Impact of liver‐stiffness measurement on hepatocellular carcinoma development in chronic hepatitis C patients treated with direct‐acting antivirals: A systematic review and time‐to‐event meta‐analysis

2020 ◽  
Author(s):  
Myung‐Won You ◽  
Kyung Won Kim ◽  
Jae‐Jun Shim ◽  
Junhee Pyo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Meta Analysis ◽  
Liver Stiffness ◽  
Direct Acting Antivirals ◽  
Time To Event ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement ◽  
Direct Acting ◽  
Chronic Hepatitis C Patients

scholarly journals Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct-acting antivirals

JGH Open ◽  
2017 ◽  
Vol 1 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Yoshihiko Tachi ◽  
Takanori Hirai ◽  
Yuko Kojima ◽  
Yoji Ishizu ◽  
Takashi Honda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Stiffness ◽  
Direct Acting Antivirals ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement ◽  
Direct Acting

scholarly journals Hepatocellular Carcinoma Recurrence after Hepatitis C Virus Therapy with Direct-Acting Antivirals. A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (8) ◽  
pp. 1694
Author(s):  
Leonardo Frazzoni ◽  
Usama Sikandar ◽  
Flavio Metelli ◽  
Sinan Sadalla ◽  
Giuseppe Mazzella ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Meta Analysis ◽  
Random Effect ◽  
Complete Response ◽  
Direct Acting Antivirals ◽  
Direct Acting ◽  
Hcc Recurrence

Background: Hepatocellular carcinoma (HCC) is a major cause of morbidity and mortality among patients with cirrhosis. The risk of HCC recurrence after a complete response among patients treated with direct-acting antivirals (DAAs) has not been fully elucidated yet. Aim: To assess the risk of HCC recurrence after DAA therapy for hepatitis C virus (HCV). Methods: A systematic review across PubMed, Scopus and Scholar up to November 2020, including full-text studies that assessed the pattern of HCC recurrence after DAA therapy for HCV. Random-effect meta-analysis and univariable metaregression were applied to obtain pooled estimates for proportions and relative risk (RR) and variables influential for the outcome, respectively. Results: Thirty-one studies with 2957 patients were included. Overall, 30% (CI, 26–34%) of the patients with a history of HCC experienced HCC recurrence after DAA therapy, at mean time intervals ranging from 4 to 21 months. This result increased when going from European studies (23%, CI, 17–28%) to US studies (34%, CI, 30–38%), to Egyptian studies (37%, CI, 27–47%), and to Asian studies (33%, CI, 27–40%). Sixty-eight percent (CI, 45–91%) of recurrent HCCs developed within 6 months of follow-up since DAA treatment, among the eight studies providing stratified data. Among the studies providing head-to-head comparisons, the HCC recurrence risk was significantly lower after DAA therapy than IFN (RR, 0.64; CI, 0.51–0.81), and after DAA therapy than no intervention (RR, 0.68; CI, 0.49–0.94). Conclusions: The recurrence of HCC after DAA is not negligible, being higher soon after the end of treatment and among non-European countries. DAA therapy seems to reduce the risk of HCC recurrence compared to an IFN regimen and no intervention.

Impact of Hepatitis C Virus (HCV) Eradication Following Direct Acting Antivirals Treatment (DAA) on Liver Stiffness Measurement (LSM)

2017 ◽  
Vol 152 (5) ◽  
pp. S1105-S1106
Author(s):  
Mohammed Tag-Adeen S. Khalil ◽  
Ahlam M. Sapra ◽  
Yuko Akazawa ◽  
Ken Ohnita ◽  
Kazuhiko Nakao
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Stiffness ◽  
Direct Acting Antivirals ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement ◽  
Direct Acting

Role of Liver Stiffness Measurement in Predicting HCC Occurrence in Direct-Acting Antivirals Setting: A Real-Life Experience

2019 ◽  
Vol 64 (10) ◽  
pp. 3013-3019 ◽  
Author(s):  
Luca Rinaldi ◽  
Maria Guarino ◽  
Alessandro Perrella ◽  
Pia Clara Pafundi ◽  
Giovanna Valente ◽  
...  
Keyword(s):  
Life Experience ◽  
Liver Stiffness ◽  
Real Life ◽  
Direct Acting Antivirals ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement ◽  
Direct Acting
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