scholarly journals Increased acetylcholine and glutamate efflux in the prefrontal cortex following intranasal orexin-A (hypocretin-1)

2018 ◽  
Vol 145 (3) ◽  
pp. 232-244 ◽  
Author(s):  
Coleman B. Calva ◽  
Habiba Fayyaz ◽  
Jim R. Fadel
Keyword(s):  
Prefrontal Cortex ◽  
Orexin A ◽  
Glutamate Efflux ◽  
Hypocretin 1

Modulatory effects of hypocretin-1/orexin-A with glutamate and γ-aminobutyric acid on freshly isolated pyramidal neurons from the rat prefrontal cortex

2006 ◽  
Vol 399 (1-2) ◽  
pp. 101-105 ◽  
Author(s):  
Cheng-hui Song ◽  
Xiao-wei Chen ◽  
Jian-xia Xia ◽  
Zheng-ping Yu ◽  
Zhi-an Hu
Keyword(s):  
Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Aminobutyric Acid ◽  
Orexin A ◽  
Hypocretin 1

CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH)

2008 ◽  
Vol 145 (1-3) ◽  
pp. 60-64 ◽  
Author(s):  
Kenji Dohi ◽  
Beth Ripley ◽  
Nobuhiro Fujiki ◽  
Hirokazu Ohtaki ◽  
Takefumi Yamamoto ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Orexin A ◽  
Hypocretin 1

scholarly journals CSF Levels of Hypocretin-1 (Orexin-A) Peak during Early Infancy in Humans

SLEEP ◽  
2012 ◽  
Vol 35 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Adi Aran ◽  
Irina Shors ◽  
Ling Lin ◽  
Emmanuel Mignot ◽  
Michael S. Schimmel
Keyword(s):  
Early Infancy ◽  
Orexin A ◽  
Csf Levels ◽  
Hypocretin 1

Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures

Epilepsia ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1641-1644 ◽  
Author(s):  
Konrad Rejdak ◽  
Ewa Papuć ◽  
Paweł Grieb ◽  
Zbigniew Stelmasiak
Keyword(s):  
Cerebrospinal Fluid ◽  
Orexin A ◽  
Clonic Seizures ◽  
Hypocretin 1

scholarly journals Wen-Dan Decoction Improves Negative Emotions in Sleep-Deprived Rats by Regulating Orexin-A and Leptin Expression

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Fengzhi Wu ◽  
Yuehan Song ◽  
Feng Li ◽  
Xin He ◽  
Jie Ma ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Blood Serum ◽  
Leptin Receptor ◽  
Negative Emotions ◽  
Field Tests ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Orexin A ◽  
Therapeutic Mechanisms ◽  
Leptin Expression

Wen-Dan Decoction (WDD), a formula of traditional Chinese medicine, has been clinically used for treating insomnia for approximately 800 years. However, the therapeutic mechanisms of WDD remain unclear. Orexin-A plays a key role in the sleep-wake cycle, while leptin function is opposite to orexin-A. Thus, orexin-A and leptin may be important factors in sleep disorders. In this study, 48 rats were divided into control, model, WDD-treated, and diazepam-treated groups. The model of insomnia was produced by sleep deprivation (SD) for 14 days. The expressions of orexin-A, leptin, and their receptors in blood serum, prefrontal cortex, and hypothalamus were detected by enzyme-linked immunosorbent assay, immunohistochemistry, and real time PCR. Open field tests showed that SD increased both crossing movement (Cm) and rearing-movement (Rm) times. Orexin-A and leptin levels in blood serum increased after SD but decreased in brain compared to the control group. mRNA expressions of orexin receptor 1 and leptin receptor after SD were decreased in the prefrontal cortex but were increased in hypothalamus. WDD treatment normalized the behavior and upregulated orexin-A, leptin, orexin receptor 1 and leptin receptor in brain. The findings suggest that WDD treatment may regulate SD-induced negative emotions by regulating orexin-A and leptin expression.

Circadian variation of hypocretin-1 (orexin A) in restless legs syndrome

2009 ◽  
Vol 10 (2) ◽  
pp. 271
Author(s):  
Paul Christian Baier ◽  
Robert Göder ◽  
Manfred Hallschmid
Keyword(s):  
Restless Legs Syndrome ◽  
Circadian Variation ◽  
Orexin A ◽  
Restless Legs ◽  
Hypocretin 1

scholarly journals Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Paul Coleman ◽  
Luis De Lecea ◽  
Anthony Gotter ◽  
Jim Hagan ◽  
Rebecca Hills ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Proteolytic Cleavage ◽  
Clinical Use ◽  
Orexin A ◽  
Receptor Ligand ◽  
Orexin Receptors ◽  
Common Precursor ◽  
Peptide Modifications ◽  
Hypocretin 1

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [39]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [102]. Currently the only orexin receptor ligand in clinical use is suvorexant, which is used as a hypnotic. Orexin receptor crystal structures have been solved [124, 123].

scholarly journals Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators

2018 ◽  
Vol 145 (2) ◽  
pp. 111-124 ◽  
Author(s):  
Sarah N. Isherwood ◽  
Trevor W. Robbins ◽  
Jeffrey W. Dalley ◽  
Anton Pekcec
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Glutamate Efflux

scholarly journals Hypocretin-1 (Orexin-A) Levels in Human Lumbar CSF in Different Age Groups: Infants to Elderly Persons

SLEEP ◽  
2002 ◽  
Vol 25 (3) ◽  
pp. 337-339 ◽  
Author(s):  
Takashi Kanbayashi ◽  
Tamami Yano ◽  
Hideaki Ishiguro ◽  
Kentoh Kawanishi ◽  
Shigeru Chiba ◽  
...  
Keyword(s):  
Age Groups ◽  
Elderly Persons ◽  
Orexin A ◽  
Hypocretin 1
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