scholarly journals Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats

2012 ◽  
Vol 124 (1) ◽  
pp. 133-146 ◽  
Author(s):  
Arabinda Das ◽  
M. Kelly Guyton ◽  
Amena Smith ◽  
Gerald Wallace ◽  
Misty L. McDowell ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Nerve Damage ◽  
Calpain Inhibitor ◽  
Optic Nerve Damage ◽  
Acute Optic Neuritis

On the Protective Effect of Lycium Barbarum Polysaccharide (LBP) on Optic Nerve Tissue and Retinal Ganglion Cells

2020 ◽  
Vol 10 (4) ◽  
pp. 443-448
Author(s):  
Shuzhen Wang ◽  
Zelin Xu ◽  
Yuanyuan Zhao ◽  
Chao Liu
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Protective Effect ◽  
Intrathecal Injection ◽  
Nerve Damage ◽  
Nerve Tissue ◽  
Blue Staining ◽  
Lycium Barbarum ◽  
Optic Nerve Damage ◽  
Lycium Barbarum Polysaccharide

Background: The present paper established a model of optic neuritis injury by intrathecal injection of lipopolysaccharide (LPS) into the optic nerve, then explored the protective effect of Lycium Barbarum Polysaccharide (LBP) on optic nerve tissue and RGCs after injury. Material and methods: LPS was microinjected into the optic nerve of SD rats to induce optic neuritis. The histopathological variations of HE staining were observed in each group. The expressions of ED1/CD68 and GFAP were determined by immunofluorescence. The optic nerve repairment was evaluated by lux solid blue staining. TUNEL detects retinal cell apoptosis. Western blot was used to detect differences in expressions of related proteins. Results: LBP can alleviate the degree of optic nerve damage in rats with optic neuritis injury, inhibit the increase of LPS-induced macrophages and astrocytes in the optic nerve and retina, mitigate LPS-induced retinal RGC damage, inhibit LPS-induced expressions of proinflammatory cytokines TNF-α and IL-6, COX2 and iNOS in the optic nerve injury model of optic neuritis in rats, as well as inhibit the activation of STAT1, STAT3 and NF-κB pathways. Conclusion: LBP can ameliorate optic nerve damage, and the mechanism may be realized through inhibiting NF- B and STAT signaling pathways.

scholarly journals Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

2012 ◽  
Vol 9 (1) ◽  
Author(s):  
Roberta Brambilla ◽  
Galina Dvoriantchikova ◽  
David Barakat ◽  
Dmitry Ivanov ◽  
John R Bethea ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Nerve Damage ◽  
Retinal Ganglion ◽  
Optic Nerve Damage

Critical Role of Monocyte Recruitment in Optic Nerve Damage Induced by Experimental Optic Neuritis

2019 ◽  
Vol 56 (11) ◽  
pp. 7458-7472 ◽  
Author(s):  
Marcos L. Aranda ◽  
Diego Guerrieri ◽  
Gonzalo Piñero ◽  
María F. González Fleitas ◽  
Florencia Altschuler ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Critical Role ◽  
Nerve Damage ◽  
Optic Nerve Damage ◽  
Monocyte Recruitment

Optic Nerve Damage in Alzheimer's Disease

Ophthalmology ◽  
1990 ◽  
Vol 97 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Alfredo A. Sadun ◽  
Carl J. Bassi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Optic Nerve ◽  
Nerve Damage ◽  
Optic Nerve Damage

scholarly journals Taurine protects against retinal and optic nerve damage induced by endothelin-1 in rats via antioxidant effects

2018 ◽  
Vol 13 (11) ◽  
pp. 2014 ◽  
Author(s):  
Renu Agarwal ◽  
NatashaNajwa Nor Arfuzir ◽  
Igor Iezhitsa ◽  
Puneet Agarwal ◽  
Sabrilhakim Sidek ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Damage ◽  
Endothelin 1 ◽  
Optic Nerve Damage ◽  
Antioxidant Effects

scholarly journals A Case of Locally Invasive Fungal Sinusitis Resulting in Optic Nerve Damage

2012 ◽  
Vol 23 (2) ◽  
pp. 270-273
Author(s):  
Jung-Hoon Lee ◽  
Chan-Hwi Park ◽  
Kyu-Sup Cho ◽  
Hwan-Jung Roh
Keyword(s):  
Optic Nerve ◽  
Nerve Damage ◽  
Fungal Sinusitis ◽  
Optic Nerve Damage ◽  
Invasive Fungal Sinusitis

Comparisons of Methods To Detect Glaucomatous Optic Nerve Damage

Ophthalmology ◽  
1993 ◽  
Vol 100 (10) ◽  
pp. 1498-1503 ◽  
Author(s):  
Daniel J. O'Connor ◽  
Thierry Zeyen ◽  
Joseph Caprioli
Keyword(s):  
Optic Nerve ◽  
Nerve Damage ◽  
Optic Nerve Damage

Letter to the Editor. Low ICP and normal tension glaucoma: optic nerve damage due to barotraumatic factors, failure of CSF dynamics, or both?

2018 ◽  
Vol 129 (4) ◽  
pp. 1100-1103
Author(s):  
Peter Wostyn ◽  
Veva De Groot ◽  
Debby Van Dam ◽  
Kurt Audenaert ◽  
Peter Paul De Deyn ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Normal Tension Glaucoma ◽  
Nerve Damage ◽  
Csf Dynamics ◽  
Optic Nerve Damage ◽  
Letter To The Editor
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