scholarly journals Neuregulin 1 up-regulates the expression of nicotinic acetylcholine receptors through the ErbB2/ErbB3-PI3K-MAPK signaling cascade in adult autonomic ganglion neurons

2012 ◽  
Vol 124 (4) ◽  
pp. 502-513 ◽  
Author(s):  
Han-Gyu Kim ◽  
Choong-Ku Lee ◽  
Sung-Min Cho ◽  
Kum Whang ◽  
Byong-Ho Cha ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Mapk Signaling ◽  
Signaling Cascade ◽  
Autonomic Ganglion ◽  
Nicotinic Acetylcholine ◽  
Neuregulin 1 ◽  
Ganglion Neurons

Localization of Nicotinic Acetylcholine Receptors on Somatic Spines of Chick Ciliary Ganglion Neurons

1999 ◽  
Vol 5 (S2) ◽  
pp. 1028-1029
Author(s):  
R. Shoop ◽  
M. Martone ◽  
N. Yamada ◽  
M. Ellisman ◽  
D. Berg
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Transmitter Release ◽  
Acetylcholine Receptors ◽  
Ciliary Ganglion ◽  
Nicotinic Acetylcholine ◽  
Selective Ligand ◽  
Somatic Spines ◽  
Ciliary Ganglion Neurons ◽  
Ganglion Neurons ◽  
Immunohistochemical Studies

Nicotinic acetylcholine receptors (nAChRs) are pentameric membrane proteins that function as cation selective, ligand-gated ion channels and are widely distributed throughout the vertebrate nervous system. One of the most abundant nAChRs is a species that contains the α7 gene product (α7-AChRs), binds the snake venom oc-bungarotoxin, and rapidly desensitizes. These receptors have been shown to function at presynaptic sites to modulate transmitter release, as well as on postsynaptic cells where they mediate transmission. Interestingly, these receptors have an exceptionally high relative permeability to calcium.In the chick ciliary ganglion, the α 7-AChRs play a prominent role, by generating large synaptic currents, but the receptors appear to be excluded from postysnaptic densities on the cell. Immunohistochemical studies have shown that the receptors form large clusters on the surface of the ciliary ganglion neurons. We have recently shown that the α 7-containing receptors are concentrated on mats of somatic spines in close proximity to putative sites of presynaptic transmitter release.

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