Psychiatric diagnostic screening of social maladaptive behaviour in children with mild intellectual disability: differentiating disordered attachment and pervasive developmental disorder behaviour

2013 ◽  
Vol 59 (2) ◽  
pp. 138-149 ◽  
Author(s):  
H. P. Giltaij ◽  
P. S. Sterkenburg ◽  
C. Schuengel
Keyword(s):  
Intellectual Disability ◽  
Pervasive Developmental Disorder ◽  
Developmental Disorder ◽  
Mild Intellectual Disability ◽  
Diagnostic Screening ◽  
Disorder Behaviour ◽  
Maladaptive Behaviour

scholarly journals Intellectual disability co-occurring with schizophrenia and other psychiatric illness: population-based study

2008 ◽  
Vol 193 (5) ◽  
pp. 364-372 ◽  
Author(s):  
Vera A. Morgan ◽  
Helen Leonard ◽  
Jenny Bourke ◽  
Assen Jablensky
Keyword(s):  
Intellectual Disability ◽  
Pervasive Developmental Disorder ◽  
Dual Diagnosis ◽  
Psychiatric Illness ◽  
Developmental Disorder ◽  
Clinical Manifestations ◽  
Unipolar Depression ◽  
Population Based ◽  
Disability Services ◽  
Common Pathogenesis

BackgroundThe epidemiology of intellectual disability co-occurring with schizophrenia and other psychiatric illness is poorly understood. The separation of mental health from intellectual disability services has led to a serious underestimation of the prevalence of dual diagnosis, with clinicians ill-equipped to treat affected individuals.AimsTo estimate the prevalence of dual diagnosis and describe its clinical profile.MethodThe Western Australian population-based psychiatric and intellectual disability registers were cross-linked (totaln=245 749).ResultsOverall, 31.7% of people with an intellectual disability had a psychiatric disorder; 1.8% of people with a psychiatric illness had an intellectual disability. Schizophrenia, but not bipolar disorder and unipolar depression, was greatly overrepresented among individuals with a dual diagnosis: depending on birth cohort, 3.7–5.2% of those with intellectual disability had co-occurring schizophrenia. Pervasive developmental disorder was identified through the Intellectual Disability Register and is therefore limited to individuals with intellectual impairment. None the less, pervasive developmental disorder was more common among people with a dual diagnosis than among individuals with intellectual disability alone. Down syndrome was much less prevalent among individuals with a dual diagnosis despite being the most predominant cause of intellectual disability. Individuals with a dual diagnosis had higher mortality rates and were more disabled than those with psychiatric illness alone.ConclusionsThe facility to combine records across administrative jurisdictions has enhanced our understanding of the epidemiology of dual diagnosis, its clinical manifestations and aetiological implications. In particular, our results are suggestive of a common pathogenesis in intellectual disability co-occurring with schizophrenia.

scholarly journals Instrument to screen cases of pervasive developmental disorder: a preliminary indication of validity

2009 ◽  
Vol 31 (1) ◽  
pp. 30-33 ◽  
Author(s):  
Fábio Pinato Sato ◽  
Cristiane Silvestre Paula ◽  
Rosane Lowenthal ◽  
Eduardo Yoshio Nakano ◽  
Décio Brunoni ◽  
...  
Keyword(s):  
Pervasive Developmental Disorder ◽  
Developmental Disorder ◽  
Internal Validity ◽  
Measurement Properties ◽  
Diagnostic Screening ◽  
Final Version ◽  
Preliminary Validation ◽  
Psychometric Measures ◽  
Brazilian Culture ◽  
Self Administered Questionnaire

OBJECTIVE: To translate into Portuguese, back-translate, culturally adapt and validate a screening instrument for pervasive developmental disorder, the Autism Screening Questionnaire, for use in Brazil. METHOD: A sample of 120 patients was selected based on three groups of 40: patients with a clinical diagnosis of pervasive developmental disorder, Down syndrome, or other psychiatric disorders. The self-administered questionnaire was applied to the patients' legal guardians. Psychometric measures of the final version of the translated questionnaire were tested. RESULTS: The score of 15 had sensitivity of 92.5% and specificity of 95.5% as a cut-off point for the diagnosis of pervasive developmental disorder. Internal validity for a total of 40 questions was 0.895 for alpha and 0.896 for KR-20, ranging from 0.6 to 0.8 for both coefficients. Test and retest reliability values showed strong agreement for most questions. CONCLUSIONS: The final version of this instrument, translated into Portuguese and adapted to the Brazilian culture, had satisfactory measurement properties, suggesting preliminary validation proprieties. It was an easy-to-apply, useful tool for the diagnostic screening of individuals with pervasive developmental disorder.

RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children

The Lancet ◽  
1998 ◽  
Vol 351 (9103) ◽  
pp. 637-641 ◽  
Author(s):  
AJ Wakefield ◽  
SH Murch ◽  
A Anthony ◽  
J Linnell ◽  
DM Casson ◽  
...  
Keyword(s):  
Pervasive Developmental Disorder ◽  
Developmental Disorder ◽  
Nodular Hyperplasia ◽  
Lymphoid Nodular Hyperplasia

Subtypes of Pervasive Developmental Disorder: Clinical Characteristics

1999 ◽  
Vol 5 (1) ◽  
pp. 1-23 ◽  
Author(s):  
Deborah Fein ◽  
Michael Stevens ◽  
Michelle Dunn ◽  
Lynn Waterhouse ◽  
Doris Allen ◽  
...  
Keyword(s):  
Pervasive Developmental Disorder ◽  
Clinical Characteristics ◽  
Developmental Disorder

scholarly journals Comprehensive study of 28 individuals with SIN3A-related disorder underscoring the associated mild cognitive and distinctive facial phenotype

2021 ◽  
Author(s):  
Meena Balasubramanian ◽  
Alexander J. M. Dingemans ◽  
Shadi Albaba ◽  
Ruth Richardson ◽  
Thabo M. Yates ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Protein Function ◽  
Autism Spectrum ◽  
Loss Of Function ◽  
Mild Intellectual Disability ◽  
Related Disorder ◽  
Feeding Difficulties ◽  
Facial Phenotype ◽  
Novel Variants ◽  
Common Behaviour

AbstractWitteveen-Kolk syndrome (OMIM 613406) is a recently defined neurodevelopmental syndrome caused by heterozygous loss-of-function variants in SIN3A. We define the clinical and neurodevelopmental phenotypes related to SIN3A-haploinsufficiency in 28 unreported patients. Patients with SIN3A variants adversely affecting protein function have mild intellectual disability, growth and feeding difficulties. Involvement of a multidisciplinary team including a geneticist, paediatrician and neurologist should be considered in managing these patients. Patients described here were identified through a combination of clinical evaluation and gene matching strategies (GeneMatcher and Decipher). All patients consented to participate in this study. Mean age of this cohort was 8.2 years (17 males, 11 females). Out of 16 patients ≥ 8 years old assessed, eight (50%) had mild intellectual disability (ID), four had moderate ID (22%), and one had severe ID (6%). Four (25%) did not have any cognitive impairment. Other neurological symptoms such as seizures (4/28) and hypotonia (12/28) were common. Behaviour problems were reported in a minority. In patients ≥2 years, three were diagnosed with Autism Spectrum Disorder (ASD) and four with Attention Deficit Hyperactivity Disorder (ADHD). We report 27 novel variants and one previously reported variant. 24 were truncating variants; three were missense variants and one large in-frame gain including exons 10–12.

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