confirmed these effects, and dopaminergic drugs are not commonly used to treat the various diseases causing chronic pain. Thus, further studies are required to determine the effectiveness of such treatment for chronic pain.

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