scholarly journals Hypocretin-1 (Orexin-A) Levels in Human Lumbar CSF in Different Age Groups: Infants to Elderly Persons

SLEEP ◽  
2002 ◽  
Vol 25 (3) ◽  
pp. 337-339 ◽  
Author(s):  
Takashi Kanbayashi ◽  
Tamami Yano ◽  
Hideaki Ishiguro ◽  
Kentoh Kawanishi ◽  
Shigeru Chiba ◽  
...  
Keyword(s):  
Age Groups ◽  
Elderly Persons ◽  
Orexin A ◽  
Hypocretin 1

CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH)

2008 ◽  
Vol 145 (1-3) ◽  
pp. 60-64 ◽  
Author(s):  
Kenji Dohi ◽  
Beth Ripley ◽  
Nobuhiro Fujiki ◽  
Hirokazu Ohtaki ◽  
Takefumi Yamamoto ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Orexin A ◽  
Hypocretin 1

scholarly journals CSF Levels of Hypocretin-1 (Orexin-A) Peak during Early Infancy in Humans

SLEEP ◽  
2012 ◽  
Vol 35 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Adi Aran ◽  
Irina Shors ◽  
Ling Lin ◽  
Emmanuel Mignot ◽  
Michael S. Schimmel
Keyword(s):  
Early Infancy ◽  
Orexin A ◽  
Csf Levels ◽  
Hypocretin 1

Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures

Epilepsia ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1641-1644 ◽  
Author(s):  
Konrad Rejdak ◽  
Ewa Papuć ◽  
Paweł Grieb ◽  
Zbigniew Stelmasiak
Keyword(s):  
Cerebrospinal Fluid ◽  
Orexin A ◽  
Clonic Seizures ◽  
Hypocretin 1

Circadian variation of hypocretin-1 (orexin A) in restless legs syndrome

2009 ◽  
Vol 10 (2) ◽  
pp. 271
Author(s):  
Paul Christian Baier ◽  
Robert Göder ◽  
Manfred Hallschmid
Keyword(s):  
Restless Legs Syndrome ◽  
Circadian Variation ◽  
Orexin A ◽  
Restless Legs ◽  
Hypocretin 1

scholarly journals Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Paul Coleman ◽  
Luis De Lecea ◽  
Anthony Gotter ◽  
Jim Hagan ◽  
Rebecca Hills ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Proteolytic Cleavage ◽  
Clinical Use ◽  
Orexin A ◽  
Receptor Ligand ◽  
Orexin Receptors ◽  
Common Precursor ◽  
Peptide Modifications ◽  
Hypocretin 1

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [39]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [102]. Currently the only orexin receptor ligand in clinical use is suvorexant, which is used as a hypnotic. Orexin receptor crystal structures have been solved [124, 123].

scholarly journals Decreased Cerebrospinal Fluid Orexin-A (Hypocretin-1) Concentrations in Patients after Generalized Convulsive Status Epilepticus

2020 ◽  
Vol 9 (10) ◽  
pp. 3354
Author(s):  
Mojdeh Samzadeh ◽  
Ewa Papuć ◽  
Marzena Furtak-Niczyporuk ◽  
Konrad Rejdak
Keyword(s):  
Cerebrospinal Fluid ◽  
Status Epilepticus ◽  
Neuronal Damage ◽  
Study Groups ◽  
Convulsive Status Epilepticus ◽  
Orexin A ◽  
Diagnostic Lumbar Puncture ◽  
Turn Over ◽  
Hypocretin 1

The effects of status epilepticus on the orexin/hypocretin system have yet to be investigated. The present study aimed to assay orexin-A/hypocretin-1 in the cerebrospinal fluid (CSF) of patients after generalized convulsive status epilepticus (GCSE). The study groups included 20 GCSE patients, 24 patients diagnosed with epilepsy but remaining in remission (ER), and 25 normal controls (CTR). Diagnostic lumbar puncture was performed in GCSE patients within 3–10 days of seizure cessation, as well as in the ER and to CTR subjects. Among all GCSE patients, the outcome was graded according to the modified Rankin Scale (mRS) at 1-month follow-up. Orexin-A levels were measured in unextracted CSF samples, using a commercial radioimmunoassay. There was a significant overall difference in median CSF orexin-A concentrations between GCSE, RE, and CTR patients (p < 0.001). The lowest concentrations were noted in the GCSE group compared to ER (p < 0.001) or CTR (p < 0.001). CSF orexin-A levels in GCSE patients inversely correlated with clinical outcome as assessed on the mRS at 1-month follow-up (r = −0.55; p = 0.1). In conclusion, CSF orexin-A levels may serve as a biomarker of increased turn-over of the peptide or post-SE neuronal damage, and implicates the orexin system in the pathogenesis of SE.

scholarly journals Brain weight in suicide

2000 ◽  
Vol 177 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Emad Salib ◽  
George Tadros
Keyword(s):  
Age Groups ◽  
Brain Weight ◽  
Postmortem Brain ◽  
Critical Examination ◽  
Elderly Persons ◽  
Post Mortem ◽  
Post Mortem Brain ◽  
Significant Difference ◽  
Self Harm ◽  
Set Up

BackgroundThere is little available literature on the effect of suicide methods on brain weight.AimsTo explore variations in postmortem brain weight in different methods of fatal self-harm (FSH) and in deaths from natural causes.MethodA review of a sample of coroners' records of elderly persons (60 and above). Verdicts of suicide, misadventure and open verdicts were classified as FSH. Post-mortem brain weight for 142 FSH victims and 150 victims of unexpected, sudden or unexplained death due to natural causes, and from various methods of FSH, were compared.ResultsBrain weight of victims of FSH was significantly higher than of those who died of natural causes (P<0.01); brain weights in both groups were within the normal range for this age group. There was no significant difference in brain weight between different methods of FSH (P>0.05).ConclusionsThe findings require critical examination and further research, to include data from younger age groups. A regional or national suicide neuropathological database could be set up if all victims of FSH underwent routine neurohistochemical post-mortem examination.

scholarly journals Narcolepsy Without Cataplexy: 2 Subtypes Based on CSF Hypocretin-1/Orexin-A Findings

SLEEP ◽  
2006 ◽  
Vol 29 (11) ◽  
pp. 1439-1443 ◽  
Author(s):  
Yasunori Oka ◽  
Yuichi Inoue ◽  
Takashi Kanbayashi ◽  
Kenji Kuroda ◽  
Masayuki Miyamoto ◽  
...  
Keyword(s):  
Orexin A ◽  
Hypocretin 1
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