Behavioral response elicited by stimulation of the mesolimbic system after procaine and bicuculline injection into the pedunculopontine tegmental nucleus in rats

2013 ◽  
Vol 241 ◽  
pp. 161-172 ◽  
Author(s):  
Grażyna Jerzemowska ◽  
Karolina Plucińska ◽  
Irena Majkutewicz ◽  
Jolanta Orzeł-Gryglewska ◽  
Weronika Trojniar
Keyword(s):  
Behavioral Response ◽  
Pedunculopontine Tegmental Nucleus ◽  
Mesolimbic System ◽  
Tegmental Nucleus ◽  
Stimulation Of

scholarly journals Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus Renders Neuroprotection through the Suppression of Hippocampal Apoptosis: An Experimental Animal Study

2020 ◽  
Vol 10 (1) ◽  
pp. 25
Author(s):  
Chellappan Praveen Rajneesh ◽  
Tsung-Hsun Hsieh ◽  
Shih-Ching Chen ◽  
Chien-Hung Lai ◽  
Ling-Yu Yang ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Interleukin 6 ◽  
Pedunculopontine Tegmental Nucleus ◽  
Experimental Animals ◽  
Tegmental Nucleus ◽  
Hippocampal Apoptosis ◽  
Deep Brain ◽  
Stimulation Of

The core objective of this study was to determine the neuroprotective properties of deep brain stimulation of the pedunculopontine tegmental nucleus on the apoptosis of the hippocampus. The pedunculopontine tegmental nucleus is a prime target for Parkinson′s disease and is a crucial component in a feedback loop connected with the hippocampus. Deep brain stimulation was employed as a potential tool to evaluate the neuroprotective properties of hippocampal apoptosis. Deep brain stimulation was applied to the experimental animals for an hour. Henceforth, the activity of Caspase-3, myelin basic protein, Bcl-2, BAX level, lipid peroxidation, interleukin-6 levels, and brain-derived neurotrophic factor levels were evaluated at hours 1, 3 and 6 and compared with the sham group of animals. Herein, decreased levels of caspases activity and elevated levels of Bcl-2 expressions and inhibited BAX expressions were observed in experimental animals at the aforementioned time intervals. Furthermore, the ratio of Bcl-2/BAX was increased, and interleukin -6, lipid peroxidation levels were not affected by deep brain stimulation in the experimental animals. These affirmative results have explained the neuroprotection rendered by hippocampus apoptosis as a result of deep brain stimulation. Deep brain stimulation is widely used to manage neuro-motor disorders. Nevertheless, this novel study will be a revelation for a better understanding of neuromodulatory management and encourage further research with new dimensions in the field of neuroscience.

Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function

2011 ◽  
Vol 77 (6) ◽  
pp. 1135-1138 ◽  
Author(s):  
Hong-Bing Xiang ◽  
Cheng Liu ◽  
Qing-Qing Guo ◽  
Rong-Chun Li ◽  
Da-Wei Ye
Keyword(s):  
Renal Function ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Pedunculopontine Tegmental Nucleus ◽  
Tegmental Nucleus ◽  
Deep Brain ◽  
Stimulation Of
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