scholarly journals Quantitative evaluation of boron neutron capture therapy (BNCT) drugs for boron delivery and retention at subcellular-scale resolution in human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS)

2014 ◽  
Vol 254 (3) ◽  
pp. 146-156 ◽  
Author(s):  
S. CHANDRA ◽  
T. AHMAD ◽  
R. F. BARTH ◽  
G. W. KABALKA
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Evaluation ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Secondary Ion Mass Spectrometry ◽  
Neutron Capture Therapy ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Boron Neutron Capture ◽  
Secondary Ion

scholarly journals Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS

The Analyst ◽  
2019 ◽  
Vol 144 (21) ◽  
pp. 6214-6224
Author(s):  
Samar Aldossari ◽  
Greg McMahon ◽  
Nicholas P. Lockyer ◽  
Katie L. Moore
Keyword(s):  
Neutron Capture ◽  
Secondary Ion Mass Spectrometry ◽  
Drug Distribution ◽  
High Sensitivity ◽  
Biological Tissues ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Medium Mass ◽  
Distribution Studies ◽  
Secondary Ion

The ability of secondary ion mass spectrometry (SIMS) to provide high sensitivity imaging of elements and small-medium mass molecules in biological tissues and cells, makes it a very powerful tool for drug distribution studies.

scholarly journals A Study of The Assessment for Boron Neutron Capture Therapy Agent

2017 ◽  
Vol 2 (1) ◽  
pp. 9
Author(s):  
Isman Mulyadi Triatmoko ◽  
Sutjipto Sutjipto
Keyword(s):  
Cytotoxic Activity ◽  
Neutron Irradiation ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Glioblastoma Cells ◽  
Morphological Alterations ◽  
Boron Neutron Capture ◽  
Icp Ms ◽  
Biological Effectiveness

A study of the assessment criteria covers the synthesis and characterization of agent and test their biological effectiveness as boron neutron capture therapy (BNCT) agents in cancer treatment. The cellular uptake of this agent into the glioblastoma cells was assessed by boron analysis (ICP-MS) and by fluorescence imaging (confocal microscopy). The agent enters the glioblastoma cells exhibiting a similar profile, i.e., preferential accumulation in the cytoskeleton and membranes and a low cytotoxic activity (IC<sub>50</sub> values higher than 200 μM). The cytotoxic activity and cellular morphological alterations after neutron irradiation in the Research Reactor (&gt;10<sup>7</sup> neutrons cm<sup>−2</sup> s<sup>−1</sup>) were assessed by the MTT assay and by electron microscopy (TEM). Post neutron irradiation revealed that BNCT has a higher cytotoxic effect on the glioblastoma cells. Results provide a strong rationale for considering one of these compounds as a lead candidate for a new BNCT agent.

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