Prenatal programming of stress responsiveness and behaviours: Progress and perspectives

2019 ◽  
Vol 31 (3) ◽  
pp. e12674 ◽  
Author(s):  
Hirotaka Hamada ◽  
Stephen G. Matthews
Keyword(s):  
Prenatal Programming ◽  
Stress Responsiveness

Prenatal programming of hepatic lipid metabolism: Sex, hormones and lifelong health

2020 ◽  
Author(s):  
Katarzyna Siemienowicz ◽  
Panagiotis Filis ◽  
Chiara Talia ◽  
Jennifer Thomas ◽  
Paul Fowler ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Sex Hormones ◽  
Prenatal Programming ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

Sex differences in prenatal programming of hypertension by dexamethasone

2021 ◽  
pp. 153537022110032
Author(s):  
Issa Alhamoud ◽  
Susan K Legan ◽  
Jyothsna Gattineni ◽  
Michel Baum
Keyword(s):  
Blood Pressure ◽  
Plasma Renin ◽  
Female Offspring ◽  
Male Offspring ◽  
Thick Ascending Limb ◽  
Protein Abundance ◽  
Female Rat ◽  
Prenatal Programming ◽  
Transporter Protein ◽  
Renal Tubular

Prenatal dexamethasone has been shown to increase blood pressure in male offspring but the mechanism for the increase in blood pressure is unclear. The present study examined if prenatal programming by maternal injection of dexamethasone on days 15 and 16 of gestation affected the blood pressure comparably in female and male offspring. Our hypothesis was that males would be affected by prenatal dexamethasone to a greater extent than females and that either an increase in renal tubular transporter abundance or an increase in renin or aldosterone system would be associated with hypertension with prenatal programming. Prenatal dexamethasone increased blood pressure at two months and six months of age and resulted in proteinuria and albuminuria at six months in male but not female rat offspring. There was no effect of prenatal dexamethasone on blood pressure and proteinuria at one month in male and in female offspring. While prenatal dexamethasone increased male renal thick ascending limb sodium potassium two chloride cotransporter protein abundance at two months, prenatal dexamethasone on days 15 and 16 of gestation did not affect transporter abundance in males at other ages, nor did it affect proximal tubule sodium/hydrogen exchanger or distal convoluted tubule sodium chloride cotransporter protein abundance at any age. There was no difference in systemic renin or aldosterone in the prenatal dexamethasone group compared to same sex controls. In conclusion, male but not female offspring have an increase in blood pressure and urinary protein excretion with prenatal dexamethasone. The increase in blood pressure with prenatal programming was not associated with a consistent increase in renal tubular transporter protein abundance, nor plasma renin activity and serum aldosterone.

Stress-responsive properties of metallocenes in metallopolymers

2021 ◽  
Author(s):  
Ye Sha ◽  
Hao Zhang ◽  
Zhou Zhou ◽  
Zhenyang Luo
Keyword(s):  
Molecular Level ◽  
Building Blocks ◽  
Review Article ◽  
Stress Responsiveness

This review article combines the field of metallopolymers and stress-responsiveness on a molecular level, namely, metallocenes, as emerging stress-responsive building blocks for materials.

scholarly journals Keratins determine network stress responsiveness in reconstituted actin-keratin filament systems

Soft Matter ◽  
2021 ◽  
Author(s):  
Iman Elbalasy ◽  
Paul Mollenkopf ◽  
Cary Tutmarc ◽  
Harald Herrmann ◽  
Jörg Schnauß
Keyword(s):  
Cell Mechanics ◽  
Major Determinant ◽  
Stress Responsiveness ◽  
Keratin Filament

The cytoskeleton is a major determinant of cell mechanics, and alterations in the central mechanical aspects of cells are observed during many pathological situations. Therefore, it is essential to investigate...

FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

2011 ◽  
Vol 70 (10) ◽  
pp. 928-936 ◽  
Author(s):  
Chadi Touma ◽  
Nils Christian Gassen ◽  
Leonie Herrmann ◽  
Joyce Cheung-Flynn ◽  
Dominik R. Büll ◽  
...  
Keyword(s):  
Binding Protein ◽  
Coping Behavior ◽  
Fk506 Binding Protein ◽  
Stress Responsiveness ◽  
And Coping

scholarly journals Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens

2018 ◽  
Vol 103 (11) ◽  
pp. 3945-3953 ◽  
Author(s):  
Grace Huang ◽  
Sara Cherkerzian ◽  
Eric B Loucks ◽  
Stephen L Buka ◽  
Robert J Handa ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Sex Differences ◽  
Prenatal Programming
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