Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

2018 ◽  
Vol 34 (4) ◽  
pp. 720-727 ◽  
Author(s):  
Keng‐Liang Wu ◽  
Yi‐Chun Chiu ◽  
Chih‐Chien Yao ◽  
Cheng‐En Tsai ◽  
Ming‐Luen Hu ◽  
...  
2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Chang-Chun Hsiao ◽  
Wei-Han Huang ◽  
Kuang-Hung Cheng ◽  
Chien-Te Lee

Background. Diabetic nephropathy is the most common cause of end-stage renal disease. Traditional therapy for diabetic nephropathy has focused on supportive treatment, and there is no significant effective therapy. We investigated the effect of low-energy extracorporeal shock wave therapy on a diabetic nephropathy rat model. Methods. Streptozotocin-induced diabetic nephropathy rats were treated with six sessions of low-energy extracorporeal shock wave therapy (weekly for six consecutive weeks) or left untreated. We assessed urinary creatinine and albumin, glomerular volume, renal fibrosis, podocyte number, renal inflammation, oxidative stress, and tissue repair markers (SDF-1 and VEGF) six weeks after the completion of treatment. Results. The six-week low-energy extracorporeal shock wave therapy regimen decreased urinary albumin excretion as well as reduced glomerular hypertrophy and renal fibrosis in the rat model of diabetic nephropathy. Moreover, low-energy extracorporeal shock wave therapy increased podocyte number in diabetic nephropathy rats. This was likely primarily attributed to the fact that low-energy extracorporeal shock wave therapy reduced renal inflammation and oxidative stress as well as increased tissue repair potency and cell proliferation. Conclusions. Low-energy extracorporeal shock wave therapy preserved kidney function in diabetic nephropathy. Low-energy extracorporeal shock wave therapy may serve as a novel noninvasive and effective treatment of diabetic nephropathy.


2020 ◽  
Vol 127 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Ahmed Elkashef ◽  
Nashwa Barakat ◽  
Sherry M. Khater ◽  
Amira Awadalla ◽  
Fathallah Belal ◽  
...  

2018 ◽  
Vol 15 (2) ◽  
pp. S46
Author(s):  
W.J. Bae ◽  
G.Q. Zhu ◽  
S.W. Choi ◽  
H.C. Jeong ◽  
F. Bashraheel ◽  
...  
Keyword(s):  

2017 ◽  
Vol 6 (S3) ◽  
pp. AB098-AB098
Author(s):  
Woong Jin Bae ◽  
Guan Qun Zhu ◽  
Sae Woong Choi ◽  
Hyun Cheol Jeong ◽  
Fahad Bashraheel ◽  
...  
Keyword(s):  

2019 ◽  
Vol 156 (6) ◽  
pp. S-1051
Author(s):  
Naoto Ujiie ◽  
Toru Nakano ◽  
Masato Yamada ◽  
Chiaki Sato ◽  
Chikashi Nakanishi ◽  
...  

2016 ◽  
Vol 13 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Huixi Li ◽  
Melanie P. Matheu ◽  
Fionna Sun ◽  
Lin Wang ◽  
Melissa T. Sanford ◽  
...  

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