scholarly journals Previous Midlife Oestradiol Treatment Results in Long-Term Maintenance of Hippocampal Oestrogen Receptor α Levels in Ovariectomised Rats: Mechanisms and Implications for Memory

2016 ◽  
Vol 28 (10) ◽  
Author(s):  
K. L. Black ◽  
C. F. Witty ◽  
J. M. Daniel
Keyword(s):  
Oestrogen Receptor ◽  
Treatment Results ◽  
Oestradiol Treatment ◽  
Oestrogen Receptor Α ◽  
Term Maintenance ◽  
Ovariectomised Rats

scholarly journals Oestrogen receptor α agonist improved long-term ovariectomy-induced spatial cognition deficit in young rats

2013 ◽  
Vol 16 (5) ◽  
pp. 1071-1082 ◽  
Author(s):  
Na Qu ◽  
Lei Wang ◽  
Zan-Chao Liu ◽  
Qing Tian ◽  
Qi Zhang
Keyword(s):  
Cognitive Impairment ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Oestrogen Receptor ◽  
Synaptic Proteins ◽  
Ovariectomized Rats ◽  
Spatial Learning And Memory ◽  
Apoptosis Protein ◽  
Oestrogen Receptor Α

Abstract Ovariectomy is known as ‘surgical menopause’ with decreased levels of oestrogen in female rodents and its reported risks and adverse effects include cognitive impairment. In the brain, oestrogen exerts effects through its receptors, oestrogen receptor α (ERα) and β (ERβ). However, the role of ERα or ERβ in ovariectomy-induced cognitive impairment needs further investigation. Here, we observed that bilaterally ovariectomized 3-month-old rats showed obvious spatial learning and memory deficits in the Morris water maze with significant loss of neurons and synapses in the hippocampus. In addition to the rapid decline in serum oestradiol levels, the expression of ERα, but not ERβ, was decreased in the hippocampus starting 1 wk after ovariectomy. Prompt 4,4′,4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol (PPT) treatment (1 mg/kg.d), an agonist of ERα, improved the spatial learning and memory ability of ovariectomized rats and rescued ovariectomy-induced neuron loss by up-regulating the level of BCLxl, an important anti-apoptosis protein. Furthermore, PPT treatment also improved ovariectomy-induced hippocampal synapse loss and up-regulated the levels of synaptic proteins (synapsin I, NR2A and GluR1) and the activates of CaMK Πα, ERK and Akt. Thus, these results demonstrated that ERα plays an important role in neuroprotection and that prompt ERα rescue is effective to improve hippocampal-dependent cognition deficit after long-term ovariectomy.

Efficacious long-term maintenance therapy with pantoprazole (PAN) in patients with Zollinger-Ellison syndrome

2001 ◽  
Vol 120 (5) ◽  
pp. A613-A613
Author(s):  
P BORNMAN ◽  
K RADEBOLD ◽  
H DEBAERE ◽  
L VENTER ◽  
H HEINZE ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Zollinger Ellison Syndrome ◽  
Term Maintenance
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