scholarly journals Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats

2015 ◽  
Vol 135 (2) ◽  
pp. 357-367 ◽  
Author(s):  
Hui Shu ◽  
Guo-qing Zheng ◽  
Xiaona Wang ◽  
Yanyun Sun ◽  
Yushan Liu ◽  
...  
Keyword(s):  
Working Memory ◽  
Matrix Metalloproteinase ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus

scholarly journals Dorsal Hippocampus Not Always Necessary in a Radial Arm Maze Delayed Win-shift Task

2018 ◽  
Author(s):  
Dylan Layfield ◽  
Nathan Sidell ◽  
Afnan Abdullahi ◽  
Ehren L. Newman
Keyword(s):  
Working Memory ◽  
Test Performance ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus ◽  
Radial Arm Maze ◽  
Spatial Coding ◽  
Shift Task ◽  
Neural Underpinnings ◽  
Retention Intervals ◽  
Phosphate Buffered Saline

AbstractSpatial working memory is important for foraging and navigating the environment. However, its neural underpinnings remain poorly understood. The hippocampus, known for its spatial coding and involvement in spatial memory, is widely understood to be necessary for spatial working memory when retention intervals increase beyond seconds into minutes. Here, we describe new evidence that the dorsal hippocampus is not always necessary for spatial working memory for retention intervals of 8 minutes. Rats were trained to perform a delayed spatial win shift radial arm maze task (DSWS) with an 8-minute delay between study and test phases. We then tested whether bilateral inactivation of the dorsal hippocampus between the study and test phases impaired behavioral performance at test. Inactivation was achieved through a bilateral infusion of lidocaine. Performance following lidocaine was compared to control trials, in which, sterile phosphate buffered saline (PBS) was infused. Test performance did not differ between the lidocaine and PBS conditions, remaining high in each. To explore the possibility that this insensitivity to inactivation was a result of overtraining, a second cohort of animals received substantially less training prior to the infusions. In this second cohort, lidocaine infusions did significantly impair task performance. These data indicate that successful performance of a spatial win-shift task on the 8-arm maze need not always be hippocampally dependent.

scholarly journals Striatal Versus Hippocampal Representations During Win-Stay Maze Performance

2009 ◽  
Vol 101 (3) ◽  
pp. 1575-1587 ◽  
Author(s):  
Joshua D. Berke ◽  
Jason T. Breck ◽  
Howard Eichenbaum
Keyword(s):  
Working Memory ◽  
Neural Coding ◽  
Hippocampal Neurons ◽  
Spatial Information ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus ◽  
Place Cell ◽  
Projection Neurons ◽  
Behavioral Strategies ◽  
Cell Type

The striatum and hippocampus are widely held to be components of distinct memory systems that can guide competing behavioral strategies. However, some electrophysiological studies have suggested that neurons in both structures encode spatial information and may therefore make similar contributions to behavior. In rats well trained to perform a win-stay radial maze task, we recorded simultaneously from dorsal hippocampus and from multiple striatal subregions, including both lateral areas implicated in motor responses to cues and medial areas that work cooperatively with hippocampus in cognitive operations. In each brain region, movement through the maze was accompanied by the continuous sequential activation of sets of projection neurons. Hippocampal neurons overwhelmingly were active at a single spatial location (place cells). Striatal projection neurons were active at discrete points within the progression of every trial—especially during choices or following reward delivery—regardless of spatial position. Place-cell–type firing was not observed even for medial striatal cells entrained to the hippocampal theta rhythm. We also examined neural coding in earlier training sessions, when rats made use of spatial working memory to guide choices, and again found that striatal cells did not show place-cell–type firing. Prospective or retrospective encoding of trajectory was not observed in either hippocampus or striatum, at either training stage. Our results indicate that, at least in this task, dorsal hippocampus uses a spatial foundation for information processing that is not substantially modulated by spatial working memory demands. By contrast, striatal cells do not use such a spatial foundation, even in medial subregions that cooperate with hippocampus in the selection of spatial strategies. The progressive dominance of a striatum-dependent strategy does not appear to be accompanied by large changes in striatal or hippocampal single-cell representations, suggesting that the conflict between strategies may be resolved elsewhere.

scholarly journals NMDAr BLOCKING BY MK801 ALTERS HIPPOCAMPAL AND PREFRONTAL CORTEX OSCILLATIONS AND IMPAIRS SPATIAL WORKING MEMORY IN MICE.

2021 ◽  
Author(s):  
Pablo Abad-Perez ◽  
Luis M Martinez ◽  
Victor Borrell ◽  
Roger Redondo ◽  
Jorge R Brotons-Mas
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus ◽  
Gamma Oscillations ◽  
Oscillatory Activity ◽  
Y Maze ◽  
Spontaneous Exploration ◽  
New Treatments ◽  
And Behavior

Abnormal NMDAr function has been linked to rhythmopathies, psychosis, and cognitive dysfunction in schizophrenia. Here, we investigate the role of NMDAr hypofunction in pathological oscillations and behavior. We implanted mice with tetrodes in the dorsal hippocampus and medial prefrontal cortex (mPFC) and administered them with the NMDAr antagonist MK801, recording oscillations during spontaneous exploration in an open field and in the y-maze spatial working memory test. Our results show that NMDAr blockade increased locomotor activity and impaired spatial working memory. The administration of MK801 disrupted the correlation between oscillations and speed of movement, crucial for internal representations of distance. In the hippocampus, MK801 impaired gamma oscillations and theta/gamma coupling, while in the mPFC, it increased the power of theta, gamma, and generated high-frequency oscillations (HFO 155-185 Hz). Spatial working memory tests in the y-maze revealed that theta/gamma coupling was consistently higher in correct trials. Theta/gamma co-modulation mediated by NMDAr function might be key to explain various of schizophrenia's cognitive symptoms. Further investigating NMDAr hypofunction's role in the emergence of aberrant oscillatory activity will improve our understanding of schizophrenia and inspire new treatments of psychiatric disorders.

Working Memory and Number Sense as Predictors of Mathematical (Dis-)Ability

2015 ◽  
Vol 223 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Evelyn H. Kroesbergen ◽  
Marloes van Dijk
Keyword(s):  
Working Memory ◽  
Learning Disabilities ◽  
Spatial Working Memory ◽  
Number Sense ◽  
Mathematical Learning ◽  
Visual Spatial ◽  
Mathematical Learning Disabilities ◽  
Visual Spatial Working Memory ◽  
And Mathematics

Recent research has pointed to two possible causes of mathematical (dis-)ability: working memory and number sense, although only few studies have compared the relations between working memory and mathematics and between number sense and mathematics. In this study, both constructs were studied in relation to mathematics in general, and to mathematical learning disabilities (MLD) in particular. The sample consisted of 154 children aged between 6 and 10 years, including 26 children with MLD. Children performing low on either number sense or visual-spatial working memory scored lower on math tests than children without such a weakness. Children with a double weakness scored the lowest. These results confirm the important role of both visual-spatial working memory and number sense in mathematical development.

Glucose Effects on Spatial Working Memory are Dose and Delay Specific

1999 ◽  
Author(s):  
Jarod N. Wright ◽  
Clint D. Walker ◽  
Russell E. Morgan
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Glucose Effects

Spatial Working Memory Deficit in Autism

2003 ◽  
Author(s):  
Shelly D. Steele ◽  
Nancy J. Minshew ◽  
Bea Luna ◽  
John A. Sweeney
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Deficit
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