Oestradiol-Induced Synapse Formation in the Female Hippocampus: Roles of Oestrogen Receptor Subtypes

2014 ◽  
Vol 26 (7) ◽  
pp. 439-447 ◽  
Author(s):  
L. Zhou ◽  
L. Fester ◽  
S. Haghshenas ◽  
X. de Vrese ◽  
R. von Hacht ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Synapse Formation ◽  
Receptor Subtypes

scholarly journals Molecular cues to the anti-implantation effect of nano-puerarin in rats

Reproduction ◽  
2016 ◽  
Vol 151 (6) ◽  
pp. 693-707 ◽  
Author(s):  
Ghungroo Saraswat ◽  
Rajdeep Guha ◽  
Kalyani Mondal ◽  
Piyali Saha ◽  
Sayani Banerjee ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Stromal Cell ◽  
Cell Activation ◽  
Drug Loading ◽  
Cyclin D3 ◽  
Receptor Subtypes ◽  
Decidual Cells ◽  
Dose Dependent

AbstractPuerarin, a selective oestrogen receptor modulator, intercepts implantation in rats, albeit at unacceptably higher doses. We developed poly lactic-co-glycolic acid-encapsulated nano-puerarin (PN) and mapped the molecular pathway underlying its anti-implantation effects. Smooth-surfaced and spherical PN having a mean diameter of ∼147nm was obtained with good yield, efficient encapsulation, and optimum drug loading. In culture, PN slowly and steadily released puerarin, which was readily taken up by the decidual cells. PN exerted a dose-dependent anti-implantation effect. As marked by attenuated expression of stromal cell desmin, alkaline phosphatase, IGFBP1, and decidual prolactin-related protein, the anti-implantation effect of PN seemed secondary to compromised decidualization. Usingin vivo(pregnant and pseudopregnant rats) andin vitro(endometrial stromal cell culture) treatment models, we document that PN enforced inhibition of uterine expression ofHbegfandHoxa10and their downstream signalling molecules, Cyclin D3 (CCND3)/CDK4. PN also efficiently ablated theIhh-Nr2f2-Bmp2signalling pathway and invited the loss of uterine potential for decidualization. There was a dose-dependent up-regulation of RHOA and its effector protein kinase, ROCK1, leading to the promotion of MLC phosphorylation and actin–myosin interaction. PN also down-regulated the stromal cell activation of ERK½ and expression of MMP9. These effects acting together stabilized the stroma and inhibited the stromal cell migration. Central to this array of events was the adversely altered endometrial expression of oestrogen receptor subtypes and repression of progesterone receptor that indulged endless proliferation of luminal epithelia and distorted the precisely choreographed stroma–epithelia crosstalk. Thus, PN dismantles the endometrial bed preparation and prevents implantation.

Author response for "Nectin‐2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula"

2020 ◽  
Author(s):  
Hajime Shiotani ◽  
Muneaki Miyata ◽  
Takeshi Kameyama ◽  
Kenji Mandai ◽  
Miwako Yamasaki ◽  
...  
Keyword(s):  
Synapse Formation ◽  
Cholinergic Neuron ◽  
Author Response ◽  
Medial Habenula

Prostaglandin E-type receptor subtypes and gastroduodenal bicarbonate secretion in rats

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S221-S226
Author(s):  
KOJI TAKEUCHI ◽  
KOJI YAGI ◽  
MOTOHIRO KITAMURA ◽  
MASAFUMI KUBOMI ◽  
KIM-IHITO TASHIMA
Keyword(s):  
Prostaglandin E ◽  
Receptor Subtypes ◽  
Bicarbonate Secretion ◽  
Type Receptor

Effect of H. pylori on the expression of TRAIL receptor subtypes and apoptosis in human gastric epithelial cells

2001 ◽  
Vol 120 (5) ◽  
pp. A81-A81
Author(s):  
J MARTIN ◽  
A POTTHOFF ◽  
M COMBERG ◽  
I SOBEKKLOCKE ◽  
S LEDIG ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Receptor Subtypes ◽  
Trail Receptor ◽  
Gastric Epithelial Cells ◽  
H Pylori
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